Clinical Trial Search

Primary: The Percent Change in Bilateral Thigh Lean Mass Density (Grams) as Measured by DEXA Scan Will be Compared Between Baseline and After 5-days of Bed Rest — -3.845; -0.249…

Primary: Percent Change in Forearm Glucose Uptake — -73; 127; -95 Percent change in clamp FGU with immob

Primary: Maximal Oxygen Uptake — 14.5; 15.1 ml/kg/min

Primary: Protein Anabolism — 3.56; 11.8; 3.02 grams — p=<0.05

Primary: Change From Baseline to 24 Week Endpoint in Appendicular Lean Body Mass (aLBM) — 0.303; -0.123 kilograms (kg) — p=<0.001

Primary: Resting and Maximum Plasma Leucine Concentration — 659; 755; 721; 95 micromoles per liter

Primary: The Efficacy of GTx-024 on Total Body Lean Mass. — 1.55; 0.98; 0.02 kg

Primary: Cross-sectional Area (CSA) of Muscle Fibers — 2680; 2377; 2028; 1882 micron squared

Primary: Leg Lean Mass — 0.35; -0.55; -0.80; -0.44 kg — p=<0.01

Primary: Change in Total Lean Mass From Baseline — 322.8; 697.6; 392.4; 548.0 grams lean mass — p=0.45

Primary: Lean Leg Mass — -1.2; -0.9 g

Primary: Skeletal Muscle Capillarization — 0.4; 0.2 capillaries per muscle fiber — p=0.27

Primary: Lean Mass — 403 grams

Primary: Whole-Muscle Protein Synthesis — 0.004; 0.015 %/hr

Primary: Fat Mass — 44.71 Kg

Primary: Muscle Satellite Cells — 3.2; 3.2; 4.0; 3.8 Number of Pax7+ cells/muscle fiber

Primary: HF Muscle Force — 23.9; 30.9 Newtons (N)

Primary: Change in 1-repetition Maximum (RM) Muscle Strength (Leg Press, Paretic Side) — 126.1; 11.3 lbs

Primary: Change From Baseline in Participant Lean Body Mass — 1.26; 0.29 kg

Primary: Blood Inflammatory Marker — 2.6; 1.8; 2.9; 1.7 mg·L^-1

Primary: Thigh Cross Sectional Area — 58.2 centimeters squared

Primary: Change in 400 Meter Gait Walk Speed — 0.01; -0.02 meters/second

Primary: MRI Quadriceps Involved Leg — 43.87; 38.31 AU — p=.03

Primary: Total Body Muscle Mass — 21.8; 20.8; 22.2; 20.8 kg units on a scale

Primary: Correlation Between Knee Flexor Muscle Modified Ashworth Scale and Insulin Resistance — -0.692; 0.23 correlation coefficient — p=0.006

Primary: 1 Repetition Maximum Muscle Strength 1-RM (N) Double Leg Press — 1223; 1256; 1483; 1465 N

Primary: Percent Change in Myofiber Cross Sectional Area (CSA). — -15.1; -13.4 percent change from baseline

Primary: Brachial Artery Vascular Function — 5.1; 3.1; 4.4 percent vasodilation

Primary: Change From Baseline in Total Lean Body Mass Measured by DXA (Dual-energy X-ray Absorptiometry) at Weeks 12 and 24 — 1.066; 1.052; 1.059; 1.009 kg — p=<.0001

Primary: Mixed Muscle Fractional Synthesis Rate (FSR) — 0.061; 0.070; 0.066; 0.070 Fractional Synthesis Rate (pecent/hour)