Phase 2 N=18 Hyperbaric Treatment of Traumatic Brain Injury (TBI)
Traumatic Brain Injury
Primary: Number of Participants With Improved Cerebral Perfusion — 8 Participants
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 3 N=160 Metoclopramide for Post Traumatic Headache
Post-Traumatic Headache
Primary: 0-10 Pain Scale on Which 0 = no Pain and 10= the Worst Pain Imaginable — 5.2; 3.8 units on a scale
N/A N=120 Neurocognitive Evaluation of Mild Traumatic Brain Injury in the Hospitalized Pediatric Population
Mild Traumatic Brain Injury · Concussion
Primary: The Feasibility of Inpatient Bedside Neurocognitive Testing of Pediatric Patients With Minor Traumatic Brain Injury. — 120 participants
Phase 2 N=122 Brain Tissue Oxygen Monitoring in Traumatic Brain Injury (TBI)
Severe Traumatic Brain Injury
Primary: Fraction of Time That Brain Oxygen Levels Are Below the Critical Threshold of 20 mm Hg . — 0.15; 0.44 Proportion
N/A N=971 Shared Decision Making in Parents of Children With Head Trauma: Head CT Choice
Head Injury
Primary: Assess Parents' Knowledge Regarding Their Child's Risk for a Significant Brain Injury — 6.2; 5.26 Number of questions correct out of 10
N/A N=73 Rapid MRI for Acute Pediatric Head Trauma
Head Trauma · Image, Body
Primary: Sensitivity: Percentage of MRIs Correctly Identifying Clinically Important Intracranial Injury (True Positives) — 70 Percentage of MRIs correctly identifying
N/A N=1,051 Shock, Whole Blood, and Assessment of TBI S.W.A.T. (LITES TO 2)
Hemorrhagic Shock · Traumatic Brain Injury
Primary: 4 Hour Mortality — 50; 32 Participants
Phase 2 N=21 Metoclopramide for Post-Traumatic Headache. A Pilot Study
Post-Traumatic Headache
Primary: Number of Participants With Sustained Headache Relief — 12 Participants
N/A N=68 Light Therapy for Moderate Traumatic Brain Injury
Moderate Traumatic Brain Injury (TBI)
Primary: Safety and Feasibility of Applying Light Therapy After Moderate TBI — 24; 19 Participants
N/A N=1,516 Brain Injury Rehabilitation Improving the Transition Experience
Traumatic Brain Injury
Primary: Participation Assessment With Recombined Tools - Objective 17 (PART-O-17) — 1.30; 1.33 units on a scale — p=0.44
N/A N=38 Acupuncture in Traumatic Brain Injury
Chronic Post-traumatic Headache · Mild Traumatic Brain Injury
Primary: Change in Number of Headache Days — -8; -6 headache days
N/A N=6 Deep Brain Stimulation for the Treatment of Traumatic Brain Injury
TBI (Traumatic Brain Injury)
Primary: Percent Change in Trail Making Test Part B Time to Completion — -25.6 percent change in time
N/A N=15 Q-collar and Brain Injury Biomarkers
Concussion
Primary: Longitudinal DTI Changes — 0.000809; 0.000760; 0.000763; 0.000843 voxels
Phase 4 N=15 Anterior Pituitary Hormone Replacement in Traumatic Brain Injury
Growth Hormone Deficiency · Traumatic Brain Injury
Primary: Maximum Oxygen Uptake at Baseline. — 29.0 mL/kg/min
Phase 2 N=50 Treatment of Traumatic Brain Injury With Hyperbaric Oxygen Therapy
Brain Injury, Chronic
Primary: Computer Cognitive Test Scores - ImPACT Verbal Memory — 70.48; 74.21; 78.12; 75.36 units on a scale
Phase 2 N=40 Sumatriptan as Treatment for Post-traumatic Headache
Post-traumatic Headache
Primary: Change in Headache Relief — 23 percentage of headaches resolved — p=.079
Phase 2 N=1,063 Prehospital Tranexamic Acid Use for Traumatic Brain Injury
Traumatic Brain Injury
Primary: Dichotomized Glasgow Outcome Scale Extended (GOS-E) at 6 Months — 107; 108; 110; 218 Participants — p=.1809
N/A N=193 Cognitive-Behavior Therapy for Posttraumatic Headache
Post-traumatic Headache · PTSD
Primary: Headache-related Disability Scores on the Headache Impact Test 6 (HIT-6) — 66.1; 66.1; 65.2; 61.9 score on a scale — p=<0.001
N/A N=62 Protection Against Potential Brain Injury During Competitive Football
Concussion
Primary: Determine Average Number of Hits Between Groups — 896.43; 795.40; 144.67; 145.85 number of hits
N/A N=27 Yoga and Female Concussion
Concussion Mild
Primary: Post Traumatic Growth — 41.7; 57.8; 40.4; 60.7 Score on a scale
N/A N=21 Translational Research Examining Acupuncture Treatment in Traumatic Brain Injury
Traumatic Brain Injury
Primary: Cerebral Blood Flow Velocity in the Left (L) and Right (R) Middle Cerebral Artery (MCA), Internal Carotid Artery (ICA), and Basilar Artery (BA). — 3.2; 6.7; 4; 12.7 ml/sec
N/A N=26 Eye Movement Recordings in the Diagnosis of Traumatic Brain Injury
Traumatic Brain Injury
Primary: Stability of Fixation — 0.8; 1.1 degrees
N/A N=97 Traumatic Brain Injury (TBI) Screening Instruments
Brain Injury
Primary: Responses From the TBI Clinical Reminder — 61; 88 percentage of participants
N/A N=23 Optimizing Cognitive, Environmental, and Neuromotor Stimulation in Traumatic Brain Injury
Traumatic Brain Injury · Dementia Alzheimers · Military Activity
Primary: Change in Executive Functioning as Assessed by the Trail Making Test — -9.2; 24.7 change in seconds — p=.323
Phase 2 N=50 Resuscitative Endocrinology:Single-dose Clinical Uses for Estrogen-Traumatic Brain Injury
Traumatic Brain Injury
Primary: Percent Passing the Galveston Orientation Amnesia Test (GOAT) Within 28 Days Post Injury — 12; 14 Participants — p=0.99
N/A N=40 Transcranial Direct Current Stimulation for the Treatment of Deficits After Traumatic Brain Injury
Traumatic Brain Injury · Post Concussive Symptoms · Depression
Primary: Examiner Score — 0.617; 0.907; 0.865; 1.155 score on a scale
Phase 4 N=162 Dexamethasone for Post Traumatic Headache
Post-Traumatic Headache
Primary: Frequency of Moderate or Severe Headache After Emergency Department (ED) Discharge — 31; 29; 42; 44 Participants — p=0.751
Phase 1 N=62 Delayed Versus Early Enoxaparin Prophylaxis After Traumatic Brain Injury (TBI)
Venous Thromboembolism · Traumatic Brain Injury
Primary: Percentage of Participants With Worsening TBI Hemorrhage — 5.9; 3.6 percentage of participants
N/A N=24 Adjuvant Acupuncture for Severe Head Injury
Head Injury
Primary: Glasgow Coma Scale (GCS) — 3.14; 3.11; 4.67 units on a scale
N/A N=79 Managing Mild Traumatic Brain Injury Related Headaches With Repetitive Transcranial Magnetic Stimulation
Traumatic Brain Injury (TBI)
Primary: Number of Headache Days Per Week — 4.2; 4.6; 3.1; 4.3 days/week — p=<0.000