Phase 2 N=123 Modafinil Combined With Cognitive Behavior Therapy to Treat Cocaine Addiction - 1
Cocaine Dependence
Primary: Number of Cocaine Non-use Days — 10.1; 17.1; 9.3; 14.1 Number of Days
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 1 N=45 Investigation of Cocaine Addiction Using mGluR5 PET and fMRI
Cocaine Dependence
Primary: Regional Availability of Metabotropic Glutamate Type-5 Receptors (mGluR5) — 36.48; 32.19; 25.67; 22.41 mL*cm^3 — p=0.035
Phase 2 N=81 Medications for Stopping Cocaine Dependence and Preventing Relapse
Cocaine Abuse · Cocaine-Related Disorders
Primary: Mean Percentage of Cocaine-positive Urines Over Course of 12 Week Treatment in Subgroup Achieving Abstinence at Baseline — 31; 28; 47; 35 Mean % of cocaine-positive urines
N/A N=106 Cocaine Withdrawal and Pharmacotherapy Response
Cocaine Dependence · Opiate Dependence
Primary: Percent Days Abstinent From Cocaine - Self Report — 72.9; 72.9; 59.3 percentage of days — p=.10
Phase 2 N=20 Prefrontal Cortex Stimulation as Treatment for Crack-cocaine Addiction
Cocaine Addiction · Cocaine-related Disorder · Executive Dysfunction
Primary: Abstinence — 71.4; 16.6 percentage of participants
N/A N=127 Cocaine Use Reduction and Health
Cocaine Use Disorder
Primary: Endothelin-1 Levels — 2.15; 2.063; 1.956 pg/ml
N/A N=112 Oxytocin in Cocaine Dependence
Cocaine Dependence
Primary: Subjective Stress Response TSST — 5.33; 5.28; 2.05; 2.13 units on a scale
Phase 2 N=118 Disulfiram for Cocaine Abuse
Cocaine Dependence
Primary: Cocaine Use Over Time — 0.01; 0.007; -0.01; 0.007 slope (change in prob of coc-pos utox/d) — p=<0.05
Phase 2 N=13 Modafinil for Smoked Cocaine Self-Administration
Cocaine Dependence
Primary: Cocaine Self-administration — 0; 0; 0; 2.2 Number of doses purchased
Early Phase 1 N=9 Impact of a Non-Drug Choice on Cocaine Reinforcement
Cocaine Dependence
Primary: The Number of Times Cocaine Was Selected in the Presence of a Monetary Reward Alternative — 2.75; 1.38; 1.38; 4.75 cocaine choices
Phase 2 N=81 A Placebo-Controlled Study of Mixed Amphetamine Salts and Topiramate for the Treatment of Cocaine Dependence
Cocaine Dependence
Primary: Three Weeks of Continuous Cocaine Abstinence as Measured by Urine Toxicology and Self Report Based on Time Line Follow Back — 13; 7 participants — p==.05
N/A N=31 Efficacy of Varenicline in Methadone-Stabilized Cocaine Users
Cocaine Dependence · Nicotine Dependence
Primary: Proportion of Cocaine Positive Urine Tests Per Week — .57; .58 Proportion of cocaine positive — p=0.84
Early Phase 1 N=18 Impact of Sustained Release d-Amphetamine on Choice Between Cocaine and a Non-Drug Reinforcer
Active Cocaine Users
Primary: The Number of Times Cocaine Was Selected in the Presence of a Monetary Reward Alternative — 0.06; 0.94; 0.75; 0.88 cocaine choices
Phase 2 N=81 Effectiveness of Memantine in Treating Cocaine-Dependent Individuals - 2
Cocaine-Related Disorders
Primary: Weekly Cocaine Use — 1.1; 1.3 days
Early Phase 1 N=12 Cocaine and Zolmitriptan
Cocaine Use Disorder
Primary: Reinforcing Effects of Cocaine — 1.4; 4; 4.5; 0.7 number of times subjects chose cocaine
Phase 2 N=171 Clinical Trial of Topiramate for Cocaine Addiction
Cocaine Dependence
Primary: Proportion of Cocaine Positive Urine Samples Per Treatment Condition — 45.4; 42.7; 53.5; 46.5 percentage of positive urine samples — p=0.531
Phase 3 N=127 Multicenter Trial of Combined Pharmacotherapy to Treat Cocaine Dependence
Cocaine Dependence
Primary: Three Weeks of Cocaine Abstinence at End of Study — 9; 0 Participants
Phase 2 N=20 Atomoxetine for Treating Cocaine Abuse in Adults With Attention Deficit Hyperactivity Disorder (ADHD)
Attention Deficit Disorder With Hyperactivity · Cocaine-Related Disorders
Primary: the Adult ADHD Rating Scale (AARS) (30% Reduction) — 50 percent of participants
Phase 2 N=15 Therapeutic Cocaine Vaccine: Human Laboratory Study
Cocaine Dependence
Primary: Cocaine Intoxication — 59; 51; 45; 44 units on a scale
Phase 2 N=23 Caffeine and Cocaine
Cocaine Dependence
Primary: Visual Analog Scale Subjective Rating of Drug Effects — 8.65; 9.85; 13.65; 10.43 units on a scale
N/A N=45 Neurocognitive Factors in Substance Use Treatment Response: The Ways of Rewarding Abstinence Project
Cocaine Use Disorder
Primary: % Cocaine-Negative Urine Specimens Per Participant — 42.2; 59.1; 51.0 % negative specimens per participant — p=0.177
Phase 3 N=207 Vigabatrin for the Treatment of Cocaine Dependency
Cocaine Addiction · Cocaine Dependence
Primary: Abstinence — 5; 9 participants
Phase 2 N=73 Effectiveness of Modafinil and D-amphetamine in Treating Cocaine Dependent Individuals
Cocaine-Related Disorders
Primary: Cocaine Use as Assessed by the Treatment Effectiveness Score (TES), Which is the Total Number of Cocaine-negative Urines During Treatment — 9.25; 6.09; 6; 4.91 number of…
Phase 2 N=210 Modafinil Treatment for Cocaine-Dependent Individuals
Cocaine-Related Disorders
Primary: Urine Toxicology for Cocaine — 3; 8; 3 Participants
Phase 2 N=55 Trial Of NS2359 For The Treatment of Cocaine Dependence
Cocaine Use Disorder
Primary: The Number of Participants Who Achieved Abstinence From Cocaine During the Last Three Weeks of the Trial — 2; 2 participants — p==0.97
Phase 2 N=8 Glutamatergic Modulation of Cocaine-related Deficits
Cocaine Dependence
Primary: Change in Cue Reactivity — 126; 18; 16 units on a scale (0-200), high is worse
N/A N=59 Cognitive Enhancement and Relapse Prevention in Cocaine Addiction
Cocaine Addiction
Primary: Drug Abstinence During Treatment and at Follow up Visits — 12; 25 percentage of drug abstinences
Phase 2 N=74 Pharmacogenetics of Disulfiram for Cocaine
Cocaine Dependence · Opioid Dependence
Primary: Urine Toxicology for Cocaine. — 84; 68; 56; 67 % cocaine + urines over 2 week blocks
Phase 1 N=30 Reinforcing Effects of Cocaine During Phendimetrazine Maintenance
Cocaine Use Disorder
Primary: Number of Times Cocaine Was Selected in the Presence of a Monetary Reward Alternative — .34; .24; 4.31; 3.9 Cocaine Choices
Phase 2 N=18 The Effect of Glutamatergic Modulation on Cocaine Self-administration
Cocaine Dependence
Primary: Number of Choices to Self-administer Cocaine (Out of 5 Choices) — 1.61; 4.33 number of cocaine choices