Phase 4 N=49 Compare Anti-inflammatory Dentifrices
Gingivitis
Primary: Gingival Index (GI) — 1.04; 1.01 units on a scale — p=<0.05
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Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=32 Induced Gingivitis & Intra-oral Imaging
Plaque Induced Gingivitis
Primary: Change From Baseline Gingivitis at Day 14 as Measured by Non-invasive Microimaging and Gingival Index. — 0.6; 0.15 units on a scale
Phase 4 N=49 Evaluate Inflammation Caused by Gingivitis in Adults
Gingivitis
Primary: Level of Gingival Crevicular Fluid Interleukin - 1 (GCF IL-1) at 2 Hours — 492.2; 326.3 Micrograms — p=0.05
Phase 3 N=39 Collection of Gingival Crevicular Fluid From Periodontitis Patients
Gingival Diseases
Primary: Metabolite Associated With Inflammation (Cadaverine) — 1.119186; 0.92077 ion count — p=<0.05
N/A N=48 Gingival Bleeding and Von Willebrand Disease Typ 2 and 3
Gingival Bleeding · Von Willebrand Diseases
Primary: Bleeding on Probing (BOP) — 14.5; 12.3 percentage of sites
N/A N=200 A Clinical Study to Evaluate Effects of an Oral Rinse on Plaque and Gingivitis
Plaque
Primary: Plaque Index Score Per Participant at 6 Months — 2.12; 2.70; 2.23; 2.84 score on a scale — p=<0.0001
Phase 3 N=19 Investigation of Dental Plaque and Gingival Index
Dental Plaque
Primary: Gingival Margin Plaque Index — 15.4; 12.81 Units on a scale — p=0.05
Phase 2 N=71 Safety and Tolerability of Antiplaque Chewing Gum in a Gingivitis Population
Plaque · Gingivitis
Primary: Safety and Tolerability of KSL-W as Measured by Soft Tissue Erythema, Ulceration and Sloughing (AEs and SAEs) — 2; 1; 4; 2 Participants
N/A N=153 Study of an Experimental Toothbrush for Treatment and Prevention of Gingivitis
Dental Devices, Home Care
Primary: Whole-mouth Mean Modified Gingival Index (MGI) Score at Day 42 — 1.880; 1.770 Unit on a scale
N/A N=55 Powertoothbrushing for Treating Gingivitis
Gingivitis
Primary: Change in Gingivitis — 0.14; 0.19 score on a scale
Early Phase 1 N=35 Dose-dependent Anti-inflammatory Effects of Vitamin D in a Human Gingivitis Model
Gingivitis
Primary: Proportion of Sites That Bleed on Probing
Phase 2 N=127 Safety and Preliminary Efficacy of Lipoxin Analog BLXA4-ME Oral Rinse for the Treatment of Gingivitis
Gingival Inflammation
Primary: Incidence of Adverse Events — 19; 10; 3 Participants
N/A N=69 IFI16 is a Periodontitis Modulating Protein
Severe Periodontitis · Acute Inflammatory Response
Primary: Change in Absent in Melanoma 2 (AIM2) mRNA Expression Levels — 0.37; 0.65 fold change — p=0.3
Phase 4 N=69 Cetylpyridium Chloride (CPC) Based Chewing Gum and Gingivitis
Gingivitis · Plaque, Dental · Periodontal Diseases
Primary: Degree of Plaque as Assessed by the Turesky Modification of the Quigley-Hein Plaque Index — 0.41; 0.43 score on a scale
Phase 3 N=44 Clinical Study to Evaluate the Treatment of Gingivitis of Two Toothpastes
Dental Plaque
Primary: Control Established Plaque in Adults — 2.42; 2.45 Units on a scale — p=<0.05
Phase 3 N=73 Clinical Research Study Efficacy of a Prototype Oral Rinse
Dental Plaque
Primary: Gingival Index — 1.90; 1.84 Units on a scale — p=0.005
Phase 2 N=120 Assessing Gingivitis of 3 Different Dentifrices Compared to a Negative Control.
Gingivitis
Primary: Number Bleeding Sites — 31.52; 25.90; 21.65; 19.13 number of bleeding sites
N/A N=253 Potential of Stannous Fluoride Toothpaste to Reduce Gum Disease
Gingivitis
Primary: Number of Bleeding Sites at Week 12 — 42.02; 67.36 number of bleeding sites — p=<0.0001
N/A N=158 A Clinical Trial to Test the Effect of Marketed Mouth Rinses on Decreasing Plaque and Gum Inflammation
Plaque · Gingivitis
Primary: Whole Mouth Mean Modified Gingival Index (MGI) at Week 3 — 2.004; 1.770; 1.807 units on a scale — p=<0.001
Phase 2 N=60 Efficacy of ClōSYS® Sensitive Fluoride Toothpaste and ClōSYS® Sensitive Rinse Regimen on MGI, PI and BOP
Gingivitis · Periodontitis
Primary: Changes in Modified Gingival Index (MGI) — 8.5; 1.5 score on a scale — p=<0.001
N/A N=32 Study of the Anti-Inflammatory Effects of Colgate Total® During an Experimental Gingivitis Model
Gingivitis
Primary: Change From Baseline in Plaque Index (Silness & Loe 1964) to Day 35 — 0.37; 0.44; 1.24; 1.49 units on a scale
N/A N=34 Effect of Non-surgical Periodontal Therapy on Gingival Crevicular Fluid Interleukin-21 Levels
Chronic Peridontitis Patients · Chronic Gingivitis · Healthy
Primary: Pocket Depth — 1.60; 2.50; 6.75 millimetres
Phase 2 N=110 A Proof-of-principle Clinical Study Investigating the Efficacy of an Experimental Dentifrice Containing Sodium Bicarbonate and Sodium Hyaluronate on Gingivitis
Gingivitis
Primary: Number of Bleeding Sites at 6 Weeks (Comparison of Experimental Versus Negative Control Dentifrice) — 9.5; 20.5 Number of Sites — p=<0.0001
N/A N=80 Iranian Traditional Mouth Rinse Punica Granatum Pleniflora (Golnaar) in Treatment of Gingivitis in Diabetic Patients
Gingivitis
Primary: Plaque Index — 2.3; 2.5; 1.9; 2 units on a scale
N/A N=62 A Clinical Trial to Evaluate Long-term Efficacy and Safety of Lozenges Containing Lactobacilli Reuteri (Prodentis™) on Gingivitis
Gingivitis
Primary: Change From Baseline in Modified Gingival Index (MGI) — -0.07; -0.09; -0.09; -0.02 units on a scale
Phase 4 N=130 A Clinical Study Investigating the Efficacy of a Stannous Fluoride Dentifrice in Improving Gingival Health After Twice Daily Use for 3 Weeks
Gingivitis
Primary: Whole Mouth Mean Bleeding Index (BI) at Week 3 — 0.14; 0.20 score on a scale — p=<0.0001
Phase 3 N=98 A Phase 3 Clinical Study Investigating the Gingivitis Efficacy of a Test Dentifrice Containing Stannous Fluoride
Gingivitis
Primary: Evaluation and Comparison of Gingival Health Measured by Bleeding Index (BI) at 24 Weeks — 0.11; 0.19 Score on scale — p=<0.0001
Phase 4 N=113 Relationship of Periodontal Disease Treatment and Type 2 Diabetes Mellitus in the Gullah Population
Periodontal Disease · Type 2 Diabetes Mellitus
Primary: Glycated Hemoglobin A1c — 8; 8.2 percentage of Glycated Hemoglobin A1c
N/A N=51 Kidney and Periodontal Disease Study
Chronic Kidney Disease · Periodontal Disease
Primary: Number of Participants Completing Study Protocol — 17; 34; 14; 30 Participants
Phase 2 N=162 The Clinical Investigation of a Zinc Based Toothpaste in Reducing Plaque and Gingivitis
Dental Plaque and Gingivitis
Primary: Gingivitis Scores — 1.48; 1.57; 1.49 units on a scale — p=0.091