Phase 4 N=20 Awake Caudal Catheter vs General Anesthesia
Inguinal Hernia
Primary: Number of Participants With Return to Baseline Respiratory Function. — 11; 9 Participants
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 1 N=56 Understanding Dexmedetomidine In Infants Post-Operative From Cardiac Surgery
Hypoplastic Left Heart · Tetralogy of Fallot · Tricuspid Atresia
Primary: PK Profile of Dexmedetomidine — 28 mL/min/(kg^0.75)
Phase 4 N=643 A Multi-site Randomized Controlled Trial Comparing Regional and General Anesthesia for Effects on Neurodevelopmental Outcome and Apnea in Infants
Inguinal Hernia
Primary: Full Scale IQ Score — 100.5; 100.1 score on scale
N/A N=23 Changes in Tissue and Cerebral Oxygenation Following Spinal Anesthesia in Neonates, Infants, and Children
Infants Undergoing Surgery
Primary: Cerebral Non-invasive Near Infrared Spectroscopy (NIRS) — 0.05 percentage change per minute
N/A N=529 Laparotomy vs. Drainage for Infants With Necrotizing Enterocolitis
Infant, Newborn · Infant, Low Birth Weight · Infant, Small for Gestational Age
Primary: Death or Neurodevelopmental Impairment (NDI) — 44; 46; 27; 28 Participants — p=0.03
N/A N=114 Relationship Between Preoperative Anxiety, Postoperative Pain, and Emergence Delirium in Pediatric Surgery
Postoperative Pain · Preoperative Anxiety · Emergence Delirium in Pediatric Anesthesia
Primary: Postoperative Pain Intensity — 1; 1; 3; 1 score
N/A N=24 Sevoflurane Concentrations in Children
Anesthetic · Sevoflurane · Age
Primary: Ratios of the Inspired to Expired Sevoflurane Concentrations During Induction of Anesthesia — 0; 0; 0.684; 0.6615 ratio
N/A N=1,274 An Innovative Tailored Intervention for Improving Children's Postoperative Recovery (WebTIPS)
Anxiety · Pain · Postoperative Behavior
Primary: Assess Children's Domains of Behavior Indicating Anxiety [Activity, Emotional Expressivity, State of Arousal, Vocalization and Use of Parents] — 43.5; 42.3 score on a…
Phase 2 N=30 Stress Response and Neurodevelopmental Outcome After Cardiac Surgery Utilizing CPB in Children: A Prospective, Double Blinded and Randomized Study
Congenital Heart Disease
Primary: Change in Cytokine Levels — 4.38; 4.2; 3.98; 3.85 picograms per milliliter
N/A N=68 Institutional Audit of the Use of Intravenous Acetaminophen in Infants Undergoing Pyloromyotomy
Pyloric Stenosis
Primary: Acetaminophen Dosage — 8.6; 30.7 mg/kg
Phase 4 N=52 Regional Anesthesia Following Pediatric Cardiac Surgery
Atrial Septal Defect · Ventricular Septal Defect · Pain, Procedural
Primary: Total Amount of Opioid Medications Administered — 0.44; 0.83 MME/kg — p=0.001
N/A N=89 The Effect of Anesthesia on Neurodevelopmental Outcome (NDO)
Anesthesia; Adverse Effect · Congenital Heart Disease · Neurodevelopmental Disorders
Primary: Bayley III — 91; 93; 88; 90 score on a scale
Phase 2 N=40 Measuring the Amount of Methadone or Morphine in the Blood of Neonates, Infants & Children After Cardiac Surgery.
Pain
Primary: Maximum Concentration of Morphine Including Its Metabolites (Morphine-3-glucuronide and Morphine-6-glucuronide) — 27.55; 225; 22.95 ng/mL
N/A N=211 Detecting Post-Operative Respiratory Depression in Children
Respiratory Depression
Primary: Abnormal ETCO2 Values, Abnormal Pulse Oximetry Values, and Staff Interventions — 56; 58; 8; 15 participants
N/A N=72 Positive Pressure at Induction of Anesthesia in Children
Continuous Positive Airway Pressure · Hypoxia · General Anesthesia
Primary: Time Between Onset of Apnea and the Drop in 95% Oxyhemoglobin Saturation Levels — 227.65; 133.68 seconds — p=<0.0001
N/A N=25 Delayed Rewarming for Neuroprotection in Infants Following Cardiopulmonary Bypass Surgery
Post-Op Complication
Primary: Infants With Elevated s100b and NSE — 11; 9 Participants
N/A N=989 SPECS: Safe Pediatric Euglycemia in Cardiac Surgery
Heart Defects, Congenital · Hyperglycemia
Primary: Incidence of Nosocomial Infections in the Cardiac ICU — 8.6; 9.9 infections / 1000 pt days
Phase 3 N=51 Ketorolac in Postoperative Infants: Pharmacokinetics and Safety
Postoperative Pain in Infants
Primary: Clearance of S-ketorolac and R+ Ketorolac in 2-6 Month Old Infants Following Surgery — 30.7; 6.5 ml/min
Phase 2 N=51 Measures to Lower the Stress Response in Pediatric Cardiac Surgery
Tetralogy of Fallot (TOF) · Ventricular Septal Defects (VSD) · Atrioventricular Septal Defects (AVSD)
Primary: ACTH and Cytokine Levels — 116.9; 182.7; 135.3; 44.5 pg/mL
Phase 4 N=34 Peri-operative Use of a Pain Injection in Pediatric Patients With Cerebral Palsy
Cerebral Palsy · Hip Dysplasia · Pain, Postoperative
Primary: Opioid Consumption — 0.41; 1.87 mEQ/kg
N/A N=78 Continuous Infusion Versus Bolus Dosing for Pain Control After Pediatric Cardiothoracic Surgery
Congenital Heart Disease
Primary: Total Morphine Dosage — 0.9; 0.23 mg/kg
Phase 2 N=200 Recovery After Total Intravenous Anesthesia With Ketofol Versus Mixture of Ketofol and Lidocaine for Short Pediatric Surgery
Surgical Procedure, Unspecified
Primary: Effect of TIVA With Ketofol and Ketofol Plus Lidocaine on Extubation Time in Children — 240; 120 second
Phase 3 N=1,200 STeroids to REduce Systemic Inflammation After Infant Heart Surgery
Congenital Heart Disease in Children · Inflammatory Response
Primary: Number of Participants at Each Global Rank Endpoint Based Upon Their Most-severe Outcome — 12; 17; 3; 7 Participants — p=0.14
Phase 3 N=137 Decrease Emergence Agitation and Provide Pain Relief for Children Undergoing Tonsillectomy & Adenoidectomy
Obstructive Sleep Apnea
Primary: Emergence Agitation and Pain — 14; 10; 4; 3 units on a scale — p=.001
N/A N=24 Efficacy of Nitric Oxide Administration in Attenuating Ischemia/Reperfusion Injury During Neonatal Cardiopulmonary Bypass
Ischemia/Reperfusion Injury After Neonatal Cardiac Surgery · Inflammatory Reaction After Neonatal Cardiac Surgery
Primary: Change in Biochemical Markers of Ischemia/Reperfusion Injury and Oxidative Damage (Positive ~ Increase From Pre-op) — 0.46; 0.64; 11.52; 26.98 ng/ml — p=>0.05
N/A N=190 Corticosteroid Therapy in Neonates Undergoing Cardiopulmonary Bypass
Congenital Heart Disease · Disorder of Fetus or Newborn
Primary: Number of Participants With a Clinically Derived Composite Morbidity-mortality Outcome — 27; 40 Participants
N/A N=178 Audiovisual Interactive Games to Alleviate Pediatric Perioperative Anxiety
Anxiety
Primary: Patient Anxiety Assessed by Modified Yale Perioperative Anxiety Score (mYPAS) — 5; 21.4; 0.18; 8.9 score on a scale — p=<0.001
Early Phase 1 N=143 Emergence Agitation and Pain Scores in Pediatrics When Comparing Single-modal vs Multi-modal Analgesia for ENT Surgery
Emergence Agitation · Pain
Primary: Emergence Agitation (EA) as Measured by Standardized PAED Scale — 5.3; 4.99; 6.29 score on a scale
N/A N=168 Postoperative Activity Restrictions in Children
Pediatric Post-operative Time to Return to Full Activity
Primary: Post Operative Outcomes - Clinical Complications — 2; 5 Participants
N/A N=61 Percutaneous Rectus Sheath Block Versus Intra-operative Rectus Sheath Block for Pediatric Umbilical Hernia Repair
Pain, Postoperative
Primary: Post Operative Pain Rating — 2.6; 3.3 units on a scale — p=0.11