Clinical Trial Search

Primary: Mean Percentage of Cocaine-positive Urines Over Course of 12 Week Treatment in Subgroup Achieving Abstinence at Baseline — 31; 28; 47; 35 Mean % of cocaine-positive urines

Primary: Percent Days Abstinent From Cocaine - Self Report — 72.9; 72.9; 59.3 percentage of days — p=.10

Primary: Abstinence — 5; 9 participants

Primary: Cocaine Use Over Time — 0.01; 0.007; -0.01; 0.007 slope (change in prob of coc-pos utox/d) — p=<0.05

Primary: Subjective Stress Response TSST — 5.33; 5.28; 2.05; 2.13 units on a scale

Primary: Urine Toxicology Screens — 38.33; 41.85 percentage of cocaine negative urines — p=0.05

Primary: Functional Connectivity Between Corticolimbic Brain Regions During Acute Social Stress — .011; .012; .043; .0008 Arbitrary units

Primary: Number of Times Cocaine Was Selected in the Presence of a Monetary Reward Alternative — .34; .24; 4.31; 3.9 Cocaine Choices

Primary: Cocaine Self-administration — 0; 0; 0; 2.2 Number of doses purchased

Primary: Cocaine Self-administration — 2.5; 4.8 cocaine choices/participant

Primary: Endothelin-1 Levels — 2.15; 2.063; 1.956 pg/ml

Primary: Cocaine-positive Urine Results — 86.5; 92.4 percentage of BE urine tests

Primary: The Number of Participants Who Achieved Abstinence From Cocaine During the Last Three Weeks of the Trial — 2; 2 participants — p==0.97

Primary: The Number of Times Cocaine Was Selected in the Presence of a Monetary Reward Alternative — 2.75; 1.38; 1.38; 4.75 cocaine choices

Primary: Regional Availability of Metabotropic Glutamate Type-5 Receptors (mGluR5) — 36.48; 32.19; 25.67; 22.41 mL*cm^3 — p=0.035

Primary: Number of Times Cocaine Was Selected in the Presence of a Monetary Reward Alternative — 1.0; 0.1; 3.4; 3.9 Number of Cocaine Choices

Primary: Three Weeks of Continuous Cocaine Abstinence as Measured by Urine Toxicology and Self Report Based on Time Line Follow Back — 13; 7 participants — p==.05

Primary: Compulsion — 5.9; 5.5 score on a scale — p=<0.05

Primary: Proportion of Subjects in Each Treatment Group Abstinent During the Last 2 Weeks of Treatment. — 7; 5 participants

Primary: Cocaine Intoxication — 59; 51; 45; 44 units on a scale

Primary: Change in Visual Analog Questionnaire (VAQ) Score — 0.38; 3.75; 0.38; 40.63 units on a scale — p=<0.01

Primary: Attentional Bias as Assessed by Score on the Stroop Task — -13.90333; 27.118; -9.361269; 15.35407 milliseconds

Primary: The Number of Times Cocaine Was Selected in the Presence of a Monetary Reward Alternative — 0.06; 0.94; 0.75; 0.88 cocaine choices

Primary: Urine Toxicology for Cocaine — 3; 8; 3 Participants

Primary: Decision to Self-Administer Cocaine — 66; 66; 32; 32 percent of available doses

Primary: Cocaine Use as Assessed by the Treatment Effectiveness Score (TES), Which is the Total Number of Cocaine-negative Urines During Treatment — 9.25; 6.09; 6; 4.91 number of…

Primary: Number of Participants Who Are Cocaine Abstinent During the Last 2 Weeks of Treatment (Weeks 8-9), as Assessed by Urine Test — 0; 4; 2 Participants

Primary: Percentage of Participants With Presence of a Cocaine-Positive Urine Screen — 59.0; 49.2 percentage of participants

Primary: Confirmed Abstinence From Cocaine as Assessed by Treatment Effectiveness Score (TES) — 7; 9 cocaine-negative urines

Primary: Reinforcing Effects of Cocaine — 1.4; 4; 4.5; 0.7 number of times subjects chose cocaine