Phase 4 N=49 Compare Anti-inflammatory Dentifrices
Gingivitis
Primary: Gingival Index (GI) — 1.04; 1.01 units on a scale — p=<0.05
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 3 N=19 Investigation of Dental Plaque and Gingival Index
Dental Plaque
Primary: Gingival Margin Plaque Index — 15.4; 12.81 Units on a scale — p=0.05
N/A N=61 Trial of Toothpaste to Reduce Plaque and Inflammation
Plaque · Inflammation
Primary: Change in Oral Plaque — -1.05; -0.03 log(percentage) — p=0.001
N/A N=200 A Clinical Study to Evaluate Effects of an Oral Rinse on Plaque and Gingivitis
Plaque
Primary: Plaque Index Score Per Participant at 6 Months — 2.12; 2.70; 2.23; 2.84 score on a scale — p=<0.0001
Phase 3 N=120 Comparative Efficacy of a Toothpaste That Reduces Plaque and Gingivitis
Gingivitis
Primary: Gingivitis Index — 1.00; 1.27 Units on a scale — p=0.05
N/A N=30 The Effectiveness of Brushing and Flossing Sequence on Control of Plaque and Gingival Inflammation
Gingival Inflammation · Plaque · Gingival Bleeding
Primary: Change From Baseline in Mean BPI Index Scores at 2 Weeks — 0.396; -1.028 score on a scale — p=0.022
N/A N=90 A Comparative Study of Electric Toothbrushes for the Efficacy Plaque Removal and the Effect on Plaque Accumulation and Gingivitis.
Dental Plaque Induced Gingivitis · Dental Plaque
Primary: Plaque Index — 1.07; 1.19; 1.31; 1.11 units on a scale — p=0.1561
Phase 3 N=23 Clinical Study to Evaluate Dental Plaque
Gingival Diseases
Primary: Dental Plaque Index — 2.48; 2.42 Units on a scale — p=0.05
N/A N=32 Induced Gingivitis & Intra-oral Imaging
Plaque Induced Gingivitis
Primary: Change From Baseline Gingivitis at Day 14 as Measured by Non-invasive Microimaging and Gingival Index. — 0.6; 0.15 units on a scale
Phase 3 N=73 Clinical Research Study Efficacy of a Prototype Oral Rinse
Dental Plaque
Primary: Gingival Index — 1.90; 1.84 Units on a scale — p=0.005
Phase 2 N=27 Is an Antiplaque Chewing Gum (30 mg) Able to Reduce Dental Plaque in a Healthy Population?
Plaque Regrowth
Primary: Safety, Tolerability and Effectiveness in Reducing Dental Plaque of KLS-W Delivered in a Chewing Gum Formulation — 0; 0; 0; 0 participants
Phase 2 N=28 Evaluating Commercial Anti-Plaque Products and Oral Rinse
Dental Plaque
Primary: Plaque Index — 2.63; 2.65; 1.23 Units on a scale — p=0.05
Phase 3 N=32 Evaluate Dental Plaque Benefit of a Preventive Treatment Gel
Dental Plaque
Primary: Mean Turesky Modified Quigley-Hein Index at Day 4 — 1.83; 1.96 score on a scale
Phase 4 N=135 Six Month Plaque and Gingivitis Study Using Colgate Total Toothpaste
Dental Plaque · Gingivitis
Primary: Dental Plaque Score — 3.53; 3.55; 3.59 units on a scale — p=0.919
Phase 3 N=120 The Clinical Efficacy of Three Oral Hygiene Regimens Using a Manual Toothbrush, Toothpaste and a Mouthwash in Controlling Dental Plaque and Gingivitis
Dental Plaque · Gingivitis
Primary: Dental Plaque Scores — 3.33; 3.19; 3.31 units on a scale — p=0.434
Phase 2 N=23 Effect of a Commercial Cosmetic Mouth Rinse on Plaque Re-growth
Healthy Subjects
Primary: Plaque Index of Test Mouth Rinse Versus Sterile Water After Day 4 of Treatment Administration — 3.03; 3.23 Score on a scale — p=0.0915
Phase 2 N=162 The Clinical Investigation of a Zinc Based Toothpaste in Reducing Plaque and Gingivitis
Dental Plaque and Gingivitis
Primary: Gingivitis Scores — 1.48; 1.57; 1.49 units on a scale — p=0.091
Phase 3 N=103 Compare the Clinical Efficacy of Prototype Toothpastes.
Gingival Diseases
Primary: Dental Plaque — 2.273; 1.806; 2.041 Units on a scale — p=<0.05
Phase 3 N=29 Clinical Study to Compare Dental Plaque Control
Dental Plaque
Primary: Dental Plaque Index — 3.12; 2.90; 2.92; 2.94 Units on a scale — p=<0.05
Phase 2 N=71 Safety and Tolerability of Antiplaque Chewing Gum in a Gingivitis Population
Plaque · Gingivitis
Primary: Safety and Tolerability of KSL-W as Measured by Soft Tissue Erythema, Ulceration and Sloughing (AEs and SAEs) — 2; 1; 4; 2 Participants
Phase 4 N=49 Evaluate Inflammation Caused by Gingivitis in Adults
Gingivitis
Primary: Level of Gingival Crevicular Fluid Interleukin - 1 (GCF IL-1) at 2 Hours — 492.2; 326.3 Micrograms — p=0.05
Phase 4 N=69 Cetylpyridium Chloride (CPC) Based Chewing Gum and Gingivitis
Gingivitis · Plaque, Dental · Periodontal Diseases
Primary: Degree of Plaque as Assessed by the Turesky Modification of the Quigley-Hein Plaque Index — 0.41; 0.43 score on a scale
N/A N=50 Curved Soft-Picks on Plaque Accumulation on Patients With Gingivitis
Gingivitis
Primary: Change in Interproximal Plaque by Modification of the Quigley-Hein Plaque Index at 14 Days — 0.03; -0.07 score on a scale
Phase 3 N=102 Compare the Clinical Efficacy of Prototype Toothpastes
Dental Plaque
Primary: Plaque Index — 0.91; 0.84; 1.77 Units on a scale — p=0.05
Phase 4 N=179 Clinical Study Comparing Dental Plaque and Gingivitis Reduction After Using One of Three Oral Hygiene Multi-component Regimens (Using of a Manual Toothbrush, a Toothpaste and a Mouthwash)
Dental Plaque · Gingivitis
Primary: Dental Plaque Scores — 3.33; 3.22; 3.34 units on a scale — p=0.04
N/A N=56 Ability of Four Toothpastes to Remove Plaque
Dental Plaque
Primary: Mean Change From Baseline (Pre-brushing to Post-brushing) in Turesky Score After Single Supervised Use (Test Product 1 Versus [vs] Test Product 4) After 4 Weeks — 2.90…
N/A N=80 Efficacy of Manual Toothbrushes in Removing Dental Plaque
Dental Plaque · Oral Hygiene
Primary: Change From Pre to Post Brushing in Overall Mean Rustogi Modified Navy Plaque Index (RPI) After a Single Brushing Event at Day 0 — -0.09623; -0.12005; -0.09859; -0.09599…
N/A N=158 A Clinical Trial to Test the Effect of Marketed Mouth Rinses on Decreasing Plaque and Gum Inflammation
Plaque · Gingivitis
Primary: Whole Mouth Mean Modified Gingival Index (MGI) at Week 3 — 2.004; 1.770; 1.807 units on a scale — p=<0.001
N/A N=153 Study of an Experimental Toothbrush for Treatment and Prevention of Gingivitis
Dental Devices, Home Care
Primary: Whole-mouth Mean Modified Gingival Index (MGI) Score at Day 42 — 1.880; 1.770 Unit on a scale
N/A N=100 Efficacy of a Commercial Dentifrice Containing Ilex Rotunda Thunb Extract for Dental Plaque and Gingivitis
Gingivitis · Dental Plaque
Primary: Plaque Assessment After 6 Weeks of Dentifrice Use — 2.98; 3.04 units on a scale