N/A N=1,516 Brain Injury Rehabilitation Improving the Transition Experience
Traumatic Brain Injury
Primary: Participation Assessment With Recombined Tools - Objective 17 (PART-O-17) — 1.30; 1.33 units on a scale — p=0.44
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 2 N=122 Brain Tissue Oxygen Monitoring in Traumatic Brain Injury (TBI)
Severe Traumatic Brain Injury
Primary: Fraction of Time That Brain Oxygen Levels Are Below the Critical Threshold of 20 mm Hg . — 0.15; 0.44 Proportion
N/A N=120 Neurocognitive Evaluation of Mild Traumatic Brain Injury in the Hospitalized Pediatric Population
Mild Traumatic Brain Injury · Concussion
Primary: The Feasibility of Inpatient Bedside Neurocognitive Testing of Pediatric Patients With Minor Traumatic Brain Injury. — 120 participants
N/A N=6 Deep Brain Stimulation for the Treatment of Traumatic Brain Injury
TBI (Traumatic Brain Injury)
Primary: Percent Change in Trail Making Test Part B Time to Completion — -25.6 percent change in time
N/A N=35 Neural Bases of Cognitive Rehabilitation for Brain Injury
Brain Injury
Primary: Change From Baseline on a Composite Measure (Z-score) of Attention, Working Memory, and Executive Functions — 0.26; .01 Change to Z (composite) score
Phase 2 N=18 Hyperbaric Treatment of Traumatic Brain Injury (TBI)
Traumatic Brain Injury
Primary: Number of Participants With Improved Cerebral Perfusion — 8 Participants
N/A N=49 Training in Goal-directed Attention Regulation for Individuals With Brain Injury
Brain Injury
Primary: Self-report — 7.79; 6.49; 7.61; 7.73 units on a scale
N/A N=18 Brain Markers of Improvements in Cognitive Functioning
TBI (Traumatic Brain Injury) · Brain Injuries · Stress
Primary: Composite Score of Attention and Executive Functioning From a Neurocognitive Test Battery — 0.18; -0.06 units on a scale
Phase 1 N=52 Behavioral and Neuroimaging Changes After Cognitive Rehab in Traumatic Brain Injuries (TBI) and Mild Cognitive Impairment (MCI)
Mild Cognitive Impairment · Alzheimer's Disease · Traumatic Brain Injury
Primary: Memory Test Accuracy on Trained Stimuli — 53.9; 37.6; 48.9; 37.3 Percent correct
Phase 2 N=50 Treatment of Traumatic Brain Injury With Hyperbaric Oxygen Therapy
Brain Injury, Chronic
Primary: Computer Cognitive Test Scores - ImPACT Verbal Memory — 70.48; 74.21; 78.12; 75.36 units on a scale
N/A N=23 Optimizing Cognitive, Environmental, and Neuromotor Stimulation in Traumatic Brain Injury
Traumatic Brain Injury · Dementia Alzheimers · Military Activity
Primary: Change in Executive Functioning as Assessed by the Trail Making Test — -9.2; 24.7 change in seconds — p=.323
N/A N=108 Brain Training to Enhance Frontal Lobe Reasoning
Traumatic Brain Injury
Primary: Glasgow Outcome Scale-Extended — 6.21; 6.30 units on a scale
N/A N=32 Effects of Bright Light Therapy in Mild Traumatic Brain Injury
Concussion, Mild · Post-Concussion Symptoms · Sleep Problems
Primary: Performance on Multiple Sleep Latency Test (MSLT) — 6.67; 7.32; 6.73; 7.88 minutes
N/A N=68 Light Therapy for Moderate Traumatic Brain Injury
Moderate Traumatic Brain Injury (TBI)
Primary: Safety and Feasibility of Applying Light Therapy After Moderate TBI — 24; 19 Participants
N/A N=55 Cognitive-Behavioral Therapy for Veterans With TBI
Insomnia · Traumatic Brain Injury
Primary: Change in Insomnia Severity — 8.833; 7.810; 9.625; 8.364 score on a scale
N/A N=31 Enhancing the Transition From Hospital to Home for Patients With Traumatic Brain Injury and Families
Brain Injuries, Traumatic · Transitional Care · Family Members
Primary: Change in Quality of Life as Measured by the Short Form-36 (SF-36) — 47.97 score on a scale
N/A N=40 Transcranial Direct Current Stimulation for the Treatment of Deficits After Traumatic Brain Injury
Traumatic Brain Injury · Post Concussive Symptoms · Depression
Primary: Examiner Score — 0.617; 0.907; 0.865; 1.155 score on a scale
N/A N=24 Traumatic Brain Injury and Risk for Chronic Traumatic Encephalopathy
CTE · TBI (Traumatic Brain Injury)
Primary: Distribution Volume Ratio (DVR) — 1.30; 1.39; 1.26; 1.34 Distribution Volume Ratio (DVR) — p=<0.02
N/A N=21 Translational Research Examining Acupuncture Treatment in Traumatic Brain Injury
Traumatic Brain Injury
Primary: Cerebral Blood Flow Velocity in the Left (L) and Right (R) Middle Cerebral Artery (MCA), Internal Carotid Artery (ICA), and Basilar Artery (BA). — 3.2; 6.7; 4; 12.7 ml/sec
N/A N=15 Q-collar and Brain Injury Biomarkers
Concussion
Primary: Longitudinal DTI Changes — 0.000809; 0.000760; 0.000763; 0.000843 voxels
Phase 2 N=50 Translocator Protein and Inflammation After Traumatic Brain Injury
Traumatic Brain Injury (TBI) · Healthy
Primary: Receptor Binding (Vt) — 2.53; 2.21; 3.21; 3.22 mL/cm^3
N/A N=212 Quantitative Automated Lesion Detection of Traumatic Brain Injury
Traumatic Brain Injury
Primary: Performance on Trail-making Test, Part B — -0.02; 0.18 z-score — p=< 0.04
N/A N=33 rTMS to Improve Cognitive Function in TBI
Traumatic Brain Injury
Primary: Trail Making Test Part B — 52.1; 45.3; 52.9; 50.8 T-score
Phase 4 N=26 Methylphenidate for Attention Problems After Pediatric TBI
Traumatic Brain Injury · TBI · ADHD
Primary: Parent Outcome-Vanderbilt ADHD Parent Rating Scales (VADPRS) — 1.10; 1.47; .84; 1.14 units on a scale
Phase 2 N=61 A Study of Modified Stem Cells in Traumatic Brain Injury (TBI)
Traumatic Brain Injury
Primary: Change From Baseline in Fugl-Meyer Motor Scale (FMMS) Score at Week 24 Among All Patients — 6.0; 11.0; 8.1; 2.3 Change in score on a scale from baseline — p=0.0401
N/A N=97 Traumatic Brain Injury (TBI) Screening Instruments
Brain Injury
Primary: Responses From the TBI Clinical Reminder — 61; 88 percentage of participants
N/A N=6 Team Based Initiative Support
Traumatic Brain Injury
Primary: Number of Participants Who Reported 5 Themes — 6; 6; 6; 6 participants
Phase 4 N=15 Anterior Pituitary Hormone Replacement in Traumatic Brain Injury
Growth Hormone Deficiency · Traumatic Brain Injury
Primary: Maximum Oxygen Uptake at Baseline. — 29.0 mL/kg/min
N/A N=98 Study of PTSD in Military Veterans Who Have Suffered Traumatic Brain Injuries
PTSD · TBI
Primary: Change in Diagnostic and Statistical Manual of Mental Disorders IV Clinician-Administered PTSD Scale DSM IV-(CAPS) — 73.13 units on a scale
N/A N=50 Valproate for Mood Swings and Alcohol Use Following Head Injury
Traumatic Brain Injury (TBI) · Alcoholism
Primary: Severity of Affective Lability Based on Shortened Agitated Behavior Scale — 9.22; 9.39 units on a scale