Clinical Trial Search

Primary: Change in Total Number of Episodes of Apnea/Breathing Pauses During Intervention and Without Intervention — 284.13; 174.27 breathing pauses

Primary: Survival Without Bronchopulmonary Dysplasia (BPD) — 346; 320 Participants

Primary: Number of Participants Who Were Intubated — 6; 8 Participants

Primary: Number of Participants With Successful Wean Off CPAP at the First Attempt — 31; 30 Participants

Primary: Intubation — 3; 7 participants

Primary: Number of Days on NCPAP or Mechanical Ventilation — 17.3; 12.3 days

Primary: Number of Days Being Intubated — 12.4; 6.2 days

Primary: Changes in the Measurements of Functional Residual Capacity (FRC) in Randomized Premature Infants — 12.6; 6.4; 27.2; 17.1 mL — p=<0.05

Primary: Time to First Event: Pulse Oximetry at 95%, or Successful Intubation — 106; 169 seconds

Primary: Duration of Invasive Mechanical Ventilation — 6.3; 7.8; 7.3 day

Primary: Ventilation/Perfusion Mismatch — 1.2 difference in right shift (kPa) — p=0.02

Primary: Alveolar Volume — 500.2; 418.1 mL — p=<0.05

Primary: Number of Patients With Prolonged Desaturation — 54; 53 Participants — p=0.38

Primary: Effect of CPAP on Neurocognitive Function: E/F Function- SWMT-OMD — 0.035; -0.074; 0.072; 0.018 score on a scale — p=0.0074

Primary: Number of Participants With Slowing of Fetal Growth by 33% or More During the Last Trimester — 8; 8 Participants — p=0.92

Primary: Occurrence of Apnea — 25; 12; 80; 104 Participants — p=0.0104

Primary: Time Between Onset of Apnea and the Drop in 95% Oxyhemoglobin Saturation Levels — 227.65; 133.68 seconds — p=<0.0001

Primary: Participant Providing Feedback — 26 Participants

Primary: Number of Participants With a Negative Obstructive Sleep Apnea (OSA) Home Sleep Test Result — 61 Participants

Primary: Duration of Home Oxygen Therapy — 66; 58 Days — p=<0.03

Primary: Number of Participants Who Required Intubation — 26; 15 Participants

Primary: Mortality Before Hospital Discharge — 11 Participants

Primary: Episodes of Intermittent Hypoxia Per Hour — 3.6; 8.4; 3.8; 8.2 Events per hour — p=<0.05

Primary: Need for Endotracheal Ventilation in the First 72 hs of Life — 34; 25 participants — p=<0.05

Primary: Pharyngeal Phase Dysphagia — 7; 7 Participants

Primary: Number of Participants With Adverse Events as a Measure of Safety and Feasibility — 3; 8; 4; 12 Participants

Primary: Difference Between Optimal Pressure (cm H2O) Derived From APAP run-in Period Versus Result of CPAP Titration Study — 7.3; 9.4 cmH2O

Primary: Positive Berlin Questionnaire Indicative of Sleep Disordered Breathing — 1343; 96 participants — p=0.001

Primary: Composite Perinatal Morbidity — 277; 203; 221; 45 participants

Primary: Intermittent Hypoxemia (IH) Events Per 8 Hours of Monitoring Time — 2.2; 1.2 IH events per 8 hours of monitoring time