Phase 4 N=21 Symptom Management After Breast Cancer Surgery
Neuropathic Pain · Postmastectomy Pain
Primary: Change in Pain Intensity on an 11-point Scale From Baseline to 12 Weeks — 4.0 units on a scale
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Phase 3 N=65 An Implantable Spinal Cord Stimulation Pain Management System
Chronic Pain · Pain, Intractable · Pain
Primary: Change in Visual Analog Scale (VAS) Score From Baseline to 2 Week Post Initial Fitting. — 35 participants with > 50% VAS improvement
N/A N=575 Persistent Pain After CS Delivery
Persistent Pain After Delivery
Primary: Persistent Pain-PERCEIVED STRESS Scores Stratified by the Rate of Recovery — 11.4; 12.9; 15.4 units on a scale — p=<0.01
Phase 3 N=140 Evaluation in the Treatment of Neuropathic Pain Post Breast Surgery
Breast Cancer Patient
Primary: Change in Neuropathic Pain Score at 2 Months (Numeric Rating Scale 0-10) — 4.1; 4.6 units on a scale
N/A N=38 Project Relief: Developing Brain Stimulation as a Treatment for Chronic Pain
Chronic Pain · Chronic Lower Back Pain · Back Pain
Primary: Changes in Patient Reported Pain and Discomfort — 47; 13; -30; -18 percent change from baseline
N/A N=25 Sensory Testing of Multiple Forms of Spinal Cord Stimulation for Pain
Chronic Pain · Failed Back Surgery Syndrome · Complex Regional Pain Syndromes
Primary: Spinal Cord Stimulation (SCS)-Induced Changes in Temporal Summation (TS) — 3.67; 3.33; 3.67; 3.33 score on a scale — p=0.2375
N/A N=70 Auricular Vagus Nerve Stimulation for Chronic Pain
Low Back Pain
Primary: Low Back Pain Intensity — 1.24; 1.73 units on a scale
Phase 2 N=19 Transcranial Magnetic Stimulation for Treating Women With Chronic Widespread Pain
Fibromyalgia · Chronic Pain · Depression
Primary: Gracely Box Intensity Rating Scale — 13.18; 14.43; 10.64; 13.00 units on a scale
N/A N=779 Acupuncture Approaches for Chronic Pain
Chronic Pain · Osteoarthritis · Neck Pain
Primary: Pain Interference as Measured by the Brief Pain Inventory (BPI) (Intent to Treat Model) — 6.0; 6.1; 5.1; 4.8 Units on a Scale — p=0.0691
N/A N=109 Self-Management Interventions for Chronic Pain Relief With Cancer Survivors
Chronic Pain
Primary: Change in Pain Intensity — -1.61; -1.35 score on a scale — p=0.809
Phase 2 N=16 Dysport in Post-Surgical Neuralgia
Chronic Scar Pain
Primary: Time to Onset of Effect in the Spontaneous Numerical Rating Scale (NRS) Score — 4.41; 15.11; 29.45; 0.65 days
N/A N=18 High Rate Spinal Cord Stimulation (SCS) for Chronic Pain
Chronic Pain
Primary: Change in Back Pain Intensity — 20.9; 25.6 Percent Change From Baseline — p=0.74
Early Phase 1 N=22 Developing Brain Stimulation as a Treatment for Chronic Pain in Opiate Dependent
Chronic Pain · Opiate Dependence · Lower Back Pain
Primary: Change in Quantitative Pain Testing Following Active TMS Compared to Baseline — 1.4; .3 Change from Baseline (degrees C) — p=.83
N/A N=55 Pain and Function After Orthopedic Surgery
Chronic Pain
Primary: Self-reported Pain Intensity — 3 units on a scale
N/A N=423 Neuropathic Pain After Orchidectomy and Sex Reassignment Surgery
Neuropathic Pain · Phantom Pain · Sex Reassignment Surgery
Primary: Incidence of Phantom Pain — 6; 0 Participants — p=0.013
N/A N=11 Capsaicin 8% Patch for Spinal Cord Injury Neuropathic Pain
Spinal Cord Injuries · Neuropathic Pain
Primary: Change in Pain Relief With Visual Analog (VAS) Pain Scale — 3.586; 5.494; 4.041; 5.677 score on a scale
N/A N=60 Sacroiliac (SI) Screws: The Effect of SI Screw Removal on Patient-Reported Pain and Functional Outcomes
Sacroiliac Joint · Pain · Pelvis
Primary: Post-operative Pain Within 6 Months After Iliosacral Screw Removal Using the Brief Pain Inventory (BPI) — 3.7; 4.7 units on a scale — p==0.57
N/A N=26 Surgical Treatment of Post-surgical Mastectomy Pain Utilizing the Regenerative Peripheral Nerve Interface
Post-Mastectomy Chronic Pain Syndrome
Primary: Change in Pain Level — 6.9; 0.6; 4.4; 2.5 score on a scale
N/A N=50 Electrical Skin Conductance Monitoring as an Assessment of Post Operative Pain Scores
Postoperative Pain
Primary: Numeric Pain Rating Scale — 2.0; 2.7; 2.9 units on a scale
N/A N=21 Transcranial Alternating Current Stimulation in Back Pain- Pilot Sudy
Chronic Low Back Pain
Primary: Change in Heart Rate Variability Before and After 40-minute Stimulation — 0.206; -0.01 ms^2 — p=.319
N/A N=80 Mechanisms of Affective Touch in Chronic Pain
Fibromyalgia
Primary: Chronic Pain Intensity Using the Chronic Pain Grade Questionnaire — 66.0; 16.8 score on a scale
N/A N=92 Past Pain Experience and Perception of Experimental Pain
Schizophrenia · Major Depression
Primary: Visual Analog Scale Evaluation for the Pre-fixed Pressure Test — 2.8; 2.1; 1.2 units on a scale — p=0.121
N/A N=100 Mechanisms of Sleep Disruption Hyperalgesia
Sleep Deprivation · Pain
Primary: Spinal Sensitization as Assessed by Area of Secondary Hyperalgesia (2HA) After Two Nights of Uninterrupted Sleep and Two Nights of 8 Forced Awakenings — 1276.25…
N/A N=114 Behavioral Treatments for Chronic Pain
Intractable Pain
Primary: Brief Pain Inventory — 4.5; 5.1 units on a scale — p=.27
N/A N=20 VANISH for Chronic Low Back Pain
Chronic Low-back Pain
Primary: Assessment of Opioid Use Via Subject Report — 47.5; 21.75 morphine milligram equivalent
N/A N=5,308 Matrifen® for Therapy of Severe Chronic Pain®
Severe Chronic Pain
Primary: Patient's Assessment of Pain Severity Score — 7.12; 3.32 Units on a scale
Phase 2 N=29 Low Dose Naltrexone for Chronic Pain From Arthritis
Osteoarthritis · Arthritis, Rheumatoid · Arthritis, Psoriatic
Primary: Brief Pain Inventory - Pain Interference — -23; -22 units on a scale — p=0.90
Phase 4 N=144 Treating Phantom Limb Pain Using Continuous Peripheral Nerve Blocks: A Department of Defense Funded Multicenter Study
Phantom Limb Pain
Primary: "Average" Phantom Limb Pain Intensity 4 Weeks Following Initiation of an Ambulatory Continuous Peripheral Nerve Block (as Measured by the Numeric Rating Scale Within the…
N/A N=811 Learning to Apply Mindfulness to Pain
Chronic Pain
Primary: Change in the Brief Pain Inventory (BPI) Interference Score From Baseline, Over the 12-month Follow-up Period. — 4.8; 4.5; 5.2 score on a scale — p=0.031
N/A N=69 High Pain Intervention in Cesarean Sections
Other Chronic Postoperative Pain
Primary: Severity of Acute Pain — 46; 31 mm — p=0.05