N/A N=205 Depression Attention for Women Now (The DAWN Study)
Depressive Disorder
Primary: Depression Treatment Outcome — 0.96; 1.33 units on a scale
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 4 N=95 Stress and Inflammation in Late-Life Depression
Depression · Inflammation
Primary: IL-6 Levels — 5.25; 18.24; 3.69; 6.84 pg/mL — p=.44
Phase 2 N=133 Homeopathic Treatment for Depression in Peri- and Postmenopausal Women
Moderate Depression · Menopausal and Postmenopausal Disorders
Primary: Change From Baseline in 17-item Hamilton Rating Scale for Depression at 6 Weeks. — 9.9; 11.7; 15 Units in Hamilton Scale — p=<0.05
Phase 4 N=106 Aging Brain Changes, Executive Dysfunction and Depression
Depression
Primary: Hamilton Depression Rating Scale. — 8.09 units on a scale
N/A N=5 Venlafaxine for Depression in Alzheimer's Disease (DIADs-3)
Alzheimer's Disease · Depression
Primary: Changes in Dose Response Using the Modified Alzheimer's Disease (AD) Cooperative Study-Clinical Global Impression of Change. — 2; 0; 1; 2 Participants
N/A N=9 European Deep Brain Stimulation (DBS) Depression Study
Depressive Disorder, Major
Primary: Mean Percent Change From Baseline in MADRS Score — -7.7; -7.4; -8.8; -6.2 percentage change from baseline
Phase 4 N=30 Duloxetine Treatment in Elderly With Dysthymia
Depression · Dysthymic Disorder
Primary: Change in Hamilton Rating Scale for Depression (HAM-D, 24-item) From 0 Weeks to 12 Weeks. — 8 units on a scale — p=<0.001
Phase 3 N=131 Depression in Alzheimer's Disease-2
Alzheimer's Disease · Depression
Primary: Modfied Alzheimer's Disease Cooperative Study- Clinical Global Impression of Change (mADCS-CGIC) — 1; 0; 5; 2 participants — p=0.98
Phase 4 N=47 Vortioxetine for Menopausal Depression
Depression · Menopause · Vasomotor Disturbance
Primary: Change From Baseline in Montgomery-Asberg Depression Rating Scale Score (MADRS) at Week 8 (Visit 5) — -22.8 units on a scale
N/A N=94 Medication Treatment for Depression in Nursing Home Residents
Depression
Primary: Geriatric Depression Scale (GDS) Score — 5.11; 5.03; 4.59; 4.64 units on a scale
Phase 2 N=97 Assessing Symptomatic Clinical Episodes in Depression
Major Depressive Disorder
Primary: MADRS Score - Overall Change From Baseline — 13.7; 8.8 score on a scale — p=<.001
Phase 4 N=63 Raloxifene and Rimostil for Perimenopause-Related Depression
Perimenopausal Depression · Depression
Primary: Center for Epidemiologic Studies-Depression Scale (CES-D) — 27.4; 29.1; 28.8; 24.6 Units on a scale
Phase 4 N=61 Combination Treatment Study for Memory Impairment and Depression
Depression · Mild Cognitive Impairment
Primary: Selective Reminding Test (SRT) Total Recall — 45.6; 46.6 Words
Phase 3 N=35 Memantine Plus Es-citalopram in Elderly Depressed Patients With Cognitive Impairment
Mild Cognitive Impairment · Major Depressive Disorder · Alzheimer's Disease
Primary: Change in Selective Reminding Test - Total Immediate Recall (SRT-IR) — 7.5 units on a scale
Phase 4 N=59 Desvenlafaxine vs. Placebo Treatment of Chronic Depression
Dysthymic Disorder · Dysthymia · Chronic Depressive Disorder
Primary: Hamilton Rating Scale for Depression (HDRS24) — 14.63; 14.21 units on a scale — p=0.09
Phase 4 N=21 Brexpiprazole for Bipolar Depression
Bipolar Depression
Primary: The Montgomery-Asberg Depression Rating Scale (MADRS) — 31.95; 9.95; 10.95 score on a scale — p=<.001
Phase 4 N=15 Depressed Mood Improvement Through Nicotine Dosing (Depressed MIND Study)
Major Depressive Disorder
Primary: Change in Total MADRS (Montgomery Asberg Depression Rating Scale) Score — -18.45 units on a scale — p=<0.001
Phase 3 N=57 Lamotrigine for Symptoms of Geriatric Bipolar Depression
Bipolar Disorder · Depression, Bipolar
Primary: Assessment of Change in Depressive Symptoms From Baseline on the Montgomery Asberg Depression Rating Scale (MADRS) — -15.5 units on a scale — p=<.01
N/A N=1,206 Epidemiology of Depression, Anxiety, and Cognitive Impairment
Depression · Anxiety · Cognitive Impairment
Primary: Participants With Depression by Patient Health Questionnaire - 9 — 177 participants
Phase 3 N=54 Double-blind, Placebo-Controlled Divalproex Sodium ER in Bipolar I or Bipolar II Depression
Bipolar Disorder
Primary: Change in Montgomery-Asberg Depression Rating Scale (MADRS) Total Score — -9.64; -5.32 units on a scale
Phase 4 N=100 Antidepressant Response in the Treatment of Depressive Symptoms and Frailty Characteristics in Older Adults
Major Depressive Disorder · Dysthymic Disorder · Depressive Disorder, NOS
Primary: Hamilton Rating Scale for Depression (HRSD) — 13.3 score on a scale
N/A N=19 iTBS Study for Depression (Randomized)
Executive Dysfunction · Depression
Primary: Change in Montgomery-Asberg Depression Rating Scale (MADRS) Scores From Baseline to the End of the Intervention — 10.25; 13.33 score on a scale
Phase 4 N=22 Duloxetine for Menopausal Depression
Depression · Menopause · Vasomotor Symptoms
Primary: Change in Depression Scores as Measured by the Hamilton Rating Scale for Depression — -7.5 units on a scale
Phase 4 N=130 Antidepressant Medication Plus Donepezil for Treating Late-life Depression
Depression · Dementia
Primary: Global Cognitive Performance — -0.47; -0.47; -0.23; -0.65 Z-score
Phase 4 N=110 Antidepressant Treatment of Melancholia in Late Life
Depression · Melancholia
Primary: HAMILTON Rating Scale for DEPRESSION Range — 27.3; 27.1; 10.7; 8.4 units on a scale — p=<0.05
N/A N=80 Coping With Depression in Parkinson's Disease
Parkinson's Disease · Depression
Primary: Hamilton Depression Rating Scale: Baseline — 20.93; 19.38 units on a scale
Phase 3 N=598 Efficacy Study of Vortioxetine on Cognitive Dysfunction in Adult Patients With Major Depressive Disorder
Major Depressive Disorder
Primary: Change From Baseline to Week 8 in DSST (Number of Correct Symbols) and RAVLT (Acquisition and Delayed Recall) Using the Composite Z-score Defined as the Weighted Sum of…
N/A N=141 Treatment of Depressed Chronic Obstructive Pulmonary Disease Patients
Pulmonary Disease, Chronic Obstructive · Major Depression
Primary: Composite Antidepressant Score Scale (CAD) — 29; 25; 9; 20 Participants
N/A N=242 Combination Deplin® and Antidepressant Therapy for a Major Depressive Episode (MDE)- a Retrospective Analysis
Major Depressive Disorder
Primary: Improvement as Measured by Change in Clinical Global Impression of Severity (CGI-S) Rating From Baseline — 17; 10 Participants
Phase 4 N=16 Identifying and Treating Depression in Hemodialysis Patients
Depression · Hemodialysis-Induced Symptom
Primary: To Determine the Impact of Directly Observed Weekly Fluoxetine Treatment on Remission of Depression Among Hemodialysis Patients. — 6.6 units on a scale