Phase 2 N=15 Testing the Feasibility of Patient Controlled Sedation for Ventilated ICU Patients
Acute Respiratory Failure · Anxiety
Primary: Aggregate Sedative Exposure During PCS Use (up to 5 Days). — 4; 3.5 units on a scale
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=15 Acupuncture for Sedation in the Intensive Care Unit (ICU)
Delirium · Respiratory Depression · Overmedication
Primary: Success of Blinding — 1; 1 Participants
Phase 3 N=469 Minimizing ICU Neurological Dysfunction With Dexmedetomidine-induced Sleep
Postoperative Delirium · Sleep · Anesthesia
Primary: Incidence of Delirium — 5; 16 Participants — p=0.029
Phase 3 N=282 Efficacy and Safety of Inhaled Isoflurane Delivered Via the Sedaconda ACD-S Compared to Intravenous Propofol for Sedation of Mechanically Ventilated Intensive Care Unit Adult Patients (INSPiRE-ICU2)
Sedation
Primary: Percentage of Time Sedation Depth is Maintained Within the Target Range, in Absence of Rescue Sedation, as Assessed According to the RASS Scale, in Isoflurane- vs…
Phase 3 N=277 Efficacy and Safety of Inhaled Isoflurane Delivered Via the Sedaconda ACD-S Compared to Intravenous Propofol for Sedation of Mechanically Ventilated Intensive Care Unit Adult Patients (INSPiRE-ICU1)
Sedation
Primary: The Percentage of Time Sedation Depth is Maintained Within the Target Range, in Absence of Rescue Sedation, as Assessed According to the RASS Scale, in Isoflurane- vs…
N/A N=23 Dexmedetomidine Versus Midazolam for Facilitating Extubation
Critical Illness
Primary: Time From Study Drug Initiation to Tracheal Extubation — 2.9; 3.4 days — p=0.8
Phase 3 N=422 The MENDS2 Study, Maximizing the Efficacy of Sedation and Reducing Neurological Dysfunction and Mortality in Septic Patients With Acute Respiratory Failure
Sepsis · Delirium · Impaired Cognition
Primary: Delirium/Coma Free Days (DCFDs) — 8; 7.5 days
N/A N=1,771 The Emergency Department Sedation Pilot Trial
Mechanical Ventilation · Respiratory Failure
Primary: Participant Recruitment — 196; 219 Participants
Phase 4 N=2,367 Randomized Trial of Sedative Choice for Intubation
Acute Respiratory Failure
Primary: All-cause, 28-day, In-hospital Mortality — 330; 345 Participants
N/A N=60 Conscious Sedation for Epilepsy Surgery
Epilepsy
Primary: Patients Satisfaction — 6.33; 6.45 score on a scale
Phase 4 N=50 Dexmedetomidine vs Propofol TIVA (Total Intravenous Anesthesia) and Interscalene Block
Shoulder Pain
Primary: Number of Participants That Need an Airway Intervention. — 0; 5 participants
N/A N=10 Effects of Two Different Sedation Regimes on Auditory Evoked Potentials and Electroencephalogram (EEG)
Conscious Sedation · Deep Sedation · Critical Care
Primary: Amplitudes (in Micro Volts) of Acoustic Event Related Potentials (Time-locked Amplitudes in the Electroencephalogram 100 Milliseconds After the Acoustic Stimulus…
Phase 4 N=50 Alternative Sedation During Bronchoscopy
Sedation
Primary: Decreased Minute Ventilation — 0.736; 0.764 percentage of baseline — p=<0.0001
N/A N=11 Sedation in Patients at Risk for Upper Airway Collapse
Obstructive Sleep Apnea
Primary: Respiratory Disturbance Index — 57.52; 21.32 events per hour
Phase 3 N=94 Effect & Safety of Inhaled Isoflurane vs IV Midazolam for Sedation in Mechanically Ventilated Children 3-17 Years Old
Sedation
Primary: Percentage of Time of Adequately Maintained Sedation Depth up to 48 Hours (± 6 Hours) — 62.37; 68.94 Percentage of time
Phase 4 N=36 Study of Sedative Medications in Patients With Severe Infection and Respiratory Failure
Sepsis · Respiratory Failure · Agitation
Primary: Duration of Mechanical Ventilation — 5; 3 days — p=0.107
Phase 3 N=161 Self-management of Sedative Therapy by Ventilated Patients
Critical Illness · Anxiety · Respiratory Failure
Primary: Anxiety Rating Using the 100mm Vertical Visual Analog Scale — 44.4; 43.4; 40.5; 33.1 score on a scale — p=0.30
Phase 3 N=160 Ketamine / Propofol Admixture "Ketofol" at Induction in the Critically Ill Against Etomidate: KEEP PACE Trial
Critical Illness
Primary: Mean Arterial Pressure — 82.8; 80.9; 81.7; 77.6 mm Hg — p=0.385
Phase 3 N=84 Cerebral Perfusion Pressure Using Precedex and Other Sedatives
Endotracheal Intubation · Continuous IV Sedation · ICP Monitoring
Primary: Variability of Intracranial Pressure (ICP) — 5.66; 5.61 mmHg
Phase 2 N=53 Randomized Controlled Trial of Dexmedetomidine for the Treatment of Intensive Care Unit (ICU) Delirium
Delirium · Agitation
Primary: Resolution of Delirium — 21; 14 Participants
N/A N=90 Remifentanil Versus Dexmedetomidine for Post-Cardiac Surgery Patients With Noninvasive Ventilation Intolerance
Cardiac Surgery
Primary: Number of Participants With NIV Failure — 10; 8 Participants — p=0.831
Phase 4 N=45 Premedication for Non-Emergency Endotracheal Intubation In the NICU
Respiratory Distress Syndrome
Primary: Present the Percentage of Participants With an Excellent Ease of Intubation Rating — 91; 17 % reported as excellent
Phase 4 N=100 Suvorexant and Sleep/Delirium in ICU Patients
Insomnia · Sleep Fragmentation · Sleep Initiation and Maintenance Disorders
Primary: Nighttime Wakefulness After Persistent Sleep Onset (WASO) — 200.7; 184.2 minutes
N/A N=110 Sedline EEG Guided Depth of Anesthesia
Anesthesia · Surgery
Primary: Total Average Anesthetic — 1.1890; 1.2906 percentage of sevoflurane
Phase 4 N=107 Moderate Versus Deep Procedural Sedation With Propofol in the Emergency Department
Pain
Primary: Patients With Clinical Signs of Respiratory Depression or Sub Clinical Respiratory Depressions Measured by Capnography and Pulse Oximetry. — 22; 21 Participants
Phase 3 N=168 Effects of Dexmedetomidine on Delirium Duration of Non-intubated ICU Patients (4D Trial)
Delirium · Agitation
Primary: Duration of Agitation (in Hours), Defined by a RASS ≥ +1 — 1; 2 hours
N/A N=551 Pharmacological Management of Delirium
Delirium · Cognitive Impairment
Primary: Days Free of Delirium and Coma — 4; 5; 4; 5 days
Phase 3 N=100 The Effect of Guanfacine on Delirium in Critically Ill Patients
Delirium
Primary: Days Without Delirium — 2.54; 3.38 delirium free days — p=0.22
Phase 4 N=500 Bispectral Index-guided Sedation for Flexible Bronchoscopy
Flexible Bronchoscopy
Primary: The Number of Participants With Any Hypoxemia Event During Flexible Bronchoscopy — 97; 88 participants — p=0.05
Phase 4 N=798 Ancillary Effects of Dexmedetomidine Sedation After Cardiac Surgery
Heart Disease
Primary: Number of Patients With Atrial Arrhythmia — 121; 134 Participants — p=0.34