Phase 4 N=8 Impact of Erythropoietin on Hematological Adaptations and Physical Performance
Exercise-Induced Anemia · Physical Performance
Primary: Concentration of Hemoglobin — 1.46 g/dL
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Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 2 N=32 Exercise Intolerance in Renal Failure
Kidney Failure, Chronic
Primary: Change in Resting Muscle Sympathetic Nerve Activity (MSNA) — -7.5; 3.2 bursts/minute
N/A N=94 Gas Exchange Kinetics and Work Load During Exercise
Methods of Exercise in Children
Primary: Maximum Oxygen Uptake (VO2) Measurements During Exercise — 1.6; 2.8; 3.2; 1.7 L/min
N/A N=45 Echinacea-based Supplement Does Not Improve Markers of Performance in Athletes
Ineffective Erythropoiesis
Primary: VO2 Max — 55.1; 56.7 ml/kg/min
Phase 2 N=12 Evaluation of the Attenuation by Aes-103 of Hypoxia Mediated Decrements in Endurance Exercise Performance
Hypoxia
Primary: Primary Objective Endurance Exercise Performance — 22.4; 24.5; 24.0; 24.6 minutes
N/A N=12 Effect of Exercise in OI
Orthostatic Intolerance · Postural Tachycardia Syndrome
Primary: Maximal Oxygen Consumption Capacity (VO2 Max) — 27.6; 24.5 mL/kg/min
N/A N=75 Understanding the Exercise-Hypertension Paradox
Hypertension
Primary: Blood Pressure — 103; 106; 94; 101 mmHg
N/A N=135 Effects of Exercise in Combination With Epoetin Alfa
Multiple Myeloma
Primary: Number of Red Blood Cell Transfusions Needed to Maintain Hemoglobin Levels (Short Term) — 2.3; 1.8 RBC Transfusions — p=<0.025
Phase 2 N=41 Rapid Acclimatization to Hypoxia at Altitude
Physiological Function in Low Oxygen Environment
Primary: Magnitude of Decrement in Exercise Time Trial Performance in Hypoxia (Low Oxygen) Compared With Normoxia (Normal Oxygen). — 22.3; 25.2; 22.2; 24.0 minutes
N/A N=20 Sex Differences in Vascular Responses to Exercise
Aging
Primary: Change in FMD in Response to Chronic HIIT — 0.11; 0.57; 0.81; 0.10 % flow mediated dilation
N/A N=10 Beetroot Juice as a Potential Ergogenic Aid During Exercise in Hypoxia
Hypoxia
Primary: Time to Complete a 10 km Run — 2862; 2874 Seconds
Phase 4 N=154 Clinical Evaluation of Iron Treatment Efficiency Among Non-anemic But Iron-deficient Female Blood Donors
Fatigue · Iron Deficiency
Primary: Level of Fatigue Before and After Iron Treatment/Placebo, Using a 10 Point Visual Analogue Scale. — 3.4; 3.5 centimeter — p=0.69
N/A N=28 Exercise, Oxidative Stress and HIV
HIV Infections
Primary: Total Glutathione — 1,964; 3,490; 1,865; 3,995 nmoles glutathione/ ml of sample — p=<0.05
Phase 2 N=56 Anemia in Heart Failure With a Preserved Ejection Fraction (HFPEF)
Anemia
Primary: Change in Left Ventricular End-diastolic Volume — -6; -4 mL
Phase 4 N=42 VO2 Max: In Vivo Model for Functional Red Cell Testing. Can RECESS be Explained?
Healthy
Primary: Percent Change From Baseline in Maximal Oxygen Uptake (VO2 Max) After Blood Cell Transfusion — 10.5; 8.5; 10.9 percent change
Phase 4 N=8 Effects of Pioglitazone on Exogenous Carbohydrate Oxidation During Steady-State Exercise at High Altitude
High Altitude
Primary: Rate of Exogenous Glucose Oxidation — 0.31; 0.32 g/min
Phase 2 N=31 Red Blood Cell ATP Release and Vascular Function in Humans
Cardiovascular Diseases
Primary: Forearm Blood Flow Responses to Hypoxia After Administration of Intervention — 6.3; 6.2; 2.1; 8.4 mL/min — p=0.97
N/A N=9 Exercise Mode and Acute Bone Resorption
Osteoporosis · Aging
Primary: C-telopeptide of Type I Collagen (CTX) Change — 0.09; 0.08 ng/mL
N/A N=10 High Altitude and Exogenous Carbohydrate Oxidation
Glucose Metabolism · High Altitude
Primary: Rate of Exogenous Carbohydrate Oxidation — 0.44; 0.35 g/min
N/A N=42 Acute Renal Injury During High Intensity Training
Acute Kidney Injury · Exercise
Primary: Change in Concentration of Proenkephalin-A From Baseline to 4 Time-points Surrounding the Workout — 1.65; 3.69; 2.50; 2.13 pmol/L
Phase 4 N=11 Effect of an H1 Receptor Antagonist on Exercise Performance in Hypoxia
Hypoxia, Altitude
Primary: Performance Time — 17.03; 18.08; 16.32 minutes — p=0.047
N/A N=150 IV Iron for the Anemia of Traumatic Critical Illness
Trauma · ICU Anemia
Primary: RBC Transfusion — 47; 55 participants
N/A N=14 Examining Endogenous Antioxidant Levels in Well Trained Cyclists
Oxidative Stress
Primary: Difference in Resting Levels of Endogenous Antioxidant Proteins in Skeletal Muscle - Superoxide Dismutase 2 (SOD-2) — 0.42; 0.68 Arbitrary Units
N/A N=809 Is Iron Deficiency the Cause of Anemia Among Women in Cambodia?
Anemia · Iron Deficiency · Hemoglobin Disorder
Primary: Hemoglobin Levels at 12-weeks. Marginal Means (95% CI). — 123; 116; 121; 116 g/L — p=<0.05
N/A N=34 The NIH Exercise Therapy for Advanced Lung Disease Trials: Response and Adaptation to Aerobic Exercise in Patients With Interstitial Lung Disease
Interstitial Lung Disease · Idiopathic Pulmonary Fibrosis · Interstitial Pneumonitis
Primary: Change in 6-minute Walk Test Distance (6MWD) — 46.5; 23.2 Meters
N/A N=30 Impact of Nutritional Supplementation on Aerobic Performance and Fatigue
Performance · Fatigue
Primary: Perceived Exertion — 6.7; 7.4 units on a scale
N/A N=47 The Effects of Menstrual Cycle Phase on Exercise Treadmill Test Results in Premenopausal Women
Menstrual Cycle · Exercise Treadmill
Primary: ST/HR Index (μV/Bpm) — 1.2; 1.3 μV/Bpm — p=0.521
Phase 4 N=20 Effectiveness of Ipratropium Bromide in Preventing Exercise-induced Bronchoconstriction in Athletes
Bronchospasm, Exercise-Induced
Primary: Spirometry and Specific Airway Conductance Measured by Body Plethysmography Before and After Exercise Challenge After Randomized Administration of Either Inhaled…
Phase 2 N=26 Nitrites, Exercise, and Peripheral Arterial Disease
Peripheral Arterial Disease
Primary: Change in Exercise Capacity: VO2peak (Maximal Oxygen Consumption) — 1.48; 0.23 ml/kg/min
Phase 3 N=51 Daily vs. Every Other Day Oral Iron Supplementation in Patients With Absolute Iron Deficiency Anemia
Anemia · Iron Deficiency Anemia
Primary: Feasibility of Enrolling Patients in the Trial — 85 participants