Phase 4 N=57 Loop Diuretics Administration and Acute Heart Failure
Acute Heart Failure
Primary: Evaluation of Mean Urine Output Volume During the Infusion Period — 2505; 2140 mL — p=0.04
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=974 Isotonic Solution Administration Logistical Testing
Acute Kidney Injury
Primary: Proportion of Isotonic Crystalloid Which is 0.9% Saline — 91.2; 21.0 Percentage of fluid that was saline — p=0.001
Phase 3 N=100 Study of the Safety & Efficacy of Intravenous Acetaminophen in Pediatric Inpatients
Pain · Fever
Primary: Number of Subjects Reporting at Least One Treatment Emergent Adverse Event (TEAE) — 1; 1; 5; 25 Subjects
Phase 3 N=522 A Study of Subcutaneous Versus (vs.) Intravenous Administration of Daratumumab in Participants With Relapsed or Refractory Multiple Myeloma
Multiple Myeloma
Primary: Overall Response Rate (ORR) — 39.4; 43.3 Percentage of participants
Phase 4 N=303 Intravenous Nutrition in Hospitalized Patients: Comparison of Two Oils
Obstruction · Cancer · Ileus
Primary: Prealbumin — 0.15; 0.16 g/l
Phase 3 N=50 Intravenous Fluid Therapy for the Treatment of Emergency Department Patients With Migraine Headache
Migraine Headache
Primary: Verbal Pain Score at 60 Minutes — 4.5; 4.9 units on a scale (0-10)
Phase 3 N=49 Comparison of Intravenous and Subcutaneous Administration of IGIV, 10% in Primary Immunodeficiency (PID) Subjects
Primary Immunodeficiency Diseases (PID)
Primary: Ratio of Area Under the Concentration Curve (AUC 0-τ)/Week Following IV Administration to SC Administration of IGIV, 10% at an Adjusted/Individual Adapted Dose (Part…
Phase 3 N=43 Study of the Safety of Trogarzo™ Administered as an Undiluted "IV Push" or an Intramuscular Injection
HIV-1-infection
Primary: Safety of Trogarzo Given as IV Push Over 30 Seconds — 5; 4; 10 Participants
Phase 1 N=16 Safety of Intravenous Apramycin in Adults
Bacterial Infection
Primary: Area Under the Concentration-time Curve From Time Zero to 8 h (AUC 0-8) of Total Apramycin in Epithelial Lining Fluid (ELF) and Alveolar Macrophage (AM) — 142.8; 131.7…
Phase 3 N=222 A Study of Subcutaneous and Intravenous VELCADE in Patients With Previously Treated Multiple Myeloma
Multiple Myeloma
Primary: Number of Patients With Overall Response (Complete Response + Partial Response) — 61; 31 Participants — p=0.00201
Phase 4 N=120 Preoperative IV Versus Oral Acetaminophen
Pain, Postoperative
Primary: Patient Reported Pain — 4.12; 4.37 score on a scale
Phase 4 N=58 Intravenous Fluids in Benign Headaches Trial
Headache
Primary: Reduction in Pain Scores at 60 Minutes — 48.7; 48.3 reduction in visual analog pain score
Phase 3 N=118 A Study of Intravenously Administered Tamiflu (Oseltamivir) in Patients Over 13 Years of Age With Influenza
Influenza
Primary: Number of Participants With Adverse Events (AEs), Serious Adverse Events(SAEs, AEs Leading to Withdrawal, and Death — 1; 1; 3; 24 Partipants
N/A N=35 Ultrasound-guided Peripheral IJ Study
IV Access
Primary: Number of Participants With Successful Cannulation of the Internal Jugular Vein — 34 Participants
Phase 4 N=23 Intraosseous Vancomycin in Primary Total Hip Arthroplasty - Designing a Protocol
Prosthetic Joint Infection · Vancomycin · Joint Diseases
Primary: Systemic Vancomycin Level - Start of Case — 27.98; 0 ug/mL
Phase 4 N=13 Short-Term Effects & Safety of an Accelerated Intravenous Iron Regimen in Patients With Heart Failure
Heart Failure · Iron Deficiency Anemia
Primary: Serum Hemoglobin Concentration — 1.2 grams per deciliter
Phase 2 N=31 PRO 140 by IV Administration in Adults With HIV-1 Infection
HIV Infections
Primary: Maximum Change in Viral Load Following Initiation of Treatment. — -1.67; -1.83; -0.32 Log10copies HIV-1 RNA/mL
Phase 4 N=214 Efficacy of IV Acetaminophen Versus Oral Acetaminophen
Nephrectomy
Primary: Total Opioid Dose (MME) Used in 24 Hours — 103.61; 109.17 total morphine milligram equivalents — p=0.3938
Phase 4 N=92 Efficacy of High-dose Intravenous Immunoglobulin Therapy for Hyperbilirubinemia Due Rh Hemolytic Disease
Hyperbilirubinemia · Erythroblastosis, Fetal
Primary: Need of Exchange Transfusion — 6; 7 participants — p=0.765
Phase 3 N=213 Safety and Efficacy of Intravenous Acetaminophen (IV APAP) in Adult Inpatients
Acute Pain · Fever
Primary: Number of Subjects Reporting at Least One Treatment-Emergent Adverse Event (TEAE). — 77; 86; 26 Participants
Phase 3 N=105 Safety and Tolerability of Intravenous Brivaracetam (Infusion or Bolus) as Adjunctive Antiepileptic Therapy
Epilepsy
Primary: Number of Subjects With at Least One Treatment-emergent Adverse Event During the Study (Maximum 40 Days) — 20; 19; 21; 20 Participants
N/A N=107 Anaemetro I.V. Infusion 500mg Drug Use Investigation
Anaerobic Infection · Infectious Enterocolitis · Amebic Dysentery
Primary: Number of Participants With Adverse Drug Reaction (ADR) — 7; 1 Participants
Phase 1 N=24 A Study of Diazepam After Intranasal and Intravenous Administration to Healthy Volunteers
Epilepsy
Primary: Comparison of the Absolute Bioavailability of Two Intranasal Diazepam Formulations. — 69; 96.82; 100 Percentage of Bioavailability
Phase 2 N=45 Intravenous (IV) Iron Preparation (VIT-45) in the Treatment of Restless Legs Syndrome (RLS)
Restless Legs Syndrome (RLS)
Primary: International Restless Legs Syndrome (IRLS) Total Score — -8.9; -4.0 Scores on a scale
Phase 4 N=62 Intravenous Sub-dissociative Dose Ketamine Injection Versus Infusion for Analgesia in the Emergency Department
Pain
Primary: Side Effects — 21; 25 Participants
Phase 1 N=12 Pharmacokinetics of Triferic (Ferric Pyrophosphate Citrate) Administered Intravenously to Healthy Adult Volunteers
End Stage Renal Disease
Primary: Pharmacokinetics of Triferic Iron Administered IV to Healthy Adults: Maximum Drug Concentration (Cmax) of Total Serum Iron — 102; 44.1 microgram/deciliter
Phase 1 N=75 Safety and Pharmacokinetic (PK) Study of Intravenous (IV) Acetaminophen Administration in Pediatric Inpatients
Pain · Fever
Primary: Single-dose Maximum Plasma Concentration (Cmax) , Micrograms Per Milliliter (µg/mL) Pharmacokinetics of IV Acetaminophen — 40.1; 20.1; 16.7; 19.3 micrograms per…
Phase 3 N=40 Sub-Q Versus IV Furosemide in Acute Heart Failure
Congestive Heart Failure
Primary: Urine Output — 1636; 1515 mL
N/A N=104 IV Insulin Protocol in Diabetes and Renal Transplantation
Kidney Transplantation · Diabetes · Hyperglycemia
Primary: Delayed Graft Function — 8; 12 participants
Phase 4 N=110 Efficacy of Oral vs. Intravenous Acetaminophen
Postoperative Pain
Primary: Postoperative Pain Score on the Scale of 10 (0=No Pain and 10=Worst Pain) — 2; 2 units on a scale — p=0.252