Phase 2 N=101 AVERT Shock: Arginine Vasopressin During the Early Resuscitation of Traumatic Shock
Traumatic Shock
Primary: Number of Blood Products Transfused — 1.7; 3.0 Litre
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 2 N=191 Field Trial of Hypotensive Versus Standard Resuscitation for Hemorrhagic Shock After Trauma
Blunt Trauma · Penetrating Wound · Hemorrhagic Shock
Primary: Total Volume of All Crystalloid Given for Early Resuscitation (Feasibility) — 2.04; 1.04; 1 liters
N/A N=14 Blood Volume Analysis of Total Hip Arthroplasty Patients Under Hypotensive Anesthesia
Blood Volume Analysis
Primary: Change in Total Blood Volume — 487 ml
N/A N=119 Optimal Fluid Resuscitation for Trauma Patients
Trauma
Primary: Mortality — 0 participants
Phase 4 N=17 Descriptive Study of Cardiac Output During Rehydration With Recombinant Human Hyaluronidase in Pediatrics
Dehydration · Cardiac Output · Pediatrics
Primary: Cardiac Output Trends
N/A N=82 Fluid Balance in the ICU - Interventions to Minimize Fluids in Patients With Septic Shock
Septic Shock · Fluid Therapy · Hypotension
Primary: Cumulative Fluid Administered — 4417; 4110 mL of study fluid
Phase 1 N=20 Intravenous AII for the Treatment of Severe Hypotension in High Output Shock: A Pilot Study
Septic Shock
Primary: Standing Dose of Norepinephrine Which is Required to Maintain a Mean Arterial Pressure (MAP) of 65 mmHg - Hour 1 — 7.4; 27.6 mcg/min
N/A N=10 Blood Volume and Fluid Kinetics in Patients Undergoing Extracorporal Circulation
Blood Volume, Extravasation
Primary: Blood Volume — 4.61 Litre
N/A N=1,051 Shock, Whole Blood, and Assessment of TBI S.W.A.T. (LITES TO 2)
Hemorrhagic Shock · Traumatic Brain Injury
Primary: 4 Hour Mortality — 50; 32 Participants
N/A N=76 Ultrasound of the Inferior Vena Cava (IVC) and Dehydration Status in Pediatric Emergency Patients
Dehydration
Primary: Maximum IVC Diameter — 38; 64 mm
Phase 4 N=337 Preventing Cardiovascular collaPse With Administration of Fluid Resuscitation Before Endotracheal Intubation
Acute Respiratory Failure · Intubation Complication
Primary: Number of Participants With Cardiovascular Collapse — 33; 31 Participants
N/A N=50 Effect of Remote Ischemic Conditioning on Trauma Patients With Hemorrhagic Shock
Hemorrhagic Shock
Primary: Neutrophil Oxidative Burst Activity — 302; 302; 298; 268 Median Fluorescence Intensity — p=0.56
Phase 3 N=50 Study of Efficacy & Safety for 3 Infusion Regimens of IV Conivaptan in Subjects With Euvolemic or Hypervolemic Hyponatremia
Hyponatremia
Primary: Change in Serum Sodium From Baseline to the 48 Hour Assessment or Study Drug Discontinuation. — 126.03; 126.39; 125.55; 130.4 mEq/L — p=0.028
N/A N=20 Cardiogenic Shock Intravascular Cooling Trial
Cardiogenic Shock
Primary: Number of Participants With Episodes of Arrhythmia — 0; 1 Participants — p=1
Phase 2 N=50 Resuscitative Endocrinology: Single-dose Clinical Uses for Estrogen-Traumatic Hemorrhagic Shock (RESCUE - Shock)
Hemorrhagic Shock
Primary: Survival — 16; 21 participants — p=.252
Phase 2 N=84 HCT+F vs. HCT Alone in Critically Ill Medical Septic Shock Patients
Septic Shock
Primary: Time to Resolution of Shock — 89; 84 Hours
N/A N=35 The Effect of Hypotensive Anesthesia on Hemoglobin Levels During Total Knee Arthroplasty
Anesthesia
Primary: The Hemoglobin (in g/dl) Levels — 12.2; 12.0; 11.9; 11.8 g/dl
N/A N=5 Biological Response of Trauma Patients to Standard Trauma Resuscitation Therapy
Hemorrhagic Shock
Primary: Biological Response as Characterized by Selected Cytokines, Specifically Tumor Necrosis Factor Alpha (TNFα), Interleukin One (IL-1β), and Interleukin Six (IL-6).
Phase 4 N=1,554 The Conservative vs. Liberal Approach to Fluid Therapy of Septic Shock in Intensive Care Trial
Septic Shock
Primary: 90-day Mortality — 323; 329 Participants
Phase 3 N=258 Hypotonic Versus Isotonic Parenteral (HIP) Fluid Trial
Hyponatremia · Hypernatremia
Primary: Hospital Acquired Acute Plasma Sodium Derangements (Hypo- or Hypernatremia)
N/A N=150 Fluid Responsiveness Evaluation in Sepsis-associated Hypotension
Sepsis · Hypotension
Primary: Fluid Balance — 0.65; 2.02 Liters — p=0.021
N/A N=429 Predict Fluid Responsiveness in Spinal Anesthesia
Hypotension and Shock · Excessive Amount of Blood / Fluid Infusion
Primary: Percentage of Participants With Systemic Hypotensions — 68; 46; 65 Participants
Phase 4 N=121 A Study of Multiple Dosing Regimens of IV Conivaptan in Subjects With Euvolemic or Hypervolemic Hyponatremia
Hyponatremia · Euvolemia · Hypervolemia
Primary: Number and Severity of Infusion Site Reactions (ISRs) Using a Modified ISR Reporting Scale for Phlebitis and Infiltration in Patients Treated With Dose Regimen 1 and…
Phase 3 N=66 Treatment of Post-SCI Hypotension
Spinal Cord Injury · Autonomic Dysreflexia · Orthostatic Hypotension
Primary: Affected Therapy Sessions — 16.4; 10.9 percentage of sessions
Phase 3 N=161 Use of Isotonic Solutions Versus Hypotonic Solutions for Preventing Hospital Acquired Hyponatremia
Hyponatremia
Primary: Hospital Acquired Hyponatremia — 10; 11; 1 participants
Phase 2 N=200 Cold Stored Platelet in Hemorrhagic Shock
Trauma · Hemorrhage
Primary: Study Feasibility — 91; 82 Participants
N/A N=62 Phlebotomy to Prevent Blood Loss in Major Hepatic Resections
Liver Neoplasms · Hepatectomy
Primary: Total Intraoperative Blood Loss, by Measurement of Change in Hemoglobin Levels — 862; 872; 761; 872 mL
N/A N=160 Can Vena Cava Ultrasound Guided Volume Repletion Prevent Spinal Induced Significant Hypotension in Elective Patients?
Fluid Overload · Anesthesia; Adverse Effect, Spinal and Epidural · Regional Anesthesia Morbidity
Primary: Rate of Arterial Hypotension — 42.5; 27.5 percentage of participants
Phase 2 N=40 The Efficacy and Safety of Hypertonic Saline in Cardiac Surgery Patients.
Coronary Artery Disease · Edema
Primary: Extravascular Lung Water Index — 9; 8; 9; 8 mL/kg
N/A N=20 A Net Ultrafiltration Challenge to Predict Preload-dependence (UF CHALLENGE)
Acute Kidney Injury
Primary: Diagnostic Performance of the Net Ultrafiltration (UF NET) Challenge to Detect de Novo Preload Dependence — 0.74 Proportion probability (0 to 1) — p=0.02