N/A N=334 Independent Predictors of Mortality in Polytrauma Patients
Multiple Trauma
Primary: Death — 52 participants — p=< 0.001
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=88 An Integrated-Delivery-of-Care Approach to Improve Patient Outcomes, Safety, Well-Being After Orthopaedic Trauma
Musculoskeletal Injury Trauma
Primary: Change From Baseline, at Weeks 2, 6 and 12 on the Patient Reported Outcome Measurement Information System (PROMIS) - Physical Function Between the Groups. — 18.65; 17.6…
N/A N=635 A Policy Relevant US Trauma Care System Pragmatic Trial for PTSD and Comorbidity
Posttraumatic Stress Disorder · Depression · Alcohol-Related Disorders
Primary: Change From Baseline PTSD Checklist- Civilian (PCL-C) Over the Course of the Year After Injury — -1.65; 0.08; -4.02; -1.44 score on a scale
N/A N=5 Biological Response of Trauma Patients to Standard Trauma Resuscitation Therapy
Hemorrhagic Shock
Primary: Biological Response as Characterized by Selected Cytokines, Specifically Tumor Necrosis Factor Alpha (TNFα), Interleukin One (IL-1β), and Interleukin Six (IL-6).
N/A N=1,051 Shock, Whole Blood, and Assessment of TBI S.W.A.T. (LITES TO 2)
Hemorrhagic Shock · Traumatic Brain Injury
Primary: 4 Hour Mortality — 50; 32 Participants
N/A N=121 Trauma Survivors Outcomes and Support Study IV
Posttraumatic Stress Disorder · Depression · Suicide
Primary: Change in Post Traumatic Stress Disorder (PTSD) Symptoms Over the Course of the Six Months After Injury — 47.0; 47.0; 43.9; 43.6 units on a scale — p=0.05
N/A N=40 A Policy Relevant US Trauma Care System Pragmatic Trial for PTSD and Comorbidity Pilot
Posttraumatic Stress Disorder · Depression · Alcohol-Related Disorders
Primary: Change From Baseline PTSD Checklist Civilian (PCL-C) at 1 Month — 1.30; 5.04 score on a scale
N/A N=430 Trauma Medical Home for Older Injured Patients
Injuries
Primary: Change in Self Reported Physical Recovery — 40.42; 39.18 score on a scale
N/A N=171 A Comparative Effectiveness Trial of Optimal Patient-Centered Care
Post Traumatic Concerns · Post Traumatic Stress Disorder · Depression and Suicide Ideation
Primary: Change in Post Traumatic Concerns Over the Course of the Six Months After Injury — 80; 83; 55; 59 Participants — p==0.01
N/A N=120 Adolescent Trauma Recovery and Stress Disorders Collaborative Care (ATRSCC) Model Program Trial
Post-traumatic Stress Disorder · Alcohol Abuse · Alcohol Dependence
Primary: Number of Patients With High Levels of Adolescent PTSD Symptoms — 9; 12; 11; 12 Participants — p=0.71
N/A N=450 IT Enhanced Peer Integrated Collaborative Care for US Trauma Care Systems
PTSD · Physical Injury
Primary: Number of Patients With 1 or More Emergency Department Visits Per Quarter — 225; 225; 90; 79 Participants
N/A N=41 Damage Control for Duodenal and Combined Duodenal-Pancreatic Injuries
Injury of Duodenum · Pancreatic Injury
Primary: Duodenal-related Complications — 13; 11; 8; 19 percentage of subjects
N/A N=95 Heart Rate Variability in Trauma Patients
Trauma
Primary: Base Deficit </= -6 — 12 participants
Phase 4 N=1,561 MAST Trial: Multi-modal Analgesic Strategies in Trauma
Nonspecific Pain Post Traumatic Injury
Primary: Opioid Use Per Day — 48; 34 MME per day
N/A N=120 Neurocognitive Evaluation of Mild Traumatic Brain Injury in the Hospitalized Pediatric Population
Mild Traumatic Brain Injury · Concussion
Primary: The Feasibility of Inpatient Bedside Neurocognitive Testing of Pediatric Patients With Minor Traumatic Brain Injury. — 120 participants
Phase 2 N=31 Traumatic Injury Clinical Trial Evaluating Tranexamic Acid in Children: A Pilot and Feasibility Study
Brain Injuries · Wounds and Injuries · Hemorrhage
Primary: Pediatric Quality of Life Inventory (PedsQL) — 64.9; 60.2; 67.2 Quality of life units * months
N/A N=20 ICG Fluorescence Imaging in Trauma Patients
Trauma Injury
Primary: Percent of Patients That Complete the Protocol — 61.5; 83.3; 0 percentage of completed patients
N/A N=989 Improving Initial Management of the Injured at Ghanaian District and Regional Hospitals With a Trauma Intake Form
Behavior Problem
Primary: Appropriate Use of Key Performance Indicators in Initial Assessment and Management of the Injured at Non-tertiary Hospitals in Ghana — 1807; 1894; 1194; 1787…
Phase 2 N=122 Brain Tissue Oxygen Monitoring in Traumatic Brain Injury (TBI)
Severe Traumatic Brain Injury
Primary: Fraction of Time That Brain Oxygen Levels Are Below the Critical Threshold of 20 mm Hg . — 0.15; 0.44 Proportion
Phase 2 N=50 Resuscitative Endocrinology:Single-dose Clinical Uses for Estrogen-Traumatic Brain Injury
Traumatic Brain Injury
Primary: Percent Passing the Galveston Orientation Amnesia Test (GOAT) Within 28 Days Post Injury — 12; 14 Participants — p=0.99
N/A N=6 Team Based Initiative Support
Traumatic Brain Injury
Primary: Number of Participants Who Reported 5 Themes — 6; 6; 6; 6 participants
N/A N=3 Advanced Visuohaptic Surgical Planning for Trauma Surgery
Maxillofacial Injuries
Primary: Percentage of Deviation From Actual Surgical Outcome During Virtual Repair of Mandibular Fractures, Using the Novel Visuohaptic Computational Platform That Was Developed…
N/A N=20 Endovascular Repair for the Descending Thoracic Aorta
Aorta Thoracic; Traumatic Rupture
Primary: Number of Participants With Major Adverse Events — 0 number of serious adverse events
Phase 3 N=199 Low-Titer O Positive Whole Blood Versus Component Therapy for Emergent Transfusion in Trauma Patients
Hemorrhagic Shock · Acute Blood Loss Anemia · Traumatic Brain Injury
Primary: Packed Red Blood Cells Equivalents Units Transfused (1 Whole Blood Unit Treated as 1 Packed Red Blood Cell Unit and 1 Fresh Frozen Plasma Unit) — 3.8; 5.7 units
N/A N=1,516 Brain Injury Rehabilitation Improving the Transition Experience
Traumatic Brain Injury
Primary: Participation Assessment With Recombined Tools - Objective 17 (PART-O-17) — 1.30; 1.33 units on a scale — p=0.44
Phase 4 N=100 ORthopaedic Trauma Anemia With Conservative Versus Liberal Transfusion
Anemia
Primary: Postoperative Wound Infection (Superficial or Deep) or Other Perioperative Infection — 12; 3 Participants — p=.0122
N/A N=32 Improving Family-Centered Pediatric Trauma Care: The Standard of Care Versus the Virtual Pediatric Trauma Center
Trauma · Injuries
Primary: Consumer Assessment of Healthcare Providers and Systems Child Hospital Survey Communication Subscale — 0.769; 0.775; 0.735; 0.747 score on a scale
N/A N=19 MRI Diffusion Tensor Tractography to Monitor Peripheral Nerve Recovery After Severe Crush or Cut/Repair Nerve Injury
Nerve Injury
Primary: Michigan Hand Questionnaire (MHQ) in TPNI Subjects Post Surgery — 33; 83; 5; 75 score on a scale
N/A N=73 Rapid MRI for Acute Pediatric Head Trauma
Head Trauma · Image, Body
Primary: Sensitivity: Percentage of MRIs Correctly Identifying Clinically Important Intracranial Injury (True Positives) — 70 Percentage of MRIs correctly identifying
N/A N=84 Surgical Stabilization for Rib Fractures
Trauma Chest · Rib Fracture Multiple
Primary: Hospital Length of Stay — 9; 6 days