N/A N=60 Leukocyte Function in Asthma and COPD
Asthma · COPD · Emphysema
Primary: Total Number of Inflammatory Cells Recovered in Sputum — 2.3; 2.1; 1.9; 5.2 10^6 cells/ml — p=0.1
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 2 N=171 Imaging Regional Lung Defect Severity
COPD
Primary: Gas Trapping Measured During Washout of the Perfluorinated Gas Mixture. — 0.718; 0.541; 0.308; 0.451 percentage of total lung volume — p=<0.0001
N/A N=122 Improving Pulmonary Function Following Radiation Therapy
Non-Small Cell Lung Cancer
Primary: Pulmonary Function, Based on Changes in Tissue Elasticity Measured From 4DCT — 1.09; 1.13 ratio
Phase 4 N=88 Lung Function and Patient Preference With QVA149 vs. Tiotropium in COPD Patients
Chronic Obstructive Pulmonary Disease · COPD
Primary: Forced Expiratory Volume in One Second (FEV1) at 1 h Post-inhalation — 1.676; 1.595 Liters — p=0.0017
N/A N=126 The Natural History of Small Airways Physiology in Diseased and Healthy States
Asthma · COPD · Interstitial Lung Disease
Primary: FEV1 — 3.03; 2.32; 3.18; 2.76 L
N/A N=100 Leukocyte Function in Chronic Obstructive Pulmonary Disease (COPD)
COPD · Emphysema · Chronic Bronchitis
Primary: Effective Concentration (EC 50) of GRO Alpha — 1.5; 0.9; 0.6 ng/ml — p=0.05
Phase 4 N=76 Cardiovascular Function in COPD Patients
Pulmonary Disease, Chronic Obstructive
Primary: Change From Baseline in Left Ventricular End Diastolic Volume Index (LVEDVI) in the 6th Week of Treatment — 2.855; 2.317 Millilitre/ meter^2 (mL/m^2) — p=0.6331
Phase 3 N=45 RELOVAIR® Lung Deflation Study
Pulmonary Disease, Chronic Obstructive
Primary: Mean Change From Baseline in Right Ventricular End Diastolic Volume Index (RVEDVI) at the End of the Overall Treatment Period — -0.47; 5.35 Milliliter per meter square…
N/A N=34 Novel Lung Functional Imaging for Personalized Radiotherapy
Lung Cancer
Primary: Grade ≥3 AEs Defined as Definitely, Probably, or Possibly Related to 4D CT Ventilation Image-guided Personalized Radiotherapy — 5 participants
Phase 3 N=38 Hyperpolarized Xenon MRI for Assessment of Pulmonary Function in Lung Resection
Pulmonary Surgical Procedures
Primary: Predicted Percentage of Remaining Pulmonary Function — 73.4; 71.9 percentage of remaining function
N/A N=50 Duration of Continuous Positive Airway Pressure and Pulmonary Function Testing in Preterm Infants
Respiratory Distress Syndrome · Bronchopulmonary Dysplasia
Primary: Changes in the Measurements of Functional Residual Capacity (FRC) in Randomized Premature Infants — 12.6; 6.4; 27.2; 17.1 mL — p=<0.05
N/A N=1,084 Evaluation of Lung Function and Symptoms in Patients Diagnosed With Chronic Obstructive Pulmonary Disease (COPD) on Long-Acting Bronchodilator Monotherapy
Pulmonary Disease, Chronic Obstructive
Primary: Percentage of Participants Whose Post-albuterol Forced Expiratory Volume in One Second (FEV1) Was <80% Predicted Normal — 70; 30 percentage of participants
N/A N=62 Air Pollution Study: The Effect of Ozone on the Lung
Air Pollution
Primary: Concentrations of M1 and M2 Macrophages in the Sputum 24 Hours After Exposure. — 6.823; 1.367 ratio of M2 to M1 macrophages
N/A N=12 SPECT/CT in Measuring Lung Function in Patients With Cancer Undergoing Radiation Therapy
Lung Carcinoma · Malignant Neoplasm
Primary: Spatial Stability of Lung Perfusion and Ventilation Over Time, as Assessed Using 99mTc-MAA SPECT/CT — 0.95 correlation coefficient
Phase 2 N=19 Blood Flow and Vascular Function in Cystic Fibrosis
Cystic Fibrosis
Primary: Acute Study: Percentage Flow-Mediated Dilation (FMD) — 7.8; 7.7; 7.3; 6.6 percent flow mediated dilation
Phase 4 N=70 Stacking Exercises Aid the Decline in FVC and Sick Time
Duchenne Muscular Dystrophy
Primary: Change in FVC (%-Predicted) From Baseline to 2 Years. — -9.2; -6.4 Mean difference in FVC %-predicted — p=0.68
N/A N=134 Longitudinal Follow-up of High School Athletes
Elite Athlete · Healthy
Primary: Maximal Fall in Forced Expiratory Volume in One-second (FEV1) After Eucapnic Voluntary Hyperventilation (EVH) Test — -4; -9; -9; -5 percentage of change in FEV1 after…
N/A N=94 Gas Exchange Kinetics and Work Load During Exercise
Methods of Exercise in Children
Primary: Maximum Oxygen Uptake (VO2) Measurements During Exercise — 1.6; 2.8; 3.2; 1.7 L/min
N/A N=101 Feasibility Study Incorporating Lung Function Imaging Into Radiation Therapy for Lung Cancer Patients
Lung Neoplasms · Lung Cancer
Primary: Radiation Safety (Rate of Grade 2 or Higher (Grade 2+) Radiation Pneumonitis as Defined by the Common Toxicity Criteria for Adverse Effects (CTCAE) Scoring System — 10…
N/A N=14 Effect of Respiratory Exerciser on Pulmonary Functions of COVID-19 Patients
Covid19 · Respiratory Function Loss · Coronavirus Infection
Primary: Change in Peak Expiratory Flow (Absolute Value) — 175; 160 ml/min — p=0.374
N/A N=489 An Observational Outcomes Study for Autologous Cell Therapy Among Patients With COPD and Interstitial Lung Disease
COPD · Interstitial Lung Disease
Primary: Change in Quality of Life (QOL) From Baseline — 35.35; 27.96; 26.87 score on a scale
N/A N=207 Autologous Stem Cell Treatment for Chronic Lung Disease Study
COPD · Interstitial Lung Disease
Primary: Change in FEV1 From Baseline Among COPD Patients — 12.8 percentage of change in FEV1
N/A N=14 Dynamic Respiratory Muscle Function in Late-Onset Pompe Disease
Pompe Disease
Primary: Inspiratory Load Compensation - Inspiratory Volume — 288.41; 554.34; 743.71; 927.57 mL
N/A N=55 Progression of Airway Obstruction in Childhood Asthma
Asthma
Primary: Airway Wall Thickness — 1.5; 1.5; 1.4; 1.6 mm — p=0.2
N/A N=40 Effectiveness of a Preoperative Pulmonary Rehabilitation Program in Patients Awaiting Lung Resection
Lung Cancer
Primary: Exercise Tolerance — 459.7; 341 Seconds
N/A N=51 The Effects of Broccoli Sprout Extract on Obstructive Lung Disease
Asthma · COPD
Primary: The Primary Outcome is the Change in Bronchodilation and Bronchoprotection After Broccoli Sprout Extract — 10.3; 26.7 index
Phase 3 N=72 Study to Assess the Efficacy of Liraglutide in Patients With Type 2 Diabetes Mellitus
Type 2 Diabetes
Primary: Changes From Baseline on Measurements of Respiratory Function Defined by Forced Expiratory Volume in 1 Second (FEV1) — 4.1; 4.3 % (FEV1)
N/A N=252 Chronic Obstructive Pulmonary Disease (COPD) Biomarker Identification Study
COPD
Primary: Spirometry Measurement: Percentage of Predicted Forced Expiratory Volume in 1 Second (FEV1 %Pred) — 75.572; 100.837; 108.311; 111.849 percent of predicted FEV1 — p=<0.0001
N/A N=90 Lung Cancer Exercise Training Study
Lung Cancer
Primary: Changes in VO2peak (on Exercise Capacity) — 17.9; 15.2; 15.2; 14.5 mL/kg/min
Phase 2 N=25 Longitudinal MR Imaging of Pulmonary Function in Patients Receiving Thoracic Radiation Treatment
Radiation Injury
Primary: Change in Pulmonary Function, as Measured by Ventilation Defect Percentage (VDP) — -2.20 Ventilation Defect Percentage (VDP) — p=0.22