N/A N=84 A Clinical Trial of Silver Diamine Fluoride to Arrest Early Childhood Caries in Young Children
Early Childhood Caries
Primary: Overall Arrest Rates — 81.3; 61.5; 78.1; 95.8 percentage of lesions arrested
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 3 N=2,060 Preventing Caries in Preschoolers: Testing a Unique Service Delivery Model in American Indian Head Start Programs
Fluoride Varnish and Oral Health Promotion · Usual Care
Primary: Evaluation of Decayed, Missing, and Filled Tooth Surfaces (Dmfs) at Baseline — 19.9; 22.8 dmfs
N/A N=580 Family-centered Oral Health Promotion for New Parents
Dental Caries
Primary: Early Childhood Caries (ECC) — 8; 41 Participants
Phase 3 N=983 Prevention of Adult Caries Study (PACS)
Caries, Dental
Primary: Total Net D12FS Caries Increment (Total of Non-cavitated Lesions (D1), Cavitated Lesions (D2) and Sound Surfaces (S)) — 2.43; 2.68 weighted increment units/13 months…
N/A N=2,108 Providers Against Cavities in Children's Teeth
Dental Caries
Primary: Dental Attendance — 330; 332; 170; 150 Participants
Phase 2 N=597 Glass Ionomer Sealant and Fluoride Varnish Study to Prevent Early Childhood Caries
Dental Caries
Primary: Caries Incidence — 137; 123 Participants
N/A N=7,418 Comparative Effectiveness of School-based Caries Prevention
Dental Caries · Quality of Life
Primary: Proportion of Subjects With All Caries Arrested — 108; 101 Participants
N/A N=3,345 Comparative Effectiveness of Treatments to Prevent Dental Caries
Dental Caries
Primary: Number of Participants With Arrested Dental Caries, Assessed Using a Clinical Oral Examination — 48; 53 Participants
Phase 3 N=376 Fluoride Varnish Randomized Clinical Trial
Dental Caries
Primary: Number of Caries Incident Cases — 42; 23; 14 participants — p=<0.001
N/A N=754 Interactive Parent-Targeted Text Messaging in Pediatric Clinics to Reduce Caries Among Urban Children
Caries, Dental · Health Behavior
Primary: Dental Caries Increment — 162; 161 Participants
Phase 2 N=296 Effect of CPP-ACP Paste on Dental Caries in Primary Teeth
Dental Caries
Primary: the Mean Number of Enamel Carious Lesion — 13.69; 14.55 Surfaces
N/A N=488 BEhavioral EConomics for Oral Health iNnovation Trial
Toothbrushing · Dental Plaque · Parent-Child Relations
Primary: Toothbrushing Performance — 4.6; 5.6 qualifying half-day episodes per week
N/A N=12 Dental Office Prevention Strategies for Children
Dental Plaque
Primary: Dental Plaque Levels Measures on Scale of 0-2 — 0.391 units on a scale
N/A N=169 European Study on Three Different Approaches to Managing Class 2 Cavities in Primary Teeth
Dental Caries
Primary: Failure Rate of the Three Treatment Arms Judged Clinically — 37; 31; 39; 2 Teeth — p=0.02
N/A N=525 Xylitol for Caries Prevention in Inner-City Children
Dental Caries
Primary: Change in the Number of Decayed or Filled Permanent Teeth (DFT) From Baseline (Beginning of Kindergarten) to the Middle of 2nd Grade — 0.38; 0.48 Number of surfaces…
Phase 2 N=70 Self Assembling Peptide P11-4 in Patients With Early Occlusal Carious Lesions
Dental Caries
Primary: Caries Activity and Progression Assessment Using LASER Fluorescence Readings by Diagnodent® Device. — 18.6; 1.1 units on a scale
N/A N=51 Treatment of Interproximal Cavities on Primary Molar Teeth With Silver Diamine Fluoride
Dental Caries in Children · Dental Caries Class II · Dental Caries
Primary: Interproximal Caries Zone of Radiolucency — 9; 7; 10; 12 Number of teeth
Phase 3 N=55 A Clinical Study to Evaluate Experimental Children's Toothpastes in an In-Situ Caries Model
Dental Caries
Primary: Percentage Surface Microhardness Recovery of Test Dentifrices Relative to Placebo Dentifrice — 30.72; 29.49; 28.29; 25.13 %SMHR — p=<0.0001
N/A N=57 Silver Diamine Fluoride and Papain-Based Gel for Management of MIH-affected Molar in Paediatric Patients
Molar Incisor Hypomineralization · Dental Caries · Hypomineralization of Enamel
Primary: Clinical Outcome Based on Success After Intervention on MIH Affected Molar at 6 Months — 17; 18; 17 number of Successful MIH affected molars
Phase 2 N=274 Efficacy and Safety Evaluation of Anti-Caries Varnish
Dental Caries in Children
Primary: Caries Increment — 9.8; 11.3 Number of tooth surfaces — p=0.279
Phase 4 N=40 MI Varnish and MI Paste Plus in a Caries Prevention and Remineralization Study
Dental White Spots · Dental Caries
Primary: Change in White Spot Lesions Count - Enamel Decalcification Index (EDI) — 40.2; 41.3 units on a scale
Phase 3 N=98 Effectiveness of Silver Diamine Fluoride as a Treatment for Caries in Comparison to Traditional Restorative Techniques
Caries
Primary: Caries Arrest of Teeth in the SDF Group Measured by Change in Size — 10 Participants
N/A N=17 Radiographic Progression of Infiltrated Caries Lesions In-vivo
Dental Caries
Primary: Number of Lesions Showing Radiographic Progression as Measured by Lesion Size (Continuous) — 2; 11 Lesions — p=0.002
Phase 3 N=65 In Situ Caries Model of Fluoride Toothpastes
Caries
Primary: Percent Surface Microhardness (SMH) Recovery of Enamel Specimens Exposed to NaF Toothpaste (1426ppmF) and AmF Toothpaste (1400ppmF) — 38.05; 41.06 Percentage SMHR…
Phase 3 N=60 Anticaries Effect of Xylitol,Probiotic and Chlorhexidine Mouth Rinses Among Individuals at High Risk
Cariostatic Agents · Mouthwashes
Primary: Change in Streptococcus Mutans Levels in Dental Plaque — 3.11; 0.93; 1.91; 2.23 log10CFU/g — p=0.123
Phase 3 N=394 Healozone Study to Evaluate the Safety and Efficacy of the Use of Ozone for Management of Dental Caries
Dental Caries
Primary: ICDAS Severity Value — 17; 22; 278; 273 teeth — p=0.1126
Phase 2 N=345 Non-invasive Treatment of Root Caries in Older Adults
Root Caries
Primary: Root Caries Activity — 3.72; 40.52 Percentage of active lesions (2-years)
N/A N=420 Coordinated Oral Health Promotion (CO-OP) Chicago
Dental Caries in Children · Health Behavior · Healthcare Disparities
Primary: Parent-reported Tooth Brushing Frequency — 1; 1; 12; 15 Participants
N/A N=1,136 Addressing Obesity in Early Care and Education Settings
Obesity
Primary: Child BMI Z-score — 0.40; 0.43; 0.31; 0.48 Z-score — p=0.003
Phase 3 N=323 Preventing and Arresting Dental Root Surface Caries in Community-dwelling Older Adults
Dental Caries
Primary: Number of New Tooth Root Caries Lesions — 1.1; 0.43; 0.56 new carious root surfaces