N/A N=100 Evaluation of Retinal Microvascular Change That May Develop in After Open Globe Injury
Eye Injury Trauma
Primary: Corneal Thickness — 542.23; 546.16; 544.32 microns
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 2 N=117 Traumatic Optic Neuropathy Treatment Trial (TONTT)
Traumatic Optic Neuropathy
Primary: Number of Participants With Change/Improvement Visual Acuity From the Beseline — 28; 3; 5 Participants
N/A N=26 Eye Movement Recordings in the Diagnosis of Traumatic Brain Injury
Traumatic Brain Injury
Primary: Stability of Fixation — 0.8; 1.1 degrees
N/A N=97 Electric Stimulation of the Eye to Improve Vision After Trauma
Non-arteritic Anterior Ischemic Optic Neuropathy (NAION) · Trauma · Multiple Sclerosis (MS)
Primary: Evaluation of the Effectiveness and Safety of Transcorneal Electrical Stimulation to Improve Visual Acuity — -0.23; -0.14; -0.08; -0.06 logMAR
N/A N=159 Tegaderm vs. EyeGard for Eye Protection
Erythema
Primary: Proportion of Participants With Eyelid Erythema — 117; 105 Participants — p=0.03
N/A N=10 Twenty-four Hour Intraocular Pressure Patterns in Patients With Uncontrolled Thyroid Eye Disease
Thyroid Eye Disease
Primary: Change in IOP Before and After Orbital Decompression Surgery — 18 mVEq (Sensismed Triggerfish output unit)
N/A N=3,345 Modified Instrumentation for Surgery to Correct Trichiasis
Trachoma
Primary: Number of Eyelids With Presence of Recurrent Trichiasis — 948; 1062; 721; 612 eyelids
N/A N=114 Infant Aphakia Treatment Study (IATS)
Congenital Cataract
Primary: Visual Acuity — 0.80; 0.97 logMAR units — p=0.19
N/A N=155 EYE-TRAC Advance: Technology Verification (ETA-TV) Cohort 1
Eye-tracking
Primary: Changes in the Eye-tracking Score Before and After Practice or Game: Phase Error — -0.6; -0.8 Degrees
N/A N=37 Endothelial Bleb Response With Toric Lenses
Ametropia
Primary: Endothelial Bleb Areas on Cornea: Session A- Open Eye — 0.1; 2.0; 0.2; 2.1 Percent Difference of Bleb Area
Phase 2 N=37 A Study of TRS01 in Participants With Post-surgical Ocular Inflammation
Post Surgical Ocular Inflammation
Primary: Assessment of Both Systemic and Ocular Adverse Events — 0; 3; 0; 0 Number of TEAE
N/A N=32 Clinical Investigation of an AcrySof IQ PanOptix Toric Intraocular Lens
Aphakia · Corneal Astigmatism
Primary: Percentage of Eyes With ≤ 0.25 Diopter (D) Absolute Refractive Cylinder at Visit 3/3A (Day 30-60) — 90.2 percentage of eyes — p=<0.0001
Phase 3 N=177 Vascular Endothelial Growth Factor (VEGF) Trap-Eye: Investigation of Efficacy and Safety in Central Retinal Vein Occlusion (CRVO)
Retinal Vein Occlusion
Primary: Percentage of Participants Who Gained at Least 15 Letters in BCVA as Measured by ETDRS Letter Score Compared With Baseline at Week 24 With Discontinued Participants…
N/A N=212 Tube Versus Trabeculectomy (TVT) Study
Glaucoma
Primary: Change in Intraocular Pressure — 12.6; 14.4 mm Hg
N/A N=450 IT Enhanced Peer Integrated Collaborative Care for US Trauma Care Systems
PTSD · Physical Injury
Primary: Number of Patients With 1 or More Emergency Department Visits Per Quarter — 225; 225; 90; 79 Participants
Phase 2 N=10 A Study of the KIO-201 (Ocular Bandage Gel) for Improving Persistent Corneal Epithelial Defects
Persistent Corneal Epithelial Defect
Primary: Percentage of Patients Achieving Corneal Healing (<0.5 mm2 Lesion Size) of the Persistent Corneal Epithelial Defect at 4 Weeks — 5 Participants
N/A N=14 Intense Pulsed Light Study for Dry Eye Disease
Dry Eyes Chronic
Primary: Tear Breakup Time Average — 3.3; 3.0; 4.1; 4.5 Seconds — p=0.3
N/A N=53 LED Therapy for the Treatment of Concussive Brain Injury
Brain Concussion
Primary: Mean Difference in Change in Immediate Post-Concussion Assessment and Cognitive Testing (ImPACT) Score at Baseline and 6 Weeks. — -0.9; -5.78; 3.52; -7.26 Units on a scale
N/A N=135 Performance and Safety Assessment of T4020 in Managing Corneal Epithelial Defect Following Epi-off Accelerated Crosslinking
Keratoconus
Primary: Number of Participants With Complete Healing of Corneal Epithelial Defect at Day 3 — 20; 25 Participants
Phase 3 N=2,410 FLuorometholone as Adjunctive MEdical Therapy for TT Surgery (FLAME) Trial
Trachomatous Trichiasis (TT) · Eye Diseases · Eyelid Diseases
Primary: Incidence of Postoperative TT by One Year, as Determined by Trained Study Team Members — 218; 213; 32; 36 Study eyes — p=0.97
N/A N=28 "Eye Protection After Mydriatic Use for ROP Screening: Impact on Vitals Signs and Pain Scores"
Light Sensitivity
Primary: Heart Rate — 154; 154; 152; 163 Beats per minutes
Phase 3 N=189 Vascular Endothelial Growth Factor (VEGF) Trap-Eye: Investigation of Efficacy and Safety in Central Retinal Vein Occlusion (CRVO)
Macular Edema Secondary to Central Retinal Vein Occlusion
Primary: Percentage of Participants Who Gained at Least 15 Letters in BCVA at Week 24 as Measured by ETDRS Letter Score — 64; 9 percentage of participants — p=< 0.0001
N/A N=68 Light Therapy for Moderate Traumatic Brain Injury
Moderate Traumatic Brain Injury (TBI)
Primary: Safety and Feasibility of Applying Light Therapy After Moderate TBI — 24; 19 Participants
Phase 3 N=406 Intravitreal Aflibercept Injection in Vision Impairment Due to DME
Diabetes Mellitus · Macular Edema
Primary: Change From Baseline in BCVA (Best Corrected Visual Acuity) as Measured by Early Treatment Diabetic Retinopathy Study (ETDRS) Letter Score at Week 52 - Last Observation…
N/A N=10 Magnet for Corneal Foreign Bodies
Corneal Foreign Body
Primary: Success Rate — 1 Participants
N/A N=63 Intraoperative Ocular Pressure in Lumbar Spine Fusion Patients
Raised Ocular Pressure
Primary: Change in Intraoperative Ocular Pressure in Lumbar Spine Fusion Patients Head Raised 10 Degrees or Kept in Neutral Position — 9.26; 13.79 mm Hg
N/A N=50 A Retrospective Evaluation of the Intraocular Pressure Spikes With Loteprednol and Loteprednol/Tobramycin
Ocular Hypertension
Primary: Mean Elevated Intraocular Pressure (IOP) During Treatment — 24.8; 23.9 Millimeters of mercury (mmHg)
N/A N=230 Investigation of the Safety and Effectiveness of Monofocal Toric Intraocular Lens (IOL)
Eye Diseases · Postcataract Aphakia · Cataract
Primary: Mean Residual Manifest Cylinder in Diopters in Toric and Control Arms. — -0.286; -0.813 Diopters — p=<0.0001
N/A N=1,051 Shock, Whole Blood, and Assessment of TBI S.W.A.T. (LITES TO 2)
Hemorrhagic Shock · Traumatic Brain Injury
Primary: 4 Hour Mortality — 50; 32 Participants
Phase 2 N=122 Brain Tissue Oxygen Monitoring in Traumatic Brain Injury (TBI)
Severe Traumatic Brain Injury
Primary: Fraction of Time That Brain Oxygen Levels Are Below the Critical Threshold of 20 mm Hg . — 0.15; 0.44 Proportion