Clinical Trial Search

Primary: Eustachian Tube Dysfunction (ETD) Symptom Visual Analog Scale (VAS) - Total Score — 59.6 score on a scale

Primary: Reduction in Pain — 6.4; 6.2; 2.6; 6.0 score on a scale

Primary: Improvement in NOSE Score — 54.8 units on a scale — p=<0.0001

Primary: Number of Subjects With Complete Normalization of Abnormal Tympanometry, Regardless of Additional Treatment — 7; 12 participants — p=0.18

Primary: Number of Subjects With Post-surgical Otorrhea — 383; 118 Participants

Primary: Resolution of Otitis Media Symptoms — 14.2; 16.5; 7.5; 14.1 units on a scale — p=.002

Primary: Narcotic Usage — 4.9; 2.0 Pills

Primary: Number of Subjects With Adverse Events — 19; 14; 4 Participants

Primary: Otoscopic Examination: Tympanic Membrane — 6; 8; 8 Participants

Primary: Change in Total Nasal Symptom Score (TNSS) at 4 to 6 Weeks — 3.5 score on a scale

Primary: Change in Middle Ear Effusion Over Four Weeks Following an Episode of Acute Otitis Media — 26; 16; 12; 22 Ears — p=0.02

Primary: Number of Ears With Otorrhea (Drainage From the Middle Ear) — 8 affected ears

Primary: Number and Type of Contacts With Health Care Providers — 45; 14; 5; 3 Participants

Primary: Severity of Symptoms of Otitis Media — 2.0; 2.0 units on a scale

Primary: Otoscopic Examination: Auricle and Meatus — 1 ears

Primary: Number of Subjects Considered a Clinical Cure at Day 8 — 91; 63 Participants

Primary: Control Status of Patients With Rhinosinusitis — 19.5; 36.8; 43.7 percentage of participants

Primary: Change in Rhinosinusitis Disability Index (RSDI) Score — -8.000; -14.82 units on a scale — p=0.505

Primary: Change From Baseline NOSE Score — 53.3; 48.1; 53.5 units on a scale — p=<0.0001

Primary: Number of Antibiotic Prescriptions — 140; 115; 6; 7 Emergency department encounters

Primary: Lactobacillus Rhamnosus GG in Middle Ear Effusion and Adenoid Tonsil — 4; 1 Samples — p=0.05

Primary: Percentage of Participants With >=3 Diagnostic Rating Using Radlex Scale — 92.63 percentage of participants

Primary: Change in Computed Tomography (CT) Score After Treatment — -.64; -.63; -.5; -.5 units on a scale

Primary: Percentage of Participants Who Were Treatment Failures — 24.6; 44.8 percentage of treatment failures

Primary: Percentage of Participants Who Were Treatment Failures. — 21.3; 45.5 percentage of treatment failures

Primary: Absence of Middle Ear Fluid by Pneumatic Otoscopy, Right Ear — 1; 0 participants

Primary: Total Symptoms Score (TSS) — 0.503; 0.843 scores

Primary: Change in Reflective Total Nasal Symptom Score (rTNSS) — -5.1 units on a scale — p=<0.0001

Primary: Skin Irritation — 0.22; 0.20; 0.13; 0.11 score on a scale

Primary: Snoring Severity Scale — -4.1 units on a scale — p=< 0.0001