Phase 4 N=20 Effect of Exenatide in Obese Patients With Accelerated Gastric Emptying
Obesity
Primary: Gastric Emptying Half-time (T 1/2) of Solids — 187; 86 minutes — p=<.001
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=100 Gastric Ultrasound
Surgery
Primary: Aspiration Risk Grade — 30; 30; 20; 9 Participants
N/A N=10 Does Adding Milk to Tea Delay Gastric Emptying?
Gastric Emptying
Primary: Tmax — 38; 30 minutes
N/A N=30 Carbon-13 (13C)-Spirulina Platensis Gastric Emptying Breath Test (GEBT)
Dyspepsia
Primary: Gastric Emptying Half Time Measured by Scintigraphy — 65.9; 82.2 minutes
Phase 2 N=57 A Study to Assess the Effect of Repeat Doses of GSK962040 on the Pharmacokinetics of L-DOPA in Subjects With Parkinson's Disease Exhibiting Delayed Gastric Emptying
Gastroparesis
Primary: Dose-normalized Levodopa (L-DOPA) Area Under the Plasma Concentration-time Curve From Zero to 4 Hours AUC(0-4) at Baseline — 24.13; 24.81…
Phase 4 N=65 A Study of Gastrointestinal Emptying Time in Adult Participants With Migraine Before and After Start of a mAb CGRP Antagonist
Migraine
Primary: Change From Baseline in Colonic Transit Time (CTT) at Week 2 — 5.752; -5.348 hours
Phase 3 N=58 Temporary Gastric Electrical Stimulation for Drug Refractory Gastroparesis
Gastroparesis
Primary: Symptom of Vomiting Associated With Gastroparesis — 1.82; 2.68; 0.17; 1.20 Patient Self-reported Symptom Score
Phase 2 N=25 Safety, PK and Efficacy of PCS12852 on Gastric Emptying Rate in Patients With Moderate to Severe Gastroparesis
Gastroparesis
Primary: Change in Gastric Emptying Rate From Baseline as Determined by the Area Under the Curve (AUC) of the Gastric Emptying Rate — 267.12; 283.09; 221.74 kPCD/minutes — p=<0.05
Phase 2 N=27 Effects of Tradipitant on Satiation, Gastric Volume, Gastric Accommodation, and Gastric Emptying in Healthy Volunteers
Healthy Volunteer
Primary: Fasting Gastric Volume as Measured by Single Photon Emission Computed Tomography (SPECT) — 178.8; 191.1 mL
Phase 2 N=36 Effect of TAK-954 on Gastrointestinal and Colonic Transit in Diabetic or Idiopathic Gastroparesis Participants
Diabetic Gastroparesis · Idiopathic Gastroparesis
Primary: Percent Change From Baseline in Half-emptying Time (T1/2) of Gastric Solids — 3.5; -19.8; -25.4; -25.7 percent change — p=0.0012
Phase 1 N=36 A Study to Measure Stomach Emptying in Overweight Non-diabetic and Diabetic Participants Using Tirzepatide
Overweight · Obesity · Diabetes Mellitus, Type 2
Primary: Pharmacokinetics (PK): Area Under the Concentration Time Curve From Time Zero to Time T, Where T is the Last Time Point With a Measurable Concentration [ AUC(0-tlast)]…
N/A N=449 Residual Gastric Volume in Same Day Versus Split Dose and Evening Before Bowel Preparation
Esophagogastroduodenoscopy · Colonoscopy
Primary: Residual Gastric Volumes of Different Bowel Preparation Regimens — 19; 16; 18 mL
N/A N=24 Effect of Vibrant Capsule on Gastric Emptying and Antropyloroduodenal Motility in Healthy Volunteers
Gastroparesis
Primary: Gastroduodenal Manometry Measurement — 9.862; 10.38; 10.38; 8.433 motility index units (see Description)
Phase 4 N=60 Holding vs. Continuing Incretin-based Therapies Before Upper Endoscopy
Diabetes Mellitus, Type 2 · Obesity · Gastroparesis
Primary: Presence of RGV (Residual Gastric Volume) in Stomach — 7; 1 Participants
Phase 1 N=38 A Study to Evaluate the Effect of LY2189265 on the Speed at Which Food and Drink Leaves the Stomach in Patients With Type 2 Diabetes Mellitus
Diabetes Mellitus, Type 2
Primary: Time Required for 50% of Radioactivity To Be Emptied From the Stomach by Scintigraphy — 1.44; 1.72; 1.41; 3.77 hours
Phase 2 N=79 Dose Response of 28 Days of Dosing of GSK962040 in Type I and II Diabetic Male and Female Subjects With Gastroparesis
Gastroparesis
Primary: Gastric Half Emptying Time (GEt1/2) — 131.2; 106.5; 118.2; 131.1 Minutes
N/A N=592 Residual Gastric Volume Measured by Ultrasound in Diabetic Surgical Population Versus Non-diabetic Surgical Population.
Diabetes Mellitus
Primary: Residual Gastric Volume — 22.1; 33.1; 40.2 mL — p=<0.05
Phase 3 N=20 TREXIMA and RELPAX Gastric Scintigraphy Inside and Outside a Migraine
Migraine Disorders
Primary: Time to 10%, 50%, 90% and Complete Gastric Empting of the Radioactive Markers Representing Sumatriptan, Naproxen and Eletriptan — 0.100; 0.130; 1.195; 1.300 hours (hr)
N/A N=60 Dose Response of Intravenous Sincalide(CCK-8) for Gallbladder Emptying
Healthy
Primary: Coefficient of Variation (CV) for Gallbladder Ejection Fraction (GBEF) for Each Infusion Method — 51.66; 62.75; 71.38; 40.46 percentage
Phase 2 N=20 A Pilot Study of Hemin Therapy for Gastroparesis (Diabetes Mellitus)
Gastroparesis · Diabetes Mellitus
Primary: Venous Plasma Heme-oxygenase 1 (HO1) Protein Concentration — 1.6; 1.5; 10.6; 1.5 ng/mL — p=0.0002
Phase 4 N=12 Pharmacokinetics of Immediate-Release vs. Delayed-Release Omeprazole in Gastroparesis
Gastroparesis · Gastroesophageal Reflux Disease
Primary: Time to Maximal Omeprazole Concentration (Tmax) — 32; 97 minutes — p=< 0.01
Phase 2 N=40 Pilot Study of the Effect of Liraglutide on Weight Loss and Gastric Functions in Obesity
Obesity
Primary: Gastric Emptying of Solids Half-time (T1/2) at 5 Weeks — 180; 117 minutes
Phase 3 N=40 Using Magnetic Resonance (MR) to Understand the Effect of Erythromycin on Bowel Motility
Healthy
Primary: Gastric Volume — 262; 718 mL — p=<0.0001
N/A N=88 Gastrointestinal Myoelectric Activity Protocol, the G-Tech EEnG Protocol
Gastrointestinal Diseases
Primary: Device Success Defined as the Ability to Record Myoelectric Signals in Study Subjects. — 88 participants
N/A N=146 Aspiration of Residual Gastric Contents
Infant, Premature · Nutrition, Enteral
Primary: Enteral Intake on Day of Life 7 — 27.5; 22.6 mL/kg per day — p=0.27
N/A N=20 Magnetically Controlled Capsule Endoscopy Feasibility Study in Gastric Motility
Gastroparesis · Dyspepsia
Primary: Frequency of Contractions at Baseline — 20; 24.6; 23.7 stomach contractions/minute
Phase 2 N=136 Pilot Study of the Effect of Liraglutide 3.0 mg on Weight Loss and Gastric Functions in Obesity
Obesity
Primary: Gastric Emptying of Solids (T1/2) — 191.6; 105.9 minutes
N/A N=62 Comparison Between Pyloric Preserving and Non-Pyloric Preserving Bariatric Surgery With Glucose Challenge
Hypoglycemia · Obesity
Primary: Mean Serum Glucose Levels — 123.1; 157.5; 103.2; 138 mg/dl
N/A N=5 Gastrectomy, Eating Behaviour and GLP-1
Gastric Cancer · Dumping Syndrome
Primary: Nadir Blood Glucose — 3; 4.4 mmol/l — p=0.008
Phase 4 N=96 Impact of Oral Application of Gastrografin on the Meconium Evacuation in Very Low Birth Weight Infants
Meconium Ileus · Very Low Birth Weight Infant
Primary: Time to Complete Meconium Evacuation in Days — 7; 8 days of life — p=0.61