N/A N=45 Adjunctive Steps for Disinfection of Teeth With Primary Endodontic Infections
Periapical Periodontitis · Bacterial Infections
Primary: Metabolic Activity of Persistent Bacteria — 4.748; 2.57; 2.614; 4.0008 RNA/DNA ratio
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=12 Dental Office Prevention Strategies for Children
Dental Plaque
Primary: Dental Plaque Levels Measures on Scale of 0-2 — 0.391 units on a scale
Phase 4 N=471 AUGMENTIN™ in Dental Infections
Focal Infection, Dental
Primary: Percentage of Participants Achieving Clinical Success (Cure or Improvement) Considering Clinical Judgment of the Investigator at the End of Treatment (Day 5 or Day 7)…
Phase 4 N=20 The Effect of Silver Diamine Fluoride (SDF) on Bacteria Involved in Root or Cervical Carious Lesions
Caries
Primary: Change in Bacterial Composition Before and One Month After SDF Application to Root or Cervical Caries Lesions — 1890087; 1959306 bacterial count
Phase 3 N=44 Antibiotic Study for Dental Implants
Periodontitis
Primary: Overall PD Reduction — 1.25; 0.66 mm
N/A N=18 Role of Infected Blood Dendritic Cells in Heart Disease Risk
Chronic Periodontitis
Primary: Frequency of Blood Dendritic Cells From Baseline — 12; 14 % MFI
N/A N=30 Feasibility of IMRT Modulation to Account for Scattered Radiation From Dental Fillings in Head and Neck Cancer
Head and Neck Cancer
Primary: Time Until the Maximum Oral Mucositis Measured From the Start of Radiation Treatment. — 34; 29 Days — p=0.9906
N/A N=42 Resin Infiltration to Arrest Early Tooth Decay
Dental Caries
Primary: Number of Lesions With Progression as Measured by Pairwise (PW) Comparison (N=Lesions) — 4; 14 Lesions — p==0.003
N/A N=73 The Effects of Dexamethasone on the Time to Pain Resolution in Dental Periapical Abscess
Dental Research · Pharmaceutical Preparations, Dental
Primary: Decrease Time of Oral Pain — 9; 9; 5; 4 score on a scale
Phase 3 N=983 Prevention of Adult Caries Study (PACS)
Caries, Dental
Primary: Total Net D12FS Caries Increment (Total of Non-cavitated Lesions (D1), Cavitated Lesions (D2) and Sound Surfaces (S)) — 2.43; 2.68 weighted increment units/13 months…
Phase 4 N=49 Compare Anti-inflammatory Dentifrices
Gingivitis
Primary: Gingival Index (GI) — 1.04; 1.01 units on a scale — p=<0.05
N/A N=17 Radiographic Progression of Infiltrated Caries Lesions In-vivo
Dental Caries
Primary: Number of Lesions Showing Radiographic Progression as Measured by Lesion Size (Continuous) — 2; 11 Lesions — p=0.002
Phase 3 N=394 Healozone Study to Evaluate the Safety and Efficacy of the Use of Ozone for Management of Dental Caries
Dental Caries
Primary: ICDAS Severity Value — 17; 22; 278; 273 teeth — p=0.1126
N/A N=69 IFI16 is a Periodontitis Modulating Protein
Severe Periodontitis · Acute Inflammatory Response
Primary: Change in Absent in Melanoma 2 (AIM2) mRNA Expression Levels — 0.37; 0.65 fold change — p=0.3
Phase 3 N=323 Preventing and Arresting Dental Root Surface Caries in Community-dwelling Older Adults
Dental Caries
Primary: Number of New Tooth Root Caries Lesions — 1.1; 0.43; 0.56 new carious root surfaces
N/A N=108 Effect of Root Canal Treatment (Versus no Treatment) for Patients With Tooth Infections and Toothaches
Postoperative Pain
Primary: Percent of Patients With Success as Defined by no or Mild Pain as Analyzed on a VAS Scale and no Narcotic Use — 52; 43 percentage of participants
N/A N=50 Nobio Clinical Study - Demineralization Prevention With a New Antibacterial Restorative Composite
Dental Caries · Denture, Partial, Removable
Primary: Mineral Loss ΔZ — 235; 774 vol% * μm]
Phase 2 N=345 Non-invasive Treatment of Root Caries in Older Adults
Root Caries
Primary: Root Caries Activity — 3.72; 40.52 Percentage of active lesions (2-years)
Phase 2 N=117 OZONE_EXO: Comparative Analysis of Protocols for Dental Exactions in Patients at Risk of MRONJ: Case-control Study
MEDICATION RELATED OSTEONECROSIS OF THE JAW
Primary: Healing Evaluation Using Inflammatory-Proliferative-Remodelling Scale (IPR Scale): Inflammatory Phase — 2; 2.49 score on a scale
N/A N=51 Kidney and Periodontal Disease Study
Chronic Kidney Disease · Periodontal Disease
Primary: Number of Participants Completing Study Protocol — 17; 34; 14; 30 Participants
Phase 3 N=102 Periodontal Infection and Endothelial Dysfunction
Periodontitis
Primary: Brachial Artery Flow-mediated Dilation — 10.2; 10.3; 13.1; 8.1 Percentage of dilatation of brachial art — p=0.98
N/A N=4 Nanodiamond Modified Gutta Percha (NDGP) Composite for Non-surgical Root Canal Therapy (RCT) Filler Material
Dental Pulp Diseases · Dental Pulp Necrosis · Nerve Root Pain Nec
Primary: Percent Reduction in Apical Radio-lucency — 17.4; 27.1 % Change in Diameter (mm)
Phase 4 N=32 A New Clinical Use of Ferumoxytol Nanoparticles: An Antibiofilm Treatment
Apical Periodontitis · Pulp Disease, Dental
Primary: The Primary Outcome Parameter Will be the Difference in Bacterial Reduction Between the Experimental and Control Disinfection Groups Group (Ferumoxytol) and Comparison…
N/A N=30 Implant Surface Decontamination in Peri-implantitis Treatment
Peri-implantitis · Periodontal Disease
Primary: Change in Total Bacterial Load on the Exposed Implant Surface — 2.77; 4.21 log (colony forming units/ml)
N/A N=61 Trial of Toothpaste to Reduce Plaque and Inflammation
Plaque · Inflammation
Primary: Change in Oral Plaque — -1.05; -0.03 log(percentage) — p=0.001
Phase 3 N=44 Antibacterial Effect of Nano Silver Fluoride vs Chlorhexidine on Occlusal Carious Molars Treated With Partial Caries Removal Technique
Dental Caries
Primary: Bacterial Count of Streptococus Mutans — 2.00; 2.04; 1.12; 1.05 CFU/ml log10
N/A N=41 Longitudinal Study of Dental Implant Therapy in HIV Positive Patients
Dental Implant
Primary: Number of Implants Functioning in HIV Positive Subjects Compared to HIV Negative Subjects — 28; 25 implants
Phase 4 N=70 Scaling and Root Planing (SRP) With and Without Minocycline HCl Microspheres, 1 mg
SRP · Minocycline HCl Microspheres · Biomarkers
Primary: Bacteria Load (log10) — -11.3; -10.9 log 10 copies/mL
N/A N=68 Comparison of Oral Hygiene & Root Resorption During Orthodontic Treatment
Orthodontic Pathological Resorption of External Root · Complication of Personal Oral Hygiene
Primary: Plaque Index — 0.5; 0.7; 0.7; 0.8 Plaque Index (PI)
Phase 3 N=315 Effect of pH and Fluoride Concentration of Dentifrices on Caries Control
Dental Fluorosis · Dental Caries
Primary: Evaluation of the Concentration of Fluoride Incorporated Into the Biofilm Done 6 Months After Initiation of Dentifrices Use. — 0.80; 1.32; 1.74 mmol/kg — p=<0.05