Clinical Trial Search

Primary: Percentage of Participants With Residual Neuromuscular Blockade (NMB)(Train of Four [TOF] Ratio <0.9) at Time of Tracheal Extubation — 56 percentage of participants

Primary: Urine Residual in PACU — 219; 222 ml

Primary: Incidence of Postoperative Residual Neuromuscular Blockade at Time of Arrival to the Post-anesthesia Care Unit. — 5 Participants

Primary: Mesure of the Train-of-four (TOF) — 3.8; 4.5; 11.5; 19 minute

Primary: Incidence of Postoperative Residual Neuromuscular Blockade at Time of Extubation — 0 Participants

Primary: Number of Hypoxic Episodes — 1; 0 episode(s)

Primary: The Time Taken to Achieve a TOF Ratio of 0.9 After Administration Sugammadex — 3.13; 2.56; 2.33; 5.00 minutes

Primary: Time Until Complete Reversal of Neuromuscular Blockade — 14.8; 3.5 Minutes

Primary: Breathing Increase Due to a Reduction in Inspired Oxygen Saturation (Hypoxic Ventilatory Response) — 0.66; 0.43; 0.54; 0.34 L/min/% desaturation

Primary: Electric Activity of the Diaphragm (Microvolts) — 3.7; 4.5; 3.2; 2.9 microvolt

Primary: Mean Lowest Saturation — 96.8; 93.3 percentage of oxygen saturation

Primary: Number of Participants With Postoperative Urinary Retention (POUR) of Sugammadex and Neostigmine Groups — 20; 6 Participants

Primary: Percentage of Patients Recovered Cognitively at 1 Week — 91.8; 92.9 percentage of patients recovered

Primary: Time in Minutes to Reach Train of Four (TOF) Ratio ≥ 0.9 After the Administration of Reversal Agent — 8; 3 minutes — p=<0.001

Primary: Time From Start of Administration of Investigational Medicinal Product (IMP, Sugammadex or Placebo) to Recovery of the Fourth Twitch/First Twitch (T4/T1) Ratio to 0.9…

Primary: Residual Neuromuscular Blockade Evidenced by T4/T1 Ratio at the Time of Tracheal Extubation — 1.02; 0.78 T4/T1 Ratio

Primary: Number of Patients With Hypoventilation in Post-anesthesia Care Unit (PACU) — 22; 23 Participants

Primary: Incidence of Residual Neuromuscular Blockade (NMB) as Defined by a Train-of-Four (TOF) Ratio <0.9 at Post Anesthesia Care Unit (PACU) Entry — 0; 33 participants…

Primary: Reversal Time of Rocuronium — 124.9; 171.1 seconds

Primary: Difference in Time of Neuromuscular Recovery From a Neuromuscular Moderate Blockade — 3.9; 26.29 Minutes

Primary: Time to Extubation After End of Procedure — 11.06; 10.36 Minutes

Primary: Incentive Spirometry, Change From Baseline and Recovery Profile - 30 Minutes — -700; -862 mL

Primary: Proportion of Patients Who Have a Clinically Acceptable Surgical Conditions — 0.89; 1 Proportion of patients

Primary: Time From Start of Administration of Sugammadex or Neostigmine to Recovery of the Fourth Twitch/First Twitch (T4/T1) Ratio to 0.9. — 1.62; 26.78; 4.47; 23.43 Minutes

Primary: Hospital Mortality to Day 90 — 288; 289; 213; 216 Participants — p=0.93

Primary: Total Dose of Sugammadex Required to Produce a Train-of-four Ratio of >0.9, Categorized as Greater Than or Less Than the Manufacturers Recommended Dose Based on the…

Primary: Number of Participants Attaining a 5 (Optimal) Surgical Condition Score — 16; 38 Participants

Primary: Time From Start of Administration of Sugammadex or Neostigmine to Recovery of the T4/T1 Ratio to 0.9 After Neuromuscular Block (NMB) Induced by Rocuronium — 3.28; 55.50…

Primary: Peak Airway Pressures — 25.5; 28.3; 28; 30 cm H2O — p=0.01

Primary: BIS Signal Variability Using the Measured Standard Deviation During the Maintenance Phase of Anesthesia — 7.6; 7.8 units on a scale — p=0.651