N/A Completed N=5,706 Health Services Research

Computerized Substance Use and Depression Screening and Behavioral Treatment in HIV Primary Care

Substance Use Disorder · HIV · Depression · Anxiety

Source: ClinicalTrials.gov NCT03217058 ↗

Enrolled (actual)

5,706

Serious AEs

0.0%

Results posted

Oct 2025

Primary outcomePrimary: Change in Mental Health and Substance Use Screening Rates — 2008; 2379 Participants

Summary

Substance use disorders (SUDs), depression and anxiety in HIV-infected patients result in poor HIV outcomes, yet are often unrecognized and untreated. To address these problems, this study examines the implementation and effectiveness of a clinical intervention consisting of self-administered tablet-based SUD and depression screening at routine HIV primary care clinic visits, followed by evidence-based treatments for SUD, anxiety and depression delivered by a behavioral health specialist. If successful, this study has potential to reduce SUD-, anxiety- and depression-related problems and reduce HIV treatment disparities for patients with these comorbidities.

Outcome Measures

Outcome	Result	p-value
PRIMARY Change in Mental Health and Substance Use Screening Rates	2008; 2379	—
PRIMARY Treatment Rate	1079; 249; 226; 962; 228; 191	—
SECONDARY Change in Substance Use Severity: Tobacco, Alcohol, Prescription Medication, and Other Substance Use Tool (TAPS)	-0.36; -0.72; -0.61	—
SECONDARY Change in Patient Health Questionnaire-9 (PHQ-9) and Generalized Anxiety Disorder 2-item (GAD-2) Scores	-5.25; -1.42	—
SECONDARY HIV Viral Control Change and Substance Use	867; 164; 551	—
SECONDARY HIV Viral Control Change and Mental Health	990; 240; 253	—

Eligibility Criteria

Inclusion Criteria

HIV-positive adults

Exclusion Criteria

Patients under age 18

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT03217058). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.