Early Phase 1 N=72 Developing a Mobile Method to Measure THC-induced Impairment
Measuring THC-induced Cognitive Impairment Using a Mobile Application
Primary: Simple Reaction Time — .365; .386; .396 Seconds
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 1 N=23 Differences in Cannabis Impairment and Its Measurement Due to Route of Administration
Behavioral Pharmacology of Cannabis
Primary: Tetrahydrocannabinol (THC) Concentration in Blood — 0; 1.78; 3.06; 0 ng/ml
Phase 2 N=199 The Impact and Detection of Driving Impairments Associated With Acute Cannabis Smoking
Cannabis Intoxication
Primary: Change in Composite Drive Score (CDS) From Pre-smoking Simulation — -.09; .12; .01; -.17 z-score — p=<0.001
N/A N=122 An App to Reduce Cannabis Use Among Emerging Adults
Cannabis Use
Primary: App Feasibility — 122 Participants
N/A N=25 Impact of Reduced Cannabis Use on Functional Outcomes
Cannabis · Cannabis Use
Primary: Number of Participants Who Complete the Baseline Assessment — 18 Participants
N/A N=190 Using Imaging to Assess Effects of THC on Brain Activity
Intoxication Alcohol · Intoxication THC · Intoxication Combined Alcohol THC
Primary: Change in Concentration of Oxygenated Hemoglobin Between Pre-drug and Post-drug Scans of Patients Completing the N-back Task. — 0.00000000042; -0.00000000126…
N/A N=201 Cognitive Recovery With Cannabis Abstinence Among High School-Aged Adolescents
Cannabis Use · Cognitive Change · Adolescent Behavior
Primary: Mean Difference in the Total Number of Errors From Paired Associates Learning (PAL) Module Averaged Over Weeks 1, 2, 3, and 4 — 5.6; 6.2; 5.9 score on a scale — p=0.215
Early Phase 1 N=124 Boost Study 21270 (Cognition)
Cognitive Function Abnormal
Primary: Task Completion Rate — 66; 57 Percentage of eligible participants
N/A N=60 Impact of Reduced Cannabis Use on Functional Outcomes (R33 Phase)
Cannabis · Cannabis Use
Primary: Change in Mental Health Symptoms — -0.02; 0.11 score on a scale
N/A N=53 Inhibitory Control Smartphone App
Drinking, Alcohol · Drinking Behavior
Primary: Number of Alcoholic Drinks Intended to Consume if They Were Free (i.e., Intensity) — 6.92; 7.33; 6.71 drinks — p=0.97
Phase 2 N=25 Acute Effects of Cannabis on Cognition and Mobility in Older HIV-infected and HIV-Un-infected Women
HIV · AIDS · Aging
Primary: Change in Acute Effects of Cannabis on Mobility Gait Speed (m/s) — 2.89; 3.11; 2.87; 2.99 m/s — p=0.17
Phase 1 N=10 Marijuana Effects on Simulated Driving Performance
Cannabis · Cannabis Use · Marijuana
Primary: Mean Peak for Standard Deviation in Lane Position (SDLP) — 1.33; 1.37; 1.42; 1.35 centimeters
N/A N=5 Mobile Contingency Management for Marijuana and Tobacco Cessation
Cigarette Smoking · Marijuana Abuse
Primary: Number of Participants Who Self-report Prolonged Abstinence From Smoking — 0 Participants
N/A N=98 Effects of Inhaled Cannabis on Driving Performance
Alcohol Drinking · Cannabis
Primary: Driving Performance — 0.26; 0.42; 0 cm
N/A N=81 Mobile-Based Contingency Management to Promote Daily Self-monitoring in Primary Care Patients
Pain, Chronic
Primary: Number of Daily Self-monitoring Surveys Completed — 23.06; 26.09 Surveys completed
N/A N=253 Pain Research: Innovative Strategies With Marijuana
Chronic Pain · Chronic Low Back Pain · Cannabis Use
Primary: Pain Interference: Roland Morris Disability Questionnaire (RMDQ) — 8.028; 9.635; 9.034; 6.194 score on a scale
Phase 2 N=64 Examining Alcohol Consumption, Perceptions, and User Experience of Alcohol Moderation Strategies
Alcohol Abuse · Alcohol Use Disorder · Alcohol Abuse, Episodic
Primary: The Young Adult Alcohol Consequences Questionnaire — -4.48; -4.63 outcome score minus baseline score
N/A N=99 Cannabis Effects on Driving-related Skills of Young Drivers
Psychomotor Impairment
Primary: Psychomotor Impairment (Driving) — 3.38; -1.54 change in kph
N/A N=408 Alcohol & Mobile Phone Study to Reduce High-risk Alcohol Use and Consequences
Alcohol; Use, Problem
Primary: Daily Drinking Questionnaire - Typical Number of Drinks Per Week — 13.51; 12.23; 10.70; 8.95 drinks — p=0.34
N/A N=44 Reactions of Older Adults Driving After Cannabis Exposure
Chronic Pain
Primary: Simulated Driving Performance Task Measuring Divided Attention — 3.42; 2.57 units on a scale
N/A N=361 Anxiety, Inflammation, Stress, and Cannabinoids
Anxiety · Anxiety Disorders · Anxiety Generalized
Primary: Change in Anxiety: Depression Anxiety Stress Scale (DASS21). — 9.38; 10.1; 10.5; 9.85 units on a scale
Phase 2 N=66 Clinical and Neurobiological Effects of Cannabis Dependence in Young Adults
Cannabis Dependence · Cannabis Withdrawal
Primary: Withdrawal Symptom Severity on the Marijuana Withdrawal Checklist (MWC) at 28 Days Following Single Dose Administration of Rimonabant or Placebo, or Commencement of…
N/A N=53 CanCope: Digital Intervention for Coping With Cannabis Craving
Cannabis Use
Primary: Average Craving Level - Active vs. Control Messages — 4.736; 4.629 score on a scale
Early Phase 1 N=53 Dronabinol Interactions With Cognitive Enhancing Drug in Humans
Cannabis · Marijuana Abuse
Primary: CANTAB:CAmbridge Neuropsychological Test Automated Battery RVIP: Rapid Visual Information Processing — 0.91; 0.9; 0.92; 0.9 units on a scale
N/A N=269 Effect of Medical Marijuana on Neurocognition and Escalation of Use
Pain · Insomnia · Depression
Primary: Mean Difference in Number of Cannabis Use Disorder Symptoms Averaged Over 2, 4, and 12 Weeks — 0.39; 0.12 score on a scale — p=<0.001
N/A N=558 Mobile Health for Alcohol Use Disorders in Clinical Practice
Alcohol Drinking · Telemedicine
Primary: Percentage of Heavy Drinking Days, PHDD — 24.4; 21.4; 21.3 percentage of heavy drinking days — p=0.688
N/A N=79 AAT-App Outpatient Trial
Alcohol Use Disorder (AUD)
Primary: Number of Standard Drinks Consumed Per Week — 38.469; 29.645; 33.199; 28.801 standard drinks (10 grams alcohol) — p=.026
N/A N=80 Mobile Application for Prescription Drug-Abuse Education (MAPDE)
Prescription Drug Abuse (Not Dependent)
Primary: Current Opioid Misuse Measure (COMM) — .72; .71; .62; .63 score on a scale — p=.72
N/A N=20 Evaluating Perceived Fitness to Drive While Intoxicated
Alcohol Drinking · Alcohol Intoxication · Perception, Self
Primary: Participants' Perceived Fitness to Drive Measurement — 6.5; 4.6 units on a scale
Early Phase 1 N=24 Age-Related Effects of THC
Tolerance · Adolescent Behavior · THC
Primary: Change From Baseline in Profile of Mood States (POMS) — 5.75; 12.46; 18.55; 4.08 units on a scale