N/A N=42 Mommy-Baby Treatment for Perinatal Depression
Depressive Disorder, Major · Postpartum Depression
Primary: Change in Edinburgh Depression Scale From Baseline — 17.81; 17.9; 12.04; 11.41 units on a scale
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=36 Neurophysiology of Postpartum Depression in an Experimental Model of Pregnancy and Parturition
Postpartum Depression
Primary: Blood-oxygen-level-dependent (BOLD) Response During Functional Magnetic Resonance Imaging (fMRI) z Statistic — 2.3; 2.0; 2.1; 1.7 z score — p=.27
N/A N=54 Behavioral Change in the Mother-Infant Dyad: Preventing Postpartum Depression
Postpartum Depression
Primary: Hamilton Rating Scales of Depression — 12.09; 17.17 units on a scale — p=.01
N/A N=175 PREPP: Preventing Postpartum Depression
Postpartum Depression (PPD)
Primary: Score on the Edinburgh Postnatal Depression Scale (EPDS) — 5.04; 4.36; 4.43; 4.04 score on a scale
Phase 4 N=5 Escitalopram (Lexapro) for the Treatment of Postpartum Depression
Postpartum Depression
Primary: Change in Clinician-rated Montgomery-Asberg Depression Rating Scale (MADRS) — -21.33 units on a scale
N/A N=99 Postpartum Wellness
Postpartum Depression
Primary: Depression Symptoms — 10.1; 11 score on a scale
Phase 2 N=162 Effectiveness of Sertraline Alone and Interpersonal Psychotherapy Alone in Treating Women With Postpartum Depression
Depression, Postpartum
Primary: Hamilton Depression Rating Scale (HAM-D) — 22.0; 21.8; 22.0; 8.8 units on a scale
N/A N=191 Responsive e-Health Intervention for Perinatal Depression in Healthcare Settings
Perinatal Depression
Primary: Change in Primary Health Questionnaire (PHQ-9) — 10.68; 10.24; 5.78; 7.48 score on a scale — p=.003
Phase 2 N=130 The Effect of Exercise on Preventing PostPartum Depression
PostPartum Depression
Primary: Structured Clinical Interview for DSM-IV Axis I Disorders — 7.94; 8.20 percentage of participants
N/A N=75 Social Media-Based Parenting Program for Women With Postpartum Depressive Symptoms
Postpartum Depression · Parenting · Parent-Child Relations
Primary: The Parent Child Early Relational Assessment (PCERA) — 3.0; 3.2; 3.3; 3.3 score on a scale
Phase 2 N=84 A Clinical Trial of Oral Ganaxolone in Women With Postpartum Depression
Depressive Disorder · Depression · Depression, Postpartum
Primary: Change From Baseline in Hamilton Depression Rating Scale 17-item Version (HAMD17) Through Treatment — -8.0; -5.7; -0.8; -2.6 score on a scale
N/A N=205 Depression Attention for Women Now (The DAWN Study)
Depressive Disorder
Primary: Depression Treatment Outcome — 0.96; 1.33 units on a scale
Phase 4 N=157 Timing of Postpartum Depot Medroxyprogesterone Acetate Administration on Breastfeeding, Contraceptive Continuation, and Depression
Contraception · Postpartum Depression · Lactation
Primary: Duration of Breastfeeding Among Women Who Plan to Breastfeed Their Infants After Postpartum or Delayed (4-6 Weeks Postpartum) Initiation of DMPA — 71; 70; 4; 4…
N/A N=40 Social Media Intervention for Postpartum Depression
Postpartum Depression · Parenting
Primary: Attendance — 83.3; 3.3 percentage of participants
Phase 2 N=15 The Role of Hormones in Postpartum Mood Disorders
Postpartum Depression
Primary: Edinburgh Postnatal Depression Scale (EPDS) Mean Total Score — 3.75; 3; 0; 1.14 Units on a scale
Phase 2 N=42 Preventing Postpartum Depression With Intranasal Oxytocin
Depression, Postpartum · Anxiety
Primary: Treatment Effect on Mother-infant Bonding — 99.33; 99.35; 101.11; 97.90 score on a scale — p=0.5
N/A N=120 Personalized Integrated Chronotherapy for Perinatal Depression
Depression · Postpartum Depression · Prenatal Disorder
Primary: Change in Depressive Symptoms — 1.6; 2.2 units on a scale
Phase 2 N=91 A Clinical Trial of Intravenous (IV) Ganaxolone in Women With Postpartum Depression
Depression · Depressive Disorder · Depression, Postpartum
Primary: Change From Baseline in Hamilton Depression Rating Scale 17-item Version (HAMD17) Total Score — -13.0; -12.0; -14.0; -14.3 Scores on a scale
Phase 2 N=21 A Study to Evaluate SAGE-547 in Participants With Severe Postpartum Depression
Severe Postpartum Depression
Primary: Change From Baseline at End of Treatment Period (at 60 Hours) in Hamilton Rating Scale for Depression (HAM-D) Total Score — -8.75; -20.97 score on a scale — p=0.008
N/A N=231 Improving Outcomes for Low-Income Mothers With Depression
Post Partum Depression
Primary: Depression Symptoms at 2 Months (QIDS SR-16 ≥ 11) — 32; 26 Participants
N/A N=29 Sleep-Disordered Breathing and PAP in Perinatal Depression
Sleep-disordered Breathing · Major Depressive Disorder
Primary: Change in Hamilton Rating Scale for Depression (HRSD) Score, Minus the Sleep Item — -7.62; -5.92; -8.21; -6.18 change in score — p=.367
Phase 3 N=126 Does Fish Oil Prevent Depression in Pregnancy and Postpartum?
Depression
Primary: Beck Depression Inventory — 7.9; 6.5; 6.3; 7.4 units on a scale — p=.29
Phase 2 N=4 Evaluate SAGE-547 in Female Participants With Severe Postpartum Depression
Postpartum Depression
Primary: Number of Participants With Treatment Emergent Adverse Events (TEAEs) and Treatment Emergent Serious Adverse Events (TESAEs) — 4; 0 Participants
N/A N=312 PRogram In Support of Moms: An Innovative Stepped-Care Approach for Obstetrics and Gynecology Clinics
Depression
Primary: Change in Edinburgh Postnatal Depression Scale Score (EPDS) — -4.3; -4.2 score on a scale
N/A N=10 The Effects of Light Therapy on Circadian Rhythms, Sleep, and Mood in Postpartum Depression
Depression, Postpartum
Primary: Change From Baseline Score of the Hamilton Depression Rating Scale-Seasonal Affective Version (SIGH-SAD) at 5 Weeks — 24.75; 12.88 SIGH-SAD score — p=.001
N/A N=46 Progesterone & Postpartum Relapse to Smoking
Tobacco Use Cessation · Tobacco Use Disorder
Primary: Number of Participants Who Relapsed by Week 4 Postpartum — 6; 7 participants
Phase 3 N=391 Maternal Depression Treatment in HIV
Depression
Primary: Rate of Maternal HIV Viral Suppression — 128; 132 Participants
Phase 3 N=200 A Study to Evaluate the Efficacy and Safety of SAGE-217 in Participants With Severe Postpartum Depression (PPD)
Depression, Postpartum
Primary: Change From Baseline (CFB) in the 17-item Hamilton Rating Scale for Depression (HAM-D) Total Score at Day 15 — 28.8; 28.6; -11.4; -15.6 score on a scale — p=0.0007
N/A N=500 Preventing Depressive Relapse in Pregnant Women With Recurrent Depression
Depression · Pregnancy Related · Antenatal Depression
Primary: Number of Participants Experiencing Relapse of Depression — 81; 111 Participants
Phase 4 N=80 A Pilot Trial of Perinatal Depression Treatment in HIV Infected Women
Perinatal Depression · HIV-1-infection
Primary: Number of Women Approached Who Agreed to Pre-Screening With EPDS — 240 Participants