Clinical Trial Search

Primary: Our Primary Outcome is the Difference in VHI-10 Score at 30 Days After Injection With DAXI. — 17.81 units on a scale — p=<0.001

Primary: Unified Spasmodic Dysphonia Rating Scale (USDRS) — 2.5; 3.75 units on a scale — p=0.025

Primary: Laryngeal Adductor Reflex — 13 Participants

Primary: Pain Experienced — 2; 2; 2 score on a scale

Primary: Voice Assessment During First Visit — 0.045; 0.17; 0.13; -0.47 decibel

Primary: Adverse Response to rTMS — 0; 0 Participants

Primary: Number of Participants Who Reported Positive Effects. — 17; 20 Participants

Primary: Symptom Severity — 28.0; 18.6; 14.2; 12.3 score on a scale — p=0.01

Primary: Post Training Lung Volume Initiation — 21.07; 27.04 % vital capacity relative to rest level — p=<0.0005

Primary: Vocal Tremor Scoring System (VTSS) — 0.57; 0.57; 1; 0.43 units on a scale

Primary: Change in Baseline Cepstral/Spectral Index of Dysphonia (CSID) — 1.22; 4.45; 4.56; 3.13 score on a scale

Primary: Pitch Recognition Accuracy — 7.70 Percent agreement to reference pitch

Primary: Post-Treatment Mean in Voice Handicap Index Score — 15.00; 15.75; 18.50 score on a scale — p=0.041

Primary: Mean Global Dystonia Rating Scale Score as Measured by Blinded Rater — 3.80; 3.57; 3.71 units on a scale

Primary: Change in Quality of Life in Essential Tremor (QUEST) Questionnaire Score — 39.41; 29.50; 23.60 units on a scale

Primary: Treatment-related Changes in Vocal Intensity Will be Assessed Using Acoustic Analysis. — 3; 3; 0.26 Decibels

Primary: (Supra)Glottic Activity: Amplitude of Vibration — 37.7; 32.5; 28.8; 37.1 percentage

Primary: Toronto Western Spasmodic Torticollis Rating Scale (TWSTR) Sum Score — -6.00; -3.23 units on a scale

Primary: Dystonia Severity as Assessed by the Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) — 13; 17 scores on a scale

Primary: Speech Production: Effect Size for Treated Items — 6.84; 6.14 effect size — p=.254

Primary: Change From Baseline in MAS Score in the Primary Targeted Muscle Group (PTMG) — -0.3; -1.2; -1.4 units on a scale

Primary: Change From Baseline in VHI-10 Score After 4 Sessions of Voice Therapy — 7 score on a scale — p=.0076

Primary: Magnitude of Acoustic Amplitude Tremor and Magnitude of Acoustic Frequency Tremor — 12.91; 13.49; 12.43; 9.35 percentage of voice signal with tremor — p=0.0216

Primary: Change in Mean Length of Utterance (MLU) — 0.5387; 0.2987 Morphemes per utterance — p=<0.555

Primary: Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) — -3.0; 0.25; -2.9; -1.5 units on a scale

Primary: Change From Baseline in Burke-Fahn-Marsden Dystonia Rating Scale — 14.7 change in points on a scale

Primary: Physician Global Perception of Change - Blinded Rater 1 — 1; 1; 1; 4 Participants

Primary: Percent Compliance — 89.04; 92.44; 90.76 percentage of voicing crossing threshold

Primary: Salivary Pepsin Concentration — 158.4 ng/mL — p=0.61

Primary: Change in Speech Intelligibility at 6 Months — 0.25; -4.78 score on a scale — p=0.13