Phase 2 N=117 Asacol Acute Diverticulitis(DIVA)Study
Diverticulitis
Primary: Global Symptom Score (GSS) at Week 12, Primary Efficacy Population — 7.3; 4.4; 5.9 Scores on a Scale — p=0.3781
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=107 Recurrence Following Nonoperative Management of 1st Episode of Hinchey II Diverticulitis
Diverticulitis
Primary: Primary Study Endpoint — 26; 2 Participants
N/A N=66 Laparoscopic Peritoneal Lavage vs Laparoscopic Sigmoidectomy in Perforated Acute Diverticulitis: a Multicenter Prospective Observational Study (STELLA Study)
Acute Diverticulitis
Primary: Short-term Morbidity — 8; 1 Participants
Phase 3 N=592 Prevention of Recurrence of Diverticulitis
Diverticulitis
Primary: Percent of Subjects Without Recurrence of Diverticulitis — 62.8; 59.2; 69.1; 67.6 percentage of subjects — p=0.778
Phase 3 N=590 Prevention of Recurrence of Diverticulitis
Diverticulitis
Primary: Percent of Subjects Without Recurrence of Diverticulitis — 62.2; 62.9; 52.7; 64.6 percentage of subjects — p=0.047
Phase 3 N=891 Diagnosis of Acute Appendicitis: Low-dose Computed Tomography (CT) Versus Standard-dose CT
Appendicitis
Primary: Negative Appendectomy — 6; 6; 166; 180 participants
N/A N=102 Intravenous Versus Intravenous/Oral Antibiotics for Perforated Appendicitis
Perforated Appendicitis
Primary: Abscess After Appendectomy — 10; 10 number of patients
N/A N=82 Role of Intravenous Versus Home Oral Antibiotics in Perforated Appendicitis
Perforated Appendicitis
Primary: Number of Participants With Postoperative Abscess — 5; 3 Participants — p=0.7188
Phase 4 N=40 Optimal Care of Complicated Appendicitis
Appendicitis · Perforated Appendicitis · Ruptured Appendicitis
Primary: Overall Cost of Care
N/A N=36 Fast Track Appendectomy for Suppurative Appendicitis
Suppurative Appendicitis
Primary: Post Operative Length of Stay — 8.2; 23.4 Hours
N/A N=148 SpHincterotomy for Acute Recurrent Pancreatitis
Pancreatitis · Pancreas Divisum · Pancreatitis, Acute
Primary: Reduce the Risk of Subsequent Acute Pancreatitis Episodes by 33% — 32; 26 Participants
Phase 2 N=100 Dilute Povidone-iodine Irrigation vs No Irrigation for Children With Acute, Perforated Appendicitis
Acute, Perforated Appendicitis
Primary: Number of Participants With Postoperative Intra-abdominal Abscess — 6; 8 Participants
Phase 4 N=39 Comparison of Medical and Surgical Treatment of Uncomplicated Acute Appendicitis in Children
Appendicitis
Primary: Pediatric Quality of Life Inventory (PedsQL) Generic Core Scale - Parent — 91.3; 90.2 score on a scale
Phase 2 N=20 Alteplase for Percutaneous Treatment of Loculated Abdominopelvic Abscesses
Abdominal Abscess · Pelvic Abscess
Primary: Percentage of Patients Requiring Surgical Debridement for a Persistent Abscess Within 30 Days Following Initial Drainage — 3; 7 participants
N/A N=198 Is it Fair to Use Antibiotics After Laparoscopic Cholecystectomy for the Patients With Acutely Inflamed Gallbladder?
Acute Cholecystitis
Primary: Number of Participants With Infectious Postoperative Complications — 8; 7 Participants
N/A N=4,561 Chronic Gastrointestinal Sequelae of an Acute Outbreak of Bacterial Gastroenteritis in Walkerton Ontario
Irritable Bowel Syndrome
Primary: Number of Participants With Post Infectious Irritable Bowel Syndrome — 23; 114 participants
N/A N=98 Probiotics and Antibiotic Associated Diarrhea in Pediatric Complicated Appendicitis
Appendicitis · Appendicitis; Perforation
Primary: Length of Hospital Stay — 121.55; 131.69 hours
N/A N=1,552 The Comparison of Outcomes of Antibiotic Drugs and Appendectomy (CODA) Trial
Appendicitis
Primary: Patient-reported Quality of Life as Measured by EuroQol (EQ-5D) — 0.92; 0.91 score on a scale
N/A N=1,799 EHR-based Decision Support for Pediatric Acute Abdominal Pain in Emergency Care
Appendicitis
Primary: Pre to Post Ratio of Image Use — 1.13; 1.07; 1.03; 1.01 ratio of pre-post use
N/A N=26 Prevalence of Inflammatory Bowel Disease in Patients With Perianal Disease
Inflammatory Bowel Disease · Perianal Fistula · Perianal Abscess
Primary: Prevalence of Inflammation as Diagnosed by Capsule Endoscopy — 6 participants
Phase 3 N=804 Therapy of Complicated Intra-Abdominal Infections With Moxifloxacin or Ertapenem
Infection
Primary: Number of Subjects Achieving Clinical Cure at Test of Cure (TOC) Visit in the Per Protocol Population — 315; 324; 37; 23 participants
Phase 4 N=65 QL Block With Exparel in Colectomy
Laparotomy · Colectomy
Primary: Cumulative Opioid Consumption Over 48 Hours — 33; 61 morphine milligram equivalents
Phase 2 N=10 ACX-362E [Ibezapolstat] for Oral Treatment of Clostridioides Difficile Infection
Clostridium Difficile Infection
Primary: Segment 2A: Clinical Cure (CC) of Clostridioides Difficile Infection (CDI) Per Protocol (PP)/Modified Intent-to-Treat (mITT) Population — 10; 0 Participants
Phase 2 N=32 Antibiotic Instillation in Appendicitis
Complicated Appendicitis · Acute Appendicitis
Primary: Feasibility of the Use of Antibiotic Solution Instillation Following Intraoperative Diagnosis of Complex Appendicitis as Assessed by Percentage of Eligible Participants…
Phase 2 N=33 Ciprofloxacin for the Prevention of Postoperative Endoscopic Recurrence in Crohn's Disease
Crohn's Disease
Primary: Safety and Tolerability of Ciprofloxacin — 25; 11; 9; 1 Adverse events
Phase 4 N=162 Two Different Antibiotics Versus One Antibiotic for Pediatric Perforated Appendicitis
Perforated Appendicitis · Postoperative Infection
Primary: Number of Participants With a Postoperative Intra-abdominal Abscess — 19; 5 Participants
Phase 4 N=14 Effects of Gastric Acid on Colonic Microbiome
Clostridium Difficile
Primary: Shannon Diversity Index Measuring Change in Microbiome Diversity — 0.18; 0.14 Shannon index — p=0.71
N/A N=68 A Clinical Study to Limit Physiologic Intestinal FDG Uptake Uptake on PET-CT Scans
Intestinal FDG Uptake
Primary: SUVmax of FDG in Each Colonic Segment — 4.6; 4.3 SUV
N/A N=174 Evaluation of the Predictive Nature of the Postoperative CRP on Postoperative Recovery in Patients Undergoing Colorectal Resection (CRP-Track)
Colorectal Postoperative Complication
Primary: C-reactive Protein Rate — 47.9; 81.0; 50.0; 79.5 percentage
Phase 2 N=233 The Importance of Anti-anaerobic Therapy for Acute Pelvic Inflammatory Disease (PID)
Pelvic Inflammatory Disease
Primary: Clearance of Anaerobic Organisms From the Endometrium — 14; 18; 7; 1 participants — p=0.046