Clinical Trial Search

Primary: Change in Maximum Keratometry From Baseline to 6 Months After Treatment — 0.76; 0.97 diopters

Primary: Mean Change From Baseline in Maximum Keratometry (Kmax) — -1.7; 0.6 diopters

Primary: Difference Between Treatment Groups in the Change From Baseline to Month 6 in Kmax — -0.3; 0.6 Diopters — p=0.0004

Primary: Number of Participants With Normal Vision — 8 Participants

Primary: Number of Participants With an Observable Difference Between Virtual Versus Actual Fluorescein Patterns — 0 participants

Primary: Change in LogMAR Corrected Distance Visual Acuity (CDVA) — -0.13; -0.05 LogMAR CDVA — p=0.03

Primary: K-max — -0.52; -0.82 Diopters (D) — p=<0.05

Primary: Mean Change From Baseline in Maximum Keratometry (Kmax) — -0.5; 0.5 diopters

Primary: Time From Surgery to Device Loss or Replacement — 95; 34 median weeks from surgery to removal

Primary: Changes in Corneal Thickness at 1 Millimeter — 730; 760; 700; 720 micrometer

Primary: Patient-Assessed Ocular Itching — 2.2; 2.2; 0.5; 0.5 units on a scale

Primary: Validation of the Theranostic Scores — 91; 95 Percentage

Primary: Change of Corneal Stiffness From Baseline at 6 Months — 0.061 N/mm

Primary: Microbiological Cure on Repeat Culture — 5; 5; 17; 14 Participants

Primary: Central Corneal Endothelial Cell Density (ECD) at Week 12 — 530.86; 468.02; 228.05 cells/mm2 — p=0.0065

Primary: HRT Corneal Scan — 85; 66; 49; 63 cells/mm^3

Primary: Percentage of Patients Achieving Corneal Healing (<0.5 mm2 Lesion Size) of the Persistent Corneal Epithelial Defect at 4 Weeks — 5 Participants

Primary: Incidence of Treatment-Emergent Adverse Events — 0 events

Primary: Determine the Effect of Dexamethasone Intracanalicular Insert on Patients With Keratoconus Who Also Have Allergies — 1.67; 2 papillary grade

Primary: Change in the Keratoconjunctival Staining Score From Baseline — -3.4; -3.1 scores on a scale — p=0.576

Primary: Axial Length — 25.32; 26.08 mm

Primary: Changes in Spherical Equivalent Refraction — 2.31; 2.52 D

Primary: Contact Lens Comfort — 22.03; 9.83 Units on a Scale — p=<0.001

Primary: Central Corneal Swelling — 542.2; 542.4; 544.3 um

Primary: Axial Elongation in the Study and Control Subjects Who Completed the Two Years Study — 0.36; 0.63 mm

Primary: Number of Days to Complete Re-epithelialization — 4.6; 4.1 days to complete re-epithelialization

Primary: Uncorrected Near Visual Acuity 20/32 or Better — 73.8 percentage of subjects

Primary: Correction of Astigmatism — -0.54; -0.59 diopter — p=<0.05

Primary: Ocular Symptoms and Signs Total Composite Score — 29.1; 4.7 units on a scale — p=0.002

Primary: Number of Participants With Complete Healing of Corneal Epithelial Defect at Day 3 — 20; 25 Participants