N/A N=101 Gender Difference in Response to Caffeine in Children and Adolescents
Healthy
Primary: Peak Heart Rate After 2 mg/kg of Caffeine — 73.6; 73.2; 79.6 beats per minute — p=<0.05
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=109 Remote Guided Caffeine Reduction
Caffeine Dependence · Anxiety · Sleep Disturbance
Primary: Number of Participants With Treatment Retention as Assessed by Number of Participants With Completed Assessments — 51; 51; 50; 46 Participants
Early Phase 1 N=65 Caffeine and Neurologic Recovery Following Surgery and General Anesthesia
Pain, Postoperative
Primary: Cumulative Opioid Consumption: Postoperative Opioid Consumption, Oral Morphine Equivalents (mg) — 77; 51 oral morphine equivalents (mg) — p=0.092
Phase 2 N=23 Caffeine and Cocaine
Cocaine Dependence
Primary: Visual Analog Scale Subjective Rating of Drug Effects — 8.65; 9.85; 13.65; 10.43 units on a scale
Phase 4 N=8 A Study to Determine if Caffeine Accelerates Emergence From Anesthesia
Anesthesia
Primary: Waking Time - Re-establishment of the Gag Reflex. — 16.45; 9.57 minutes — p=0.002
Phase 3 N=98 Effects of Caffeine on Intermittent Hypoxia in Infants Born Preterm
Hypoxia
Primary: Episodes of Intermittent Hypoxia Per Hour — 3.6; 8.4; 3.8; 8.2 Events per hour — p=<0.05
N/A N=205 Evaluating the Role of Expectations in Response to Caffeine Consumption: An RCT
Caffeine · Affect · Cognitive Ability, General
Primary: Mood State Score on POMS-2 Test — 2.63; 14.08; 2.19; 2.54 units on a scale
N/A N=16 Effect of Oral Caffeine and L-Citrulline Supplementation on Arterial Function in Healthy Males
Hypertension · Healthy
Primary: Aortic Blood Pressure — 5; 6; 4; 4 mmHg — p=<0.001
Phase 4 N=8 A Study to Determine if Caffeine Accelerates Emergence From Propofol Anesthesia
Anesthesia
Primary: Waking Time - Time Between Terminating Anesthesia and Subject Opening Eyes.
Phase 2 N=70 Treatment for Cannabis Withdrawal and Dependence
Cannabis Dependence
Primary: Change From Week 0 in Cannabis Use Using Urinary CN-THCCOOH Levels at Week 8 — -334.21; -359.95 ng/mg
Phase 2 N=41 Efficacy of Caffeine Injection as an Adjuvant to Opioid Therapy in Cancer Pain
Cancer · Pain
Primary: Numeric Rating of Scale (From 0 to 10) of Pain and Possible Side Effects (Drowsiness, Confusion, Nausea) of Opioids — 2.22; 3.10; 2.83; 3.05 scores
N/A N=10 Ketone Production With Acute Caffeine Intake
Healthy Adults
Primary: Plasma Acetoacetate Concentrations — 26.06; 30.99; 32.10 µmol/L
Phase 4 N=21 Early Versus Routine Caffeine Administration in Extremely Preterm Neonates
Caffeine
Primary: Intubation — 3; 7 participants
Phase 4 N=40 Effects of Modafinil in Methamphetamine Dependence
Methamphetamine Dependence
Primary: Percentage of Participants With Methamphetamine-positive Urine Drug Screens — 85; 65 Percentage of participants
Phase 2 N=30 Caffeinol Hypothermia Protocol
Acute Ischemic Stroke
Primary: Number of Participants With Symptomatic Intracerebral Hemorrhage — 0 participants
Phase 1 N=9 Caffeine for Hypoxic-Ischemic Encephalopathy
Hypoxic-Ischemic Encephalopathy
Primary: Area Under Plasma Concentration-time at Time t (AUC0-t) for Caffeine — 1137.36; 1177.94; 2213.26; 2768.25 mg*hr/L
Phase 4 N=61 Oral Caffeine Use for Pain Management in AIS Patients After Spinal Fusion
Adolescent Idiopathic Scoliosis
Primary: Total Post Operative Oral Morphine Milligram Equivalents (MME)/Kilogram (Kg) for Hospital Stay — 0.83; 0.92 MME/Kg
Phase 3 N=347 Caffeine's Effect on Regadenoson Administration With Single Photon Emission Computed Tomography (SPECT) Myocardial Perfusion Imaging (MPI)
Coronary Artery Disease (CAD)
Primary: Change in Number of Reversible Defects — 0.67; 1.01; 1.00; 0.80 Reversible Defects — p=<0.001
Phase 2 N=66 Clinical and Neurobiological Effects of Cannabis Dependence in Young Adults
Cannabis Dependence · Cannabis Withdrawal
Primary: Withdrawal Symptom Severity on the Marijuana Withdrawal Checklist (MWC) at 28 Days Following Single Dose Administration of Rimonabant or Placebo, or Commencement of…
N/A N=24 Dextro-Amphetamine Versus Caffeine in Treatment-resistant OCD
Obsessive-Compulsive Disorder
Primary: Number of Subjects With Clinical Global Impressions Scale - Improvement (CGI-I) Score of 1 or 2 — 6; 7 participants
Phase 2 N=31 Carvedilol for Psychostimulant Dependence
Cocaine Dependence · Cocaine Withdrawal
Primary: Urine Toxicology Screens — 38.33; 41.85 percentage of cocaine negative urines — p=0.05
Phase 2 N=154 Acute and Residual Effects of Caffeinated Beer
Neurobehavioral Manifestations · Drug Related Sleep Disturbance · Alcohol Intoxication
Primary: Lane Position Deviation — -1.25; -1.36; -1.22; -1.21 feet
Phase 2 N=10 Evaluation of Coffee Therapy for Improvement of Renal Oxygenation
Type1diabetes · Type1 Diabetes Mellitus · Diabetic Kidney Disease
Primary: Renal Oxygenation — 22.4; 22.5 s^-1
Phase 2 N=12 Effects of Caffeine and Intermittent Hypoxia on Leg Function in Human Spinal Cord Injury
Spinal Cord Injuries
Primary: 10 Meter Walk Time — -5.0; -4.9; -4.6; -5.5 Seconds
N/A N=112 The Effects of Caffeinated Coffee on Intraocular Pressure
Primary Open Angle Glaucoma
Primary: Change in Intraocular Pressure at 60 Minutes — 1.51; 0.52 mm Hg
Phase 4 N=74 MRI and Neurodevelopment in Preterm Infants Following Administration of High-Dose Caffeine
Apnea of Prematurity · Intraventricular Hemorrhage · Brain Injury
Primary: White Matter Microstructural Maturation — 1.43; 1.42 apparent diffusion coefficient
N/A N=16 Acute Effects of Coffee on Appetite and Inflammation Markers, Glucose Metabolism and Energy Intake
Health
Primary: Ghrelin Total Area Under the Curve — 2669; 2593; 2672 ug*h/mL
Phase 2 N=12 Cognitive Behavioral Therapy and the Nicotine Transdermal Patch for Cannabis Dependence and Nicotine Dependence
Cannabis Dependence · Nicotine Dependence
Primary: Cigarette Use — 12.6; 2.1 cigarettes/day
Phase 2 N=60 Caffeine/Propranolol Intervention for Acute Migraine
Migraine Disorders
Primary: Percentage of Participants Reporting Pain Relief at 2 Hrs Post First Administration of Caffeine/Propranolol (Defined as a Decrease in Headache Pain Intensity From Severe…
Phase 2 N=73 Effectiveness of Modafinil and D-amphetamine in Treating Cocaine Dependent Individuals
Cocaine-Related Disorders
Primary: Cocaine Use as Assessed by the Treatment Effectiveness Score (TES), Which is the Total Number of Cocaine-negative Urines During Treatment — 9.25; 6.09; 6; 4.91 number of…