N/A
N=5,706
Computerized Substance Use and Depression Screening and Behavioral Treatment in HIV Primary Care
Substance Use Disorders · HIV · Depression · Anxiety
Bottom Line
View on ClinicalTrials.gov: NCT03217058 ↗Enrolled (actual)
5,706
Serious AEs
0.0%
Results posted
Oct 2025
Primary outcome: Primary: Change in Mental Health and Substance Use Screening Rates — 2008; 2379 Participants
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Clinic-based screening and behavioral interventions (Behavioral)
- Age
- Pediatric, Adult, Older Adult
- Sex
- All
- Sponsor
- University of California, San Francisco
- Primary completion
- Jul 2020
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Change in Mental Health and Substance Use Screening Rates |
2008; 2379 | — |
| PRIMARY Treatment Rate |
1079; 249; 226; 962; 228; 191 | — |
| PRIMARY Treatment Rate |
1079; 249; 226; 962; 228; 191 | — |
| SECONDARY Change in Substance Use Severity: Tobacco, Alcohol, Prescription Medication, and Other Substance Use Tool (TAPS) |
-0.36; -0.72; -0.61 | — |
| SECONDARY Change in Patient Health Questionnaire-9 (PHQ-9) and Generalized Anxiety Disorder 2-item (GAD-2) Scores |
-5.25; -1.42 | — |
| SECONDARY HIV Viral Control Change and Substance Use |
867; 164; 551 | — |
| SECONDARY HIV Viral Control Change and Mental Health |
990; 240; 253 | — |
Summary
Substance use disorders (SUDs), depression and anxiety in HIV-infected patients result in poor HIV outcomes, yet are often unrecognized and untreated. To address these problems, this study examines the implementation and effectiveness of a clinical intervention consisting of self-administered tablet-based SUD and depression screening at routine HIV primary care clinic visits, followed by evidence-based treatments for SUD, anxiety and depression delivered by a behavioral health specialist. If successful, this study has potential to reduce SUD-, anxiety- and depression-related problems and reduce HIV treatment disparities for patients with these comorbidities.
Eligibility Criteria
Inclusion Criteria
- HIV-positive adults
Exclusion Criteria
- Patients under age 18
Data sourced from ClinicalTrials.gov (NCT03217058). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.