Phase 2 N=32 Gulf War Illness: Evaluation of an Innovative Detoxification Program
Gulf War Illness
Primary: Short Form-36 for Veterans Quality of Life Physical Component Summary Scores — 30.3; 36.7; 38.2; 35.7 score on a scale — p=<0.05
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 2 N=83 Gulf War Illness Inflammation Reduction Trial
Chronic Inflammation · Chronic Pain · Fatigue
Primary: Change From Baseline of Veterans RAND 36-Item Health Survey Physical Component Summary Score (PCS) Scores at 8 and 16 Weeks — 40.8; 41.5; 43.5; 43.4 units on a scale
N/A N=268 Cognitive Rehabilitation for Gulf War Illness
Gulf War Illness
Primary: Disability - WHO-DAS 2 Change — -2.81; -2.21 score on a scale — p=0.712
N/A N=54 Gulf War Digestive Health Study
Irritable Bowel Syndrome · Small Intestinal Bacterial Overgrowth
Primary: Global Improvement Scale — 4.3; 4.3 units on a scale — p=0.26
N/A N=149 CAM in Veterans With Gulf War Illnesses
Gulf War Veterans' Illness
Primary: Veterans RAND 36-item Health Survey - Mental Component Summary Scale — 42.26; 41.75; 44.48; 40.62 score on a scale
N/A N=27 Vagus Nerve Stimulation: Treatment for Gulf Veterans With Gulf War Illness
Pain · Migraine
Primary: Visual Analog Scale (VAS) to Assess Change of Widespread Pain — 4.70; 5.40; 5.43; 3.56 Units on a scale — p=0.47
Phase 2 N=104 Acupuncture in the Treatment of Gulf War Illness
Persian Gulf Syndrome
Primary: SF-36P — 73.7; 64.3 units on a scale — p=0.03
N/A N=85 Cognitive Behavioral Therapy for Insomnia for Gulf War Illness
Gulf War Illness · Insomnia
Primary: Gulf War Illness Symptom Severity Index — 67; 67; 61; 49 score on a scale — p=<0.01
Phase 2 N=170 Complementary Neurosteroid Intervention in Gulf War Illnesses (GWVI)
Fatigue · Musculoskeletal Pain · Cognitive Decline
Primary: Physical Component of the SF-36 — 2.04; 2.55; 1.23; 4.45 score on a scale
N/A N=838 Prospective Study of Veteran Health in Previously Deployed Soldiers
Combat Disorders
Primary: Non-Specific Physical Symptoms — 5.2; 7.9; 7.7; 7.7 units on a scale
Phase 2 N=40 Gulf War Illness Nasal Irrigation Study
Persian Gulf Syndrome · Chronic Sinusitis · Fatigue
Primary: Change in Sino-Nasal Outcome Test (SNOT-20) Score From Baseline — -16.9; -8.8; -3.4; -18.9 score on a scale
N/A N=114 Novel Interventions for GWVI
Gulf War Veteran's Illness
Primary: Change in Brief Pain Inventory - Short Form (BPI) - Pain Interference — 4.47; 4.77; 3.59; 3.66 score on a scale — p=0.58
N/A N=75 Treating Chronic Pain in Gulf War Illness
Chronic Pain · Gulf War Illness · Chronic Illness
Primary: Pain (Brief Pain Inventory - Short Form) - Pain Severity — -.87; -.24 units on a scale — p=.25
Phase 3 N=100 Coenzyme Q10 Phase III Trial in Gulf War Illness
Gulf War Illness · Chronic Fatigue · Ubiquinol
Primary: Veterans Short Form 36-Item Health Survey Physical Component Summary — 1.6; -1.1; 1.4; 1.1 units on a scale
N/A N=96 Effects of Botanical Microglia Modulators in Gulf War Illness
Gulf War Illness
Primary: Change From Baseline in Overall Gulf War Illness Disease Severity — 13; 0; 8; -1 units on a scale
N/A N=29 Sleep Disordered Breathing in Gulf War Illness and the Effect of Nasal CPAP Treatment
Apnea, Sleep · Chronic Fatigue Syndrome
Primary: Change of Fatigue Symptom — 2.1; 0.2 units on a scale — p=0.0002
N/A N=55 Mindfulness-Based Stress Reduction for Gulf War Syndrome
Persian Gulf Syndrome
Primary: The Short-form McGill Pain Questionnaire — 54.0; 65.5 units on a scale
N/A N=49 Assessing Neuroinflammation in GWI Using MRS
Gulf War Syndrome
Primary: Concentration of Myoinositol in the Brain — 0.001260; 0.001205 Institutional Units (IU)
N/A N=54 Impact of Exercise Training on Pain and Brain Function in Gulf War Veterans
Chronic Musculoskeletal Pain
Primary: Short Form McGill Pain Questionnaire Visual Analog Scale (VAS). — 29.82; 37.08; 30.07; 31.46 units on a scale — p=0.680
Phase 2 N=33 Treatment Study of Carnosine Versus Placebo in Gulf War Illness (GWI)
Persian Gulf Syndrome
Primary: Effect of Carnosine Supplementation on Chronic Fatigue Syndrome Severity Scores — -3.8; -2.0 units on a scale — p=0.30
N/A N=21 Management of Chronic Pain and PTSD in Gulf War Veterans With tDCS+Prolonged Exposure
Chronic Pain · PTSD
Primary: Feasibility of Recruitment as Assessed by Number of Participants Enrolled in the Study — 21 Participants
N/A N=63 Scalp Application of LED Therapy to Improve Thinking and Memory in Veterans With Gulf War Illness
Gulf War Veterans Illness · Neurobehavioral Manifestations · Memory Disorders
Primary: Digit Span Forwards — 8.7; 9.22; 8.33; 9.36 units on a scale — p=<0.01
N/A N=50 Predictors of Response to Insomnia Treatments for Gulf War Veterans
Insomnia
Primary: Insomnia Severity Index (ISI) — 17.0; 18.9; 7.3; 10.9 score on a scale
N/A N=245 Groups for Regaining Our Wellbeing
Gulf War · Fatigue · Pain
Primary: Short Form McGill Pain Questionnaire (SF-MPQ-2) Total Score — 69.2; 64.9; 62.3; 55.5 score on scale
N/A N=50 Effects of Deployment Exposures on Cardiopulmonary and Autonomic Function
Abnormality, Respiratory System · Autonomic Nervous System
Primary: FEV1 — 0.94; 1.08; 0.95; 1.09 percentage of predicted normal values
N/A N=1,242 Service and Health During the Iraq and Afghanistan Era
Iraq and Afghanistan Era Veterans
Primary: Participation Rates — 137; 121; 14 Participants
N/A N=128 Cognitive Rehabilitation of Operations Iraqi Freedom and Enduring Freedom (OIF/OEF) Veterans With Cognitive Disorder
Cognition Disorders
Primary: Multiple Sclerosis Neuropsychological Screening Questionnaire-Patient Version — 33.58; 36.35 units on a scale
N/A N=155 Treatment of Prolonged Grief Disorder in Combat Veterans
Prolonged Grief Disorder
Primary: Inventory of Complicated Grief - Revised (ICG-R) — 93.15; 93.10 score on a scale
N/A N=103 Establishing Efficacy of a Functional-Restoration Based CAM Pain Management Program in Post-9/11 Veterans
Chronic Pain · Traumatic Brain Injury · Posttraumatic Stress Disorder
Primary: Change in Oswestry Disability Index (ODI) — 48.6; 45.1; 38.3; 47.8 score on a scale — p=.001
N/A N=145 Trauma Informed Guilt Reduction Therapy
Guilt · Shame · Post-traumatic Stress Disorders
Primary: Trauma Related Guilt Inventory - Guilt Severity — 2.5; 2.5; 1.6; 2.2 score on a scale