Clinical Trial Search

Primary: Mean Percentage of Cocaine-positive Urines Over Course of 12 Week Treatment in Subgroup Achieving Abstinence at Baseline — 31; 28; 47; 35 Mean % of cocaine-positive urines

Primary: Three Weeks of Continuous Cocaine Abstinence as Measured by Urine Toxicology and Self Report Based on Time Line Follow Back — 13; 7 participants — p==.05

Primary: Urine Toxicology Screens — 38.33; 41.85 percentage of cocaine negative urines — p=0.05

Primary: Cocaine Use Over Time — 0.01; 0.007; -0.01; 0.007 slope (change in prob of coc-pos utox/d) — p=<0.05

Primary: Percent Days Abstinent From Cocaine - Self Report — 72.9; 72.9; 59.3 percentage of days — p=.10

Primary: Last Three Weeks of Cocaine Abstinence Based on Urine Toxicology Results and Self Reported Use — 7; 18; 30 percentage of participants

Primary: Cocaine Self-administration — 0; 0; 0; 2.2 Number of doses purchased

Primary: Abstinence (Weeks 10 - 11) — 4; 7 Participants

Primary: The Number of Participants Who Achieved Abstinence From Cocaine During the Last Three Weeks of the Trial — 2; 2 participants — p==0.97

Primary: Urine Assay for Benzoylecgonine (BE), the Primary Metabolite of Cocaine. — 33.3; 31.7 Percentage of Participants

Primary: Reinforcing Effects of Cocaine — 1.4; 4; 4.5; 0.7 number of times subjects chose cocaine

Primary: Cocaine-positive Urine Results — 86.5; 92.4 percentage of BE urine tests

Primary: Three Weeks of Cocaine Abstinence at End of Study — 9; 0 Participants

Primary: Abstinence — 5; 9 participants

Primary: % Urine Samples Negative for Cocaine — .67; .74 percentage of positive urine samples

Primary: Cocaine Use as Assessed by the Treatment Effectiveness Score (TES), Which is the Total Number of Cocaine-negative Urines During Treatment — 9.25; 6.09; 6; 4.91 number of…

Primary: Proportion of Subjects in Each Treatment Group Abstinent During the Last 2 Weeks of Treatment. — 7; 5 participants

Primary: Cocaine Self-administration — 2.5; 4.8 cocaine choices/participant

Primary: Subjective Stress Response TSST — 5.33; 5.28; 2.05; 2.13 units on a scale

Primary: Cocaine Use Days as Measured by Self-report, Corroborated by Thrice-weekly Urine Drug Screens — 6.6; 7.2; 7.7 days of cocaine use

Primary: Number of Times Cocaine Was Selected in the Presence of a Monetary Reward Alternative — .34; .24; 4.31; 3.9 Cocaine Choices

Primary: Endothelin-1 Levels — 2.15; 2.063; 1.956 pg/ml

Primary: The Number of Times Cocaine Was Selected in the Presence of a Monetary Reward Alternative — 0.06; 0.94; 0.75; 0.88 cocaine choices

Primary: the Adult ADHD Rating Scale (AARS) (30% Reduction) — 50 percent of participants

Primary: Attentional Bias as Assessed by Score on the Stroop Task — -13.90333; 27.118; -9.361269; 15.35407 milliseconds

Primary: Number of Participants Maintained on the Maximum Lisdexamfetamine Daily Dose. — 12 Participants

Primary: The Number of Times Cocaine Was Selected in the Presence of a Monetary Reward Alternative — 2.75; 1.38; 1.38; 4.75 cocaine choices

Primary: Number of Times Cocaine Was Selected in the Presence of a Monetary Reward Alternative — 1.0; 0.1; 3.4; 3.9 Number of Cocaine Choices

Primary: Cocaine Use/Treatment Effectiveness Score (TES) — 6.6; 8.3; 29 percentage of negative urines

Primary: Number of Participants Who Are Cocaine Abstinent During the Last 2 Weeks of Treatment (Weeks 8-9), as Assessed by Urine Test — 0; 4; 2 Participants