Phase 4 N=159 3 Local Anesthetics for Spinal Anesthesia in Primary Total Hip Arthroplasty
Osteoarthritis, Hip
Primary: Percentage Ambulating Early After Spinal Anesthesia — 9; 20; 35 Participants
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Phase 4 N=43 Chloroprocaine Spinal Anesthesia for Cervical Cerclage (CP Spinal)
Adverse Reaction to Spinal Anesthetic · Maternal Care for Cervical Incompetence
Primary: Time to Resolution of Motor Block — 109; 112 minutes
N/A N=23 Changes in Tissue and Cerebral Oxygenation Following Spinal Anesthesia in Neonates, Infants, and Children
Infants Undergoing Surgery
Primary: Cerebral Non-invasive Near Infrared Spectroscopy (NIRS) — 0.05 percentage change per minute
Phase 4 N=36 Spinal Versus General Anesthesia With Popliteal and Adductor Canal Blocks for Ambulatory Foot and Ankle Surgery.
Nerve Block · General Anesthesia · Spinal Anesthesia
Primary: Time Until Patient is Ready for Discharge From Post-Anesthesia Care Unit (PACU) to Home. — 81; 43.5 Minutes
Phase 4 N=183 Spinal Anesthesia With Hyperbaric Levobupivacaine 0.75% for Ambulatory Knee Arthroscopy
Disorder of Knee · Anesthesia
Primary: Probability of Motor Block — 5; 20; 27 percentage of motor block
N/A N=116 Perioperative Intravenous Lidocaine or Epidural Anesthesia on Outcomes in Complex Spine Surgery
Spine Surgery
Primary: Mean Pain Scores — 4.4; 5.3 verbal response scores — p=<0.001
N/A N=56 Study to Find Optimal Dose of Local Spinal Anesthetic (Mepivacaine) Combined With Narcotic (Fentanyl) For Knee Surgery
Arthroscopic Knee Surgery
Primary: Time From Spinal Administration to Block Regression to the S1 Dermatome in Post-Anesthesia Care Unit (PACU) — 203; 195; 156; 159 minutes
Phase 3 N=35 Minimal Effective Dose of Hyperbaric Spinal Bupivacaine for Saddle Block
Perianal Surgery
Primary: Minimal Effective Dose of Hyperbaric Bupivacaine — 1.9 milligrams
Phase 4 N=82 Spinal Anesthesia Induced Hypotension During Cesarean Section
Hypotension
Primary: Incidence of Maternal Hypotension — 10.8; 27 percentage of participants
Phase 4 N=180 Effects of General Anesthesia and Spinal-Morphine Anesthesia on Recovery and Comfort After Benign Abdominal Hysterectomy
Hysterectomy (MeSH nr: E04.950.300.399)
Primary: Duration of Hospital Stay. — 46; 50 Hours
Phase 3 N=45 Bupivacaine With Epidural Volume Extension
Spinal Anesthesia · Epidural; Anesthesia
Primary: Time Until PACU Discharge in Minutes — 135; 50 minutes
Phase 4 N=60 Spinal Anaesthesia With Levobupivacaine 0.5% and Ropivacaine 0.75% for Lower Limb Orthopaedic Surgery
Lower Limb Surgery
Primary: Duration of Analgesia — 309.83; 249.50 minutes
N/A N=429 Predict Fluid Responsiveness in Spinal Anesthesia
Hypotension and Shock · Excessive Amount of Blood / Fluid Infusion
Primary: Percentage of Participants With Systemic Hypotensions — 68; 46; 65 Participants
N/A N=30 Anesthesia During Neurophysiologic Monitoring in Scoliosis Patients
Idiopathic Scoliosis
Primary: Amplitude Required to Elicit the MEP — 307; 417 milliamperes
Phase 3 N=154 Mepivacaine Versus Low-Dose Bupivacaine For Primary Total Hip and Knee Arthroplasty
Knee Osteoarthritis · Hip Osteoarthritis
Primary: Time to Return of Lower Extremity Motor Function — 210.3; 184.7 minutes
Early Phase 1 N=229 Comparison of 0.1 and 0.05mg Intrathecal Morphine for Post-cesarean Analgesia.
Cesarean Section
Primary: Time to First Narcotic Rescue Dose in the First 24 Hours Post-cesarean Delivery. — NA; 23.5 hours
Phase 2 N=45 Spinal Anaesthesia With Chloroprocaine HCl 1% for Elective Lower Limb Procedures of Short Duration.
Short Duration Lower Limb Surgery Via Spinal Anaesthesia
Primary: Time to Regression of Spinal Block — 40.8; 39.4; 41.5 minutes
N/A N=74 Dexmedetomidine in Spinal Anesthesia
Blood Pressure · Anxiety
Primary: Incidence of Hypotension — 15; 5 participants
Phase 4 N=20 Awake Caudal Catheter vs General Anesthesia
Inguinal Hernia
Primary: Number of Participants With Return to Baseline Respiratory Function. — 11; 9 Participants
N/A N=50 Accuracy of Manual Palpation vs Ultrasound for Spinal Anesthesia
Anesthesia, Local · Infant Conditions
Primary: Intended Interspace — 1; 24; 25 Participants
Phase 2 N=110 1% Chloroprocaine(PF) vs. Bupivacaine Spinals
Return of Motor and Sensory Blockade · Anesthesia, Spinal · Decrease Discharge Time Status Post Hemorrhoidectomy
Primary: Recovery Time — 134.1; 161.9 minutes
N/A N=60 Epidural Anesthesia for Transurethral Resection of The Prostate
Epidural Catheter · Epidural Analgesia · Geriatric Cardiology
Primary: Time to Reach Sensory Block at T10 — 15.25; 10.50; 11.25 Minutes — p=0.05
Phase 3 N=40 Hyperbaric Bupivacaine Versus Hyperbaric Prilocaine 2% for Cesarean Section Under Spinal Anesthesia
Pregnant Women · Pain · Hypotension
Primary: Time to Regression of Motor Block — 180; 130 minutes
Phase 3 N=192 Wound Infusion vs Spinal Morphine for Post-caesarean Analgesia
Post Caesarean Analgesia
Primary: Duration of Effective Analgesia — 351; 380; 247 minutes
Phase 4 N=47 ED90 of 3% Chloroprocaine for Cervical Cerclage
Cerclage, Cervical
Primary: The Dose of Intrathecal (IT) Chloroprocaine That Provides Effective Anesthesia in 90% of Patients Undergoing Elective Cerclage Placement (Intraoperative Analgesic…
Phase 3 N=2,108 Regional Anesthesia and Breast Cancer Recurrence
Breast Neoplasms
Primary: Number of Participants Who Had Breast Cancer Recurrence After Breast Cancer Surgery — 111; 102 participants — p=0.84
Early Phase 1 N=70 Comparison of Chloroprocaine vs Lidocaine for Epidural Anesthesia in Cesarean Delivery
Surgical Anesthesia, Cesarean Section
Primary: The Onset Time to Surgical Anesthesia — 558; 655 seconds — p=0.10
N/A N=446 Thoraco Lumbar Vertebral Length and Bupivacaine Dosage in C-Section
Obstetric Anesthesia Problems · Bupivacaine Adverse Reaction
Primary: Hypotension Rate Among the Groups — 9; 26; 37 Participants
N/A N=154 Effect of Local Anesthetic Dose on Interscalene Block
Shoulder Arthroscopy · Interscalene Block
Primary: Handgrip Strength — 6.45; 2.98 kg
Phase 2 N=40 Estimation of the ED95 of Intrathecal Hyperbaric Prilocaine 2% With Sufentanyl for Scheduled Cesarean Delivery
Pregnant Women
Primary: Success of Anesthesia — 4; 4; 4; 1 Participants