N/A N=22 Impact of Low-dose Tamoxifen on BPU
High Background Uptake on MBI
Primary: Change in Background Parenchymal Uptake (BPU) on Molecular Breast Imaging (MBI) — 0.0; -12 percent change in BPU
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=60 The Assessment of Molecular Breast Imaging (MBI) in Distinguishing Benign From Malignant Breast Disease
Breast Abnormalities
Primary: Specificity of MBI. Specificity is Defined as the Number of True Negatives/ Total Number of Negative Pathology Results. — 27 lesions
N/A N=1,638 Low Dose Molecular Breast Imaging as a Screening Tool for Women With Dense Breasts
Breast Cancer
Primary: Cancer Detection Rate Per 1000 Women Screened, by Breast Density — 3.2; 12.0; 10.7; 0 cancers per 1000 women screened — p=<0.001
N/A N=82 Evaluation of Half-Dose Molecular Breast Imaging With Wide Beam Reconstruction Processing
Breast Cancer
Primary: Compare the Diagnostic Accuracy of 8 mCi Molecular Breast Imaging (MBI) With 4 mCi MBI. — 30; 29 cancers detected
N/A N=2,978 Molecular Breast Imaging and Digital Breast Tomosynthesis in Screening Patients With Dense Breast Tissue
Breast Carcinoma
Primary: Rate of Detection of Invasive Cancers — 9; 14 Participants
N/A N=89 Comparison of MRI and Molecular Breast Imaging in Breast Diagnostic Evaluation
Breast Cancer
Primary: Sensitivity on the Per Patient Level — 25; 27 participants
Phase 2 N=12 Hybrid Molecular Imaging of ER in Breast Cancer Patients With DCIS
Breast Cancer · Ductal Carcinoma in Situ - Category
Primary: 18F-FES Uptake in DCIS — 1.43 SUV
N/A N=44 FDG Uptake in Vaginal Tampons is Due to Urine
Cancer
Primary: Number of FDG Positive Tampoons — 2; 10 FDG positive tampons
N/A N=969 Molecular Breast Imaging as a Screening Tool for Women With Dense Breasts
Breast Cancer
Primary: Diagnostic Yield — 3.2; 9.6; 10.7 cancers per 1000 women screened — p=.016
N/A N=35 Multi-Center Evaluation of Feasibility of SPECT Measurement of Myocardial Blood Flow and Reserve
Coronary Artery Disease
Primary: Correlation in MBF Between Core Laboratory and Local Site — 0.93 correlation coefficient
Phase 4 N=40 Sentinel Lymph Node Biopsy Findings in Patients With Breast Cancer
Breast Cancer
Primary: Injection Site Clearance for Lymphoseek and 99mTc-Sulfur Colloid (SC). — 1.78; 0.045 minutes
N/A N=4 Anti-3-[18F]FACBC Imaging of Parathyroid Adenomas
Parathyroid Disease
Primary: Detection Rate of Parathyroid Adenomas of Anti-3-[18F]FACBC Modality — 80 percentage of adenomas detected
N/A N=70 Benefit of a Diagnostic MRI in Case of Pathological Nipple Discharge With Normal Mammography / Ultrasound
Breast Cancer
Primary: The Negative Predictive Value (PVV) of MRI
Phase 2 N=114 Combined 18F-NaF/18F-FDG PET/MRI for Detection of Skeletal Metastases
Cancer
Primary: Cohort 1 - NaF PET/CT vs 99mTc-MDP Bone Scintigraphy — 10; 0; 0 Participants
N/A N=298 Diagnostic US for Reduction of Benign Breast Biopsies Using US-guided Optical Tomography
Breast Biopsy
Primary: Impact of US-guided DOT on the Potential Reduction of Benign Biopsies as Measured by Comparing the Reads With a Non- Suspicious Assessment of Conventional Imaging (CI)…
Phase 4 N=219 Quantitative Subharmonic Breast Imaging
Breast Cancer
Primary: Number of Breast Cancer Lesions Characterized as Malignant or Benign With 3D SHI, Harmonic Imaging (HI) or Power Doppler Imaging (PDI) — 69; 24; 126; 58 lesions
Phase 2 N=44 18F-FLT-PET in Breast Cancer (MK-0000-139)
Breast Cancer
Primary: Change From Baseline in 18F-FLT-PET Mean Standardized Uptake Value (SUVmean) After the First Cycle of Standard of Care (SOC) Neo-adjuvant Chemotherapy. — 2.79; 1.78…
N/A N=133 Patterns and Prevalence of FDG Extravasation in PET/CT Scans
Intravenous Infiltration
Primary: Number of Participants With Intraveneous Infiltration of FDG During Routine PET/CT Imaging by Visually Assessment of Interpreting Physicians — 17; 32 Participants
N/A N=72 The Prone to Supine Breast MRI Trial
Breast Cancer
Primary: Number of Successful Segmentation of Supine MRI Images — 54; 61 Participants
N/A N=31 Improved Breast MRI With SWIFT
Breast Cancer
Primary: Lesions — 0; 12 lesions
Phase 2 N=62 Feasibility of One-Step Sentinel Lymph Node (SLN) Biopsy With Radiolabeled Methylene Blue (IND 70,627)
Breast Cancer
Primary: The Number of Participants That Have Sentinel Nodes Which Are Radioactive or Blue, or Radioactive and Blue or Have Efferent Blue Lymphatics Leading up to the Sentinel…
N/A N=102 Comparison of Use of Indocyanine Green and 99mTc-labeled Radiotracer for Axillary Lymphatic Mapping in Patients With Breast Cancer
Stage I Breast Cancer · Stage II Breast Cancer
Primary: Proportion of Sentinel Lymph Nodes (SLNs) Flagged by the Two Methods — 0.86; 0.95 proportion of nodes
Phase 2 N=60 Feasibility Study of Intraoperative Imaging in Breast Cancer
Breast Cancer
Primary: (Phase A Only) Selection of Dose of LUM015 to be Used in Future Breast Trials — 2.1; 4.7; 4.2 Ratio
Phase 1 N=20 Fluciclovine and PSMA PET/CT for the Classification and Improved Staging of Invasive Lobular Breast Cancer
Anatomic Stage IV Breast Cancer AJCC v8 · Invasive Breast Lobular Carcinoma · Metastatic Breast Lobular Carcinoma
Primary: Verified Detection Rate for Metastasis — 5.9; 5.5 SUVMax
Phase 2 N=234 Intraoperative Detection of Residual Cancer in Breast Cancer
Breast Cancer
Primary: Collect Data to Refine and Verify the Tumor Detection Algorithm. — 11.3 Percentage
N/A N=32 Cadmium-zinc-telluride (CZT) Imaging of Myocardial Blood Flow (MBF) (SPECT MBF)
Coronary Heart Disease
Primary: Difference Between Measurements of Myocardial Blood Flow Measured With PET and With SPECT — 0.06 mean residual difference in MBF
N/A N=28 Novel MRI Sequence MR Fingerprinting in Breast MRI Feasibility Study
Breast Screening
Primary: Ratio of Intensity Score of Normal Breast Tissue for Left Breast Tissue Compared to Right for T1 Imaging Sequence — 1.07 ratio
Phase 1 N=15 [F-18] Fluorothymidine (FLT) Imaging on Patients With Primary Brain Tumors
Cancer · Brain Tumors
Primary: Area Under the Receiver Operating Curve (ROC AUC) Values for PET Imaging Techniques — 0.98; 0.91; 0.89; 0.82 Probability
N/A N=30 Imaging Brain Tumors With FACBC and Methionine
Brain Cancer · CNS Cancer
Primary: Maximum Standardized Uptake Value of 3-[18F]-FACBC — 4.5 SUVmax
Phase 3 N=163 Breast and Melanoma Trial With Lymphoseek to Identify Lymph Nodes
Breast Cancer · Melanoma
Primary: Concordance of Blue Dye and Lymphoseek — 1.0000 Proportion of Lymph Nodes