N/A N=287 Dual Diagnosis Self-Help Referral
Dual Diagnosis
Primary: Psychiatric Functioning at 6 Months — .333; .387 units on a scale
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 2 N=406 Dual Diagnosis Inpatients: Telephone Monitoring RCT to Improve Outcomes
Diagnosis, Dual (Psychiatry)
Primary: Readiness to Attend Substance Use Disorder Continuing Care — 1.8; 2.2 units on a scale — p=<.05
N/A N=102 A Brief Community Linkage Intervention for Dually Diagnosed Individuals
Schizophrenia · Psychotic Disorders · Substance-Related Disorders
Primary: Treatment Engagement — 4.2; 1.4; 7.2; 1.5 number of treatment sessions attended — p=<0.001
N/A N=81 Integrated Treatment of OEF/OIF Veterans With PTSD & Substance Use Disorders
Posttraumatic Stress Disorders · Combat Disorders · Alcohol Dependence
Primary: Change in Post-traumatic Stress Disorder Symptomatology — -51.2; -35.9; -22.3; -10.9 score on a scale
Phase 2 N=119 Integrated Alcohol Disorder and PTSD Treatment
PTSD · Alcoholism
Primary: Clinician Administered PTSD Scale (CAPS) — 43.2; 42.1; 25.8; 32.9 score on a scale — p=.002
Phase 4 N=49 Serotonin Selective Reuptake Inhibitor Treatment of Dual Diagnosis Post-traumatic Stress Disorder and Alcohol Problems
PTSD · Alcohol Use Disorder
Primary: Percent Heavy Drinking Days — 55.5; 65.1 percentage of days
N/A N=183 Integrated vs Sequential Treatment for PTSD and Addiction
PTSD · Substance Addiction
Primary: PTSD Symptoms — 55.5; 54.1 units on a scale
Phase 4 N=96 Clinical Medication Development for Bipolar Disorder and Alcohol Use Disorders
Alcohol Use Disorder · Bipolar Disorder · Schizoaffective Disorder Bipolar Type
Primary: Baseline-to-Exit Change in Drinks Per Drinking Day (TLFB) — -1.98; -2.82; -1.22 Standard Drinks per Drinking Day
N/A N=79 Integrated Care for Patients With High Risk Substance Use and Psychiatric Disorder With Chronic Direct Acting Antiviral Treatment
Hepatitis C · Depression · PTSD
Primary: Sustained Viral Response (SVR) — 30; 12.8 percentage of Participants — p=0.07
Phase 3 N=31 Lithium and Divalproex for the Treatment of Comorbid Rapid Cycling Bipolar Disorder and Substance Abuse Disorder
Bipolar Disorder
Primary: Time to Treatment for Emerging Symptoms of a Mood Relapse — 17.8; 15.9 weeks
N/A N=47 HealthCall-S: A Pilot Study Targeting Concurrent Non-injection Drug Use and Alcohol in HIV Primary Care Clinics
Alcohol or Other Drugs Use
Primary: Mean Number of Days Used Primary Drug (NumDU) — 8.5; 5.0 days
N/A N=60 A Pilot Study of Citicoline add-on Therapy in Patients With Bipolar Disorder or Major Depressive Disorder and Amphetamine Abuse or Dependence
Amphetamine Abuse · Amphetamine Dependence · Bipolar Disorder
Primary: Depression Symptoms — 26.2; 33.1 scores on a scale — p=0.05
N/A N=18 Atomoxetine/Attention Deficit/ Hyperactive Disorder (ADHD)/Substance Use Disorder (SUD)in a Residential Treatment Facility
Attention Deficit Hyperactivity Disorder
Primary: Change in Adult ADHD Investigator Symptom Rating Scale Score — 17.3 units on a scale
Phase 4 N=41 Disulfiram Combined With Lorazepam for Alcohol Dependence and Anxiety Disorder
Alcohol Dependence · Anxiety Disorder
Primary: Treatment Adherence — 15 Participants
Phase 3 N=500 Adaptive Treatment for Alcohol and Cocaine Dependence
Substance Use Disorders
Primary: Treatment Engagement — 3.92; 3.50 treatment days — p=0.11
Phase 2 N=69 Combined Treatment for Alcohol-Dependent Individuals With PTSD
Stress Disorders, Post-Traumatic · Alcohol Abuse · Substance-Related Disorders
Primary: Heavy Drinking Days/Week — 3.13; 2.89; 1.05; 0.48 Days/Week — p=0.34
N/A N=180 Impact of Group Motivational Interviewing and In-Home-Messaging-Devices for Dually Diagnosed Veterans
Alcohol Dependence · Dual Diagnosis · Drug Dependence
Primary: Number of Alcohol Drinking Days in the Previous 30 (One Month Follow up) and 60 (Three Month Follow up) Days — 5.1; 6.5; 6.7; 8.8 Days Using Alcohol — p=<0.01
N/A N=674 STAR*D Alcohol: Treatment of Depression Concurrent With Alcohol Abuse
Major Depressive Disorder · Alcohol Use Disorder
Primary: Quick Inventory of Depression- Self Report 16 — 9.3; 8.9 units on a scale
N/A N=98 Screening, Brief Intervention, and Referral to Treatment in Primary Care
Diabetes Mellitus, Type 2 · Substance-related Disorders
Primary: Drug Use Status and Frequency — 2.00; 0.03; 0.02; 0.60 units on a scale
N/A N=97 Specialized Community Disease Management to Reduce Substance Use and Hospital Readmissions
Drug Use · Alcohol Use · Congestive Heart Failure
Primary: Change in Substance Use Rates From Baseline — 51.37; 51.38; 35.53; 26.65 Days of Substance Use
N/A N=105 Neurobiology of Alcohol and Nicotine Co-Addiction
Alcohol Use Disorder · Nicotine Use Disorder
Primary: Brain Activation During Functional Magnetic Resonance Imaging (fMRI) in Response to a Stress Modulated Cue Induced Craving Task (DSNBACK) — -26.1562; -45.2123; 18.4989…
N/A N=89 Skills Based Counseling for Adherence and Depression in HIV+ Methadone Patients - 1
Adherence · Depression · Heroin Dependence
Primary: Percent Medication Adherence at 3-month Follow-up Assessment — 79.02; 73.66 percent (doses taken/doses prescribed) — p=<.05
Phase 4 N=130 Citicoline for Bipolar 1 Disorder and Cocaine Dependence
Bipolar Disorder · Cocaine Dependence
Primary: Percentage of Participants With Presence of a Cocaine-Positive Urine Screen — 59.0; 49.2 percentage of participants
N/A N=254 Collaborating to Heal Addiction and Mental Health in Primary Care
Opioid-use Disorder · Mental Health Disorder
Primary: Opioid Use Other Than As Prescribed — 3.92; 0.72 Days — p=<0.001
Phase 4 N=20 Treatment of Nicotine Dependence and Acute Depression
Major Depressive Disorder · Nicotine Dependence
Primary: Hamilton Depression Scale Score — -.5322 percentage of change in depression — p=<.001
Phase 3 N=141 Treating Violence-Prone Substance Use Disorder Patients
Substance-related Disorders · Violence
Primary: Addiction Severity Index Legal Composite — .038; .012 units on a scale
Phase 2 N=118 Disulfiram for Cocaine Abuse
Cocaine Dependence
Primary: Cocaine Use Over Time — 0.01; 0.007; -0.01; 0.007 slope (change in prob of coc-pos utox/d) — p=<0.05
N/A N=200 Improving Outcomes for Individuals With Serious Mental Illness and Diabetes
Diabetes Mellitus · Bipolar Disorder · Depression
Primary: Brief Psychiatric Rating Scale (BPRS) at 60 Weeks — 32.04; 35.89 scores on a scale — p=.785
N/A N=5,706 Computerized Substance Use and Depression Screening and Behavioral Treatment in HIV Primary Care
Substance Use Disorders · HIV · Depression
Primary: Change in Mental Health and Substance Use Screening Rates — 2008; 2379 Participants
N/A N=200 Women's Treatment and Early Recovery
Substance-related Disorders
Primary: Treatment Completion — 43; 31 Number of women — p=<0.05