N/A N=88 Prolonged Daily Fasting as a Viable Alternative to Caloric Restriction in At-Risk Obese Humans
Obesity
Primary: Change in Weight — -3; -3.5; -1.3 Kg
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 3 N=164 Calorie Restriction and Changes in Body Composition, Disease, Function, and Quality of Life in Older Adults
Obesity · Diabetes · Hypertension
Primary: Change in Abdominal Fat Mass — -192.6; -21.9; -275 Cubic cm
N/A N=38 Caloric Restriction in Treating Patients With Stage 0-I Breast Cancer Undergoing Surgery and Radiation Therapy
Ductal Breast Carcinoma in Situ · Invasive Ductal Breast Carcinoma · Invasive Lobular Breast Carcinoma
Primary: Number of Participants Who Are Adherent to the Diet Restriction — 28 participants
N/A N=15 Effect of Caloric Restriction and Protein Intake on Metabolism and Anabolic Sensitivity
Weight Loss · Starvation
Primary: Change in Resting Metabolic Rate — -63.4; -77.6; -47.4 kcal change
N/A N=100 Alternate Day Fasting for Weight Loss, Weight Maintenance and Cardio-protection
Coronary Heart Disease · Obesity · Weight Loss
Primary: Body Weight — -4.6; -4.5; 0.3 Percent change at month 12
N/A N=6 Time Restricted Eating Pilot - Bariatrics
Time Restricted Feeding
Primary: Weight — -.07 kg
N/A N=64 TRE in Type 2 Diabetes (See Food Study 3)
Type2Diabetes
Primary: Change in Glycemic Measures- HbA1c (12w) — -0.22; -0.25 percentage of glycated hemoglobin
N/A N=30 Low-calorie Diet and Body Composition Prior to Roux-en-Y Gastric Bypass
Morbid Obesity · Liver Fat
Primary: Change in Intra-hepatocellular Lipid Content (IHCL) Following the Pre-operative Diet — 40.0; 67.4; 0.1 percentage of change in IHCL
Phase 4 N=60 The Effects of Formula Diet on Body Weight, Body Composition, and Biomarkers for Disease Compared to a Standard Diet
Body Weight Changes
Primary: Body Weight Loss (kg and Percent) at Months 3 and 6
N/A N=29 Time Restricted Eating on Cancer Risk
Pre-diabetes · Breast Cancer · Time Restricted Feeding
Primary: Change in Advanced Glycation End Products (AGE) as Assessed by Plasma — 5.82; 6.38; 5.82; 6.40 ng/mL
N/A N=33 Time Restricted Eating for Metabolic and Psychological Optimization
Mild Cognitive Impairment · Obesity
Primary: Change in Memory Composite Rank — 6.22 rank — p=<0.001
N/A N=71 Long-term Caloric Restriction and Cellular Aging Markers
Aging
Primary: Telomere Length — 0.96; 1.06; 1.06; 1.22 ratio
N/A N=33 Young Adult Eating Habits
Eating Behavior · Eating Habit
Primary: Change in Brain Response From Baseline to 2-weeks Post High UPF or 2 Weeks no UPF Diet — 0.02; 0.13 arbitrary units
N/A N=126 Weight Loss With Meal-Replacement Therapy in Teens
Obesity, Severe · Pediatric Obesity
Primary: Body Mass Index (From Baseline to 1-year) — -0.9; -6.6 Percent change in BMI
N/A N=28 Daily Caloric Restriction and Intermittent Fasting in Overweight and Obese Adults With Autosomal Dominant Polycystic Kidney Disease
Polycystic Kidney, Autosomal Dominant
Primary: Feasibility to Enroll and Retain Participants — 122 Participants
N/A N=29 Neuroimaging of Diet in ADHD: Phase I
Attention Deficit Disorder With Hyperactivity
Primary: ADHD Rating Scale IV — 18.0; 21.3 units on a scale
N/A N=50 Time Limited Eating in Adolescents (Time LEAd): a Pilot Study
Obesity, Childhood
Primary: Percent Change in BMI in Excess of the 95th Percentile (%BMIp95) — -3.27; -3.76; -4.85 percent — p=0.4
N/A N=60 Effect of Intermittent Calorie Restriction on MASLD Patients With Abnormal Glucose Metabolism
Fatty Liver Disease · Type 2 Diabetes · Impaired Glucose Regulation
Primary: Change of Liver Fat Content in % — -20.5; -15.5; -7.6; -7.3 absolute fat content change in %
Early Phase 1 N=13 Dopamine Receptor Contributions to Prediction Error and Reversal Learning in Anorexia Nervosa
Anorexia Nervosa
Primary: Measurement of Brain Activation (Measured in Percent Signal Change) During a Prediction Error Taste Reward Task Using Functional Magnetic Resonance Imaging (fMRI)…
N/A N=96 Effect of High Protein Weight Loss for Seniors
Obesity · Weight Loss
Primary: Change in 400 Meter Gait Walk Speed — 0.01; -0.02 meters/second
N/A N=50 Calorie-restricted, Ketogenic Diet and Transient Fasting During Reirradiation for Patients With Recurrent Glioblastoma
Recurrent Glioblastoma
Primary: Progression-free-survival — 20; 16 percentage of participants
N/A N=81 Pilot Study of Time Restricted Feeding as a Weight Loss Intervention
Obesity
Primary: Changes in Body Weight — -5.1; -6.2 kg
Phase 2 N=43 Reduced Carbohydrate Versus Fat in Obese Subjects
Obesity
Primary: Change in Respiratory Quotient (RQ) — -0.0552; 0.00453 ratio
N/A N=39 The Effect of Protein-enriched Diet on Body Composition and Appetite
Overweight · Obese · Metabolic Syndrome
Primary: Change in Lipid Content of the Liver (Intrahepatocellular Lipid) — 27.9; 9.3; 21.4; 5.9 % IHCL — p=<0.05
N/A N=218 CALERIE: Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy
Aging
Primary: Change in Core Body Temperature, Baseline to 12 Months — -0.05; -0.03 degrees Celsius — p=0.70
N/A N=201 Study of Nutrition and Activity in Kids
Obesity, Adolescent · Adolescent Behavior
Primary: zBMI Change — 0.433; 0.55; 0.376; 0.61 z-score
N/A N=12 Inflammation and Protein Restriction
Protein Restriction · Diet · Inflammation
Primary: Changes in the Human Intestinal Microbiome That Result From Short Term Dietary Adjustment. — 232; 172; 145; 93 Number of immunity related genes — p=0.05
N/A N=60 Dietary Carbohydrate Manipulation and Energy Balance: RCT
Physical Activity · Diet Modification
Primary: Physical Activity Energy Expenditure (kJ/Day or kcal/Day) — 1229; 1096; 1275; 1142 kcal/d
N/A N=46 Intermittent Calorie Restriction, Insulin Resistance, and Biomarkers of Brain Function
Alzheimer's Disease · Obesity · Diabetes Mellitus
Primary: Mean Change in Neuron-Derived Extracellular Vesicle (NDEV) Phosphorylated Serine312-insulin Receptor Substrate-1 (pS312-IRS-1) — 79.01; 443.72; -337.70; -608.92 pg/mL
N/A N=21 Effects of Low Fat Versus Low Carbohydrate Diets on Energy Metabolism
Healthy · Healthy Volunteers
Primary: Ad Libitum Energy Intake — 2752; 2063 kcal per day