N/A N=110 Cognition and Psychotherapy in PTSD
Posttraumatic Stress Disorder (PTSD)
Primary: Change in PTSD Checklist (PCL-5) — 9.25; 11.94; 15.91 change in units on a scale
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=122 A Brief Cognitive Task Intervention for NHS Staff Affected by COVID-19 Trauma (GAINS-2 Study)
Intrusive Memories of Traumatic Event(s)
Primary: Number of Intrusive Memories of Traumatic Event(s) — 6.50; 9.0; 11.5; 5.0 Number of intrusive memories
N/A N=102 A Brief GAmeplay Intervention for NHS ICU Staff Affected by COVID-19 Trauma (GAINS Study)
Intrusive Memories of Traumatic Event(s)
Primary: Number of Intrusive Memories of Traumatic Event(s) — 14.5; 14.0; 1.0; 10.0 Number of intrusive memories — p=<= 0.001
N/A N=48 Understanding Trauma Nightmares Using In-Home Measurement
Nightmares · Stress Disorders, Post-Traumatic · Actigraphy
Primary: Actigraphy-derived Sleep Efficiency (SE) Percentage — 74.89; 69.47; 66.67; 71.04 % of time asleep in bed/night
N/A N=54 Rapamycin as a Means of Interference With Reconsolidation of Posttraumatic Stress Disorder-related Traumatic Memory
Posttraumatic Stress Disorder
Primary: Clinician Administered Posttraumatic Stress Disorder Scale (CAPS) — 72.13; 70.63; 58.27; 64.54 scores on a scale — p=>0.05
Phase 4 N=23 A Psychophysiologic Study of Weakening Traumatic Combat Memories With Post-Reactivation Propranolol
Posttraumatic Stress Disorder
Primary: Physiological Posterior Probability of Posttraumatic Stress Disorder (PTSD) as Determined From Psychophysiologic Responses During Script-Driven Traumatic Memory…
Phase 4 N=34 Developing Memory Reconsolidation Blockers as Novel Posttraumatic Stress Disorder (PTSD) Treatments
Post-traumatic Stress Disorder
Primary: Physiological Posttraumatic Stress Disorder (PTSD) Probability as Determined From Psychophysiologic Responses to Traumatic Recollection — 44; 45 percent probability
Phase 2 N=57 Neuromodulation of Trauma Memories in PTSD & Alcohol Dependence
Alcohol Dependence · PTSD
Primary: Retrieval Session Distress Scores (Session 1) — 54.5; 73.9 units on a scale
N/A N=30 Real-time fMRI and Neurofeedback of Brain Networks Mediating Trauma Memory Recall in PTSD
Stress Disorders, Post-Traumatic
Primary: Patient Emotional Response to Volitional Engagement and Disengagement of Emotional Arousal as Measured Using Support Vector Machine Decodings When the Decoding is…
Phase 4 N=41 Suvorexant and Trauma Related Insomnia
Insomnia · Posttraumatic Stress Disorder
Primary: Change in Insomnia Severity Index Score From Baseline. — 6.8; 8.6 units on a scale — p=<.05
N/A N=57 Brief Restructuring Intervention Following Trauma Exposure
Posttraumatic Stress Disorder · Alcohol Use Disorders
Primary: Posttraumatic Stress Disorder Symptom Scale- Interview Version (PSS-I) — 11.4; 22.1 score on a scale
N/A N=31 Information Processing Modification in PTSD (Oct. 18)
Stress Disorders, Post-traumatic
Primary: Post-Traumatic Stress Disorder Checklist-Military Version (PCL-M) — 57.14; 61.33; 52.21; 53.78 units on a scale
Phase 4 N=46 Effects of Delta-9 Tetrahydrocannabinol (THC) on Retention of Memory for Fear Extinction Learning in PTSD: R61 Study
PostTraumatic Stress Disorder
Primary: Brain Measures — 0.039567327; 0.092173636; 0.149446357; -0.021618 arbitrary units — p=< 0.05
N/A N=62 Extinction of Fear Memories With Glucocorticoids in Veterans With PTSD
Posttraumatic Stress Disorder
Primary: PTSD Checklist (PCL). A Self-report, Face Valid Measure of PTSD Symptoms Over a 1 Week Time Period — 55.76; 54.83; 50.14; 51.57 units on a scale
Phase 3 N=36 Exposure Therapy for Chronic PTSD: Efficacy and Mechanisms
Combat Disorders · Posttraumatic Stress Disorder
Primary: Clinician Administered PTSD Scale (Pre & Posttreatment) — 30.0; 53.6 units on a scale
N/A N=88 Post-traumatic Stress Disorder (PTSD) Symptoms in Later Life
Post Traumatic Stress Disorder
Primary: The Trauma History Questionnaire (THQ; Green, 1996) — 5.93; 0.76; 3.81; 0.97 score on a scale
N/A N=37 Meditation in Veterans With PTSD and Mild TBI
Stress Disorders, Post-Traumatic · Concussion, Mild
Primary: Clinician-Administered PTSD Scale (CAPS5)
N/A N=62 Improving Attentional and Cognitive Control in the Psychological Treatment of Intrusive Thoughts
Obsessive-Compulsive Disorder · Generalized Anxiety Disorder · Major Depressive Disorder
Primary: Transdiagnostic Repetitive Negative Thinking (Measured by the Perseverative Thinking Questionnaire [PTQ]) Assessed in Phase I (Pilot Trial) and Group Differences…
N/A N=58 Sleep and Emotional Memory in Peripubertal Anxiety
Anxiety
Primary: Scores on the Lure Generalization Index (a Behavioral Measure of Generalization) — .24; .26; .14; .10 units on a scale — p=<.046
N/A N=29 Expressing Personal Recollections in English or Spanish to Alleviate Traumatic Emotions (Exprésate)
Post Traumatic Stress Disorder
Primary: Change in PTSD Symptoms as Assessed by the Impact of Event Scale — -.383; 6.43; -3.18; -2.11 score on a scale — p=<0.05
N/A N=81 Cognitive Training for PTSD
Posttraumatic Stress Disorder
Primary: Clinician Administered PTSD Scale - Reexperiencing — 2.6; 2.96 score on a scale
Phase 2 N=42 Enhancing Extinction Learning in Post Traumatic Stress Disorder (PTSD)
Chronic Posttraumatic Stress Disorder
Primary: PTSD Symptom Severity-Interview (PSS-I) — 32.07; 31.38; 32.73; 17.10 units on a scale
N/A N=69 Efficacy and Neural Mediators of Response to Trauma Management Therapy for PTSD
PTSD
Primary: Change in Clinician-Administered PTSD Scale for DSM-5 — 38.39; 35.67; 27.15; 29.31 score on a scale — p=0.4154
N/A N=25 DoD PTSD November 13 - Information Processing Modification in the Treatment of PTSD
Stress Disorders, Post-Traumatic
Primary: Post-Traumatic Stress Disorder Checklist-Military Version (PCL-M) — 63.08; 61.71; 42.83; 51.65 units on a scale
Phase 3 N=192 Enhancing Exposure Therapy for Post Traumatic Stress Disorder (PTSD): Virtual Reality and Imaginal Exposure With a Cognitive Enhancer
Post Traumatic Stress Disorder
Primary: CAPS-IV at the End of Treatment — 52.42; 50.61; 54.20; 48.59 units on a scale
N/A N=145 Trauma Informed Guilt Reduction Therapy
Guilt · Shame · Post-traumatic Stress Disorders
Primary: Trauma Related Guilt Inventory - Guilt Severity — 2.5; 2.5; 1.6; 2.2 score on a scale
N/A N=50 Efficacy of Sleep Interventions for Posttraumatic Stress Disorder (PTSD)
Anxiety Disorders · Mood Disorders · Insomnia
Primary: Insomnia Severity Index — 16.4; 16.5; 14.8; 9.3 units on a scale
N/A N=21 Efficacy of a Brief Nightmare Treatment for Veterans
Sleep Disorders · PTSD · Suicide
Primary: Number of Nights With Nightmares — 2.61; .83; 0.97 nights/week
N/A N=30 Top-Down Executive Control in Traumatic Brain Injury (TBI), PTSD and Combined
PTSD · TBI (Traumatic Brain Injury)
Primary: Functional Magnetic Resonance Imaging (fMRI) Correlation — .21; .19; .36 r-value
N/A N=62 Effect of tDCS Timing on Safety Memory in PTSD
PTSD
Primary: Skin Conductance Responses — 0.075; 0.088; 0.057 Skin conductance in microsiemens — p=0.02