N/A N=21 Lateral Ankle Sprain and Platelet Rich Plasma
Ankle Injuries
Primary: American Orthopedic Foot and Ankle Society Ankle-Hindfoot Scale (AOFAS) — 97.8; 98.5 units on a scale
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=36 The Effect of Additional Neurodynamic Intervention in Patients With Chronic Ankle Instability
Ankle Sprains
Primary: Pressure Pain Threshold- Anterior Talofibular Ligament — 4.19; 3.98 kg/ cm²
N/A N=9 Computed Tomography for Evaluating Supination-external Rotation Type Ankle Fractures
Supination-external Rotation Ankle Fractures
Primary: Medial Clear Space Distance in the Ankle Joint — 1.41 mm
N/A N=377 Predicting Ankle Injury Through Clinical Functional Measures in Adolescent Athletes
Other Instability, Ankle and Foot
Primary: Dynamic Balance: (Star Excursion Balance Test) — 72.3; 78.0 % of leg length
N/A N=22 Effects of Two Supervised Training Programs for the Rehabilitation of Ankle Sprains
Ankle Sprains
Primary: Ankle Functional Stability, Via the Single-leg Hop for Distance Test — 65.6; 82.8; 100.3; 101.4 Centimeters
N/A N=53 The Effect of Five-Toed Socks on Postural Control Among Active Individuals Who Have Chronic Ankle Instabilities
Ankle Sprain
Primary: The Primary Outcome Measurement for This Study Was to Determine Differences in Center of Pressure (COP) and Static Postural Control Patterns in Individuals With and…
Phase 3 N=385 A Multicenter Efficacy Study of a Diclofenac+Menthol Gel in Subjects With Ankle Sprain
Pain
Primary: Area Under the Curve From Day 1 to Day 3 (AUC1-3 Days) of Pain Intensity(PI) on Movement for Diclofenac/Methanol Gel and Placebo Gel — 276.97; 282.88 NRS Score (0 - 10…
Phase 3 N=420 TAASS-Traumeel Ointment and Gel Compared With a Topical NSAID in Athletes With Acute Ankle Sprain
Sprain of Ankle
Primary: Patient's Assessment of Ankle Pain (VAS)- Absolute Value Decrease on Day 7 — -33.00; -37.10; -37.10 Absolute value units on a scale VAS
Phase 3 N=304 5% Topical Ibuprofen (IBU) for Ankle Sprain
Ankle Injuries
Primary: Sum of Pain Intensity Difference (SPID) on Weight Bearing Over 3 Days (SPID WB0-3) — 188.9; 173.6; 165.9 units on a scale — p=0.190
Phase 2 N=271 Efficacy and Safety of Diclofenac Diethylamine 2.32% Gel in Patients With Acute Ankle Sprain
Ankle Sprain
Primary: Pain on Movement on Day 5 (Change From Baseline). A Greater Change From Baseline on Day 5 Equates to a Better Outcome. — 38.3; 35.7; 33.4 mm
N/A N=24 Balance Training vs. Balance Training w/ STARS
Ankle (Ligaments); Instability (Old Injury)
Primary: Balance — 68.7; 66.2; 87.7; 85.5 % of leg length — p=.904
Phase 4 N=270 Efficacy of Topical Indomethacin Patch Over Placebo in Ankle Sprain Pain Relief
Ankle Sprain
Primary: Sum of Pain Intensity Difference (SPID)1-3 Days — 3.981; 3.264 Score on scale — p=0.0201
N/A N=21 Internal Brace Augmented Anterior Inferior Tibiofibular Ligament Repair: Post-operative Syndesmotic Volumes.
Syndesmotic Injuries · Ligament Rupture · Bimalleolar Fractures
Primary: Syndesmotic Volumetric Ratio — 1.2; 1.1 Volumetric Ratio
N/A N=20 The Influence of Stability Boots on Gait Pattern in Healthy Adults
Rehabilitation After Ankle Injuries
Primary: ROM Ankle Joint — 31.4; 18.4; 21.2 degree
N/A N=233 A Multicenter Randomized Trial Comparing Antiglide and Lateral Plate Fixation in Ankle Fractures
Ankle Injuries
Primary: Percentage of Nonpalpable Hardware — 71; 55; 64; 66 percentage of participants
Phase 3 N=302 Voltaren Emulgel 2% Acute Ankle Sprain Non Inferiority Study
Pain
Primary: Change From Baseline in Pain on Movement (POM) on Day 5 of Treatment as Assessed by a 100 Millimeter (mm) Visual Analogue Scale (VAS) — -42.36; -43.47 mm — p=0.5950
N/A N=23 Weightbearing Assessment of Tarsal Instability
Adult-acquired Flatfoot Disorder (AAFD)
Primary: Change in Joint Motion Between Touch-down Bearing Navicular and Full-weight Bearing Navicular — 3.56; 4.36; -0.1666; -0.170 mm
N/A N=100 Associated Joint Pain With Controlled Ankle Movement (CAM) Walker Boot Wear
Pain · Ankle Injuries
Primary: The Presence and Severity of Secondary Site Pain — 31 Participants
N/A N=25 Study of Cingal® for Symptomatic Relief of Osteoarthritis of Ankle Joint
Osteoarthritis, Ankle
Primary: Numerical Rating Scale (NRS) Pain on Walking — -3.84 units on a scale — p=<0.0001
Phase 4 N=252 FS-67 in the Treatment of Pediatric Patients With Ankle Sprain
Ankle Sprain
Primary: Primary: Sum of Pain Intensity Difference (SPID) at 8-hours (SPID8) Upon Monopodal Weight Bearing. — 107.19; 89.13 units on a scale — p=0.137
N/A N=11 Platelet Rich Plasma Injection in Pilon Fractures
Fracture
Primary: Intra-articular Inflammatory Biomarkers at the Time of Definitive Fixation — 54.89; 163.01; 2479.17; 2511.32 pg/ml
Phase 3 N=242 Evaluate the Efficacy and Safety of Diclofenac Diethylamine 2.32% Gel Applied Twice or Three Times Daily in Patients With Acute Ankle Sprain
Grade I/II Ankle Sprain
Primary: Measure: Pain on Movement on Day 5 (Change From Baseline). — 49.1; 49.7; 25.4 mm
N/A N=118 Effects of Foot Strengthening on the Incidence of Injuries in Long Distance Runners
Leg Injuries
Primary: Number of Participants With Running Related Lower Limb Injuries — 20; 8 Participants
Phase 4 N=278 Open Label Comparative Study On Celecoxib Efficacy And Safety Vs Non-Selective NSAID In Acute Pain Due To Ankle Sprain
Ankle Sprain
Primary: Change From Baseline at Day 3 in Pain Visual Analog Scale (VAS) - Per Protocol Population — -44.88; -40.76 scores on a scale
Phase 3 N=205 Efficacy and Safety of Diclofenac Sodium Topical Gel 1% Applied Four Times Daily in Subjects With Acute Ankle Sprain
Acute Ankle Sprain
Primary: Pain on Movement — 25.6; 61.2 mm
N/A N=111 Brace Versus Casting in Pediatric Low Risk Ankle Fractures
Ankle Fracture
Primary: Functional Outcome as Measured by the Activities Scale for Kids at 4 Weeks From the Time of the Initial Injury — 85.3; 91.3 percentage of questions
Phase 2 N=39 Bracing and Strengthening for Posterior Tibial Tendon Dysfunction
Posterior Tibial Tendon Dysfunction
Primary: Foot Function Index(FFI) — 16.0; 12.7; 8.1; 8.3 units on a scale
N/A N=22 Iterative Design of Custom Dynamic Orthoses to Reduce Articular Contact Stress
Ankle Fractures · Post-traumatic Osteoarthritis · Osteoarthritis Ankle
Primary: Joint Contact Stress Time Exposure (Model Estimated) — 4.44; 3.97; 4.08; 4.25 MPa-s/gait cycle
Phase 2 N=50 Efficacy of 3 Weekly Injections of Hyaluronate in Patients With Ankle Osteoarthritis
Osteoarthritis
Primary: Change From Baseline in the Ankle Osteoarthritis Scale (AOS) Score at 6 Months — 2.3 score on a scale — p=<0.05
N/A N=19 Balance Training With tDCS for CAI
Ankle Injuries and Disorders
Primary: Static Postural Balance — 57.0; 55.9 CM/S