N/A N=23 Skeletal Muscle Atrophy and Dysfunction Following Total Knee Arthroplasty
Knee Osteoarthristis
Primary: Cross-sectional Area (CSA) of Muscle Fibers — 2680; 2377; 2028; 1882 micron squared
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 2 N=251 Study of Efficacy and Safety of Bimagrumab in Patients After Hip Fracture Surgery
Muscle Wasting (Atrophy) After Hip Fracture Surgery
Primary: Change From Baseline in Total Lean Body Mass Measured by DXA (Dual-energy X-ray Absorptiometry) at Weeks 12 and 24 — 1.066; 1.052; 1.059; 1.009 kg — p=<.0001
N/A N=20 Preventing the Loss of Muscle and Function in Hospitalized Older Adults
Muscular Atrophy
Primary: The Percent Change in Bilateral Thigh Lean Mass Density (Grams) as Measured by DEXA Scan Will be Compared Between Baseline and After 5-days of Bed Rest — -3.845; -0.249…
Phase 2 N=40 Effectiveness of Two Types of Treatment in Restoring Muscle After Hip or Knee Surgery
Hip Fracture · Osteoarthritis · Femur Head Necrosis
Primary: Muscle Protein Synthesis — 1.38; 0.84; 1.42; 1.36 %/d
N/A N=21 Body Weight Supported Treadmill Training Following Hip Fracture
Hip Fracture
Primary: Feasibility - # With > or = 60% Compliance, # Agreeing to Participate, # Returning for 3 Month Follow-up — 14; 10; 6 Participants
Phase 2 N=67 Mechanistic Approach to Preventing Atrophy and Restoring Function in Older Adults
Muscle Atrophy · Quality of Life
Primary: MRI Quadriceps Involved Leg — 43.87; 38.31 AU — p=.03
N/A N=15 Functional Movement Retraining After Hip Replacement
Arthroplasty, Replacement, Hip
Primary: Change in Hip Disability and Osteoarthritis Outcomes Score (HOOS) - Activities of Daily Living Scale — -6.00 units on a scale
N/A N=79 Effects of Bisphosphonates and Nutritional Supplementation After a Hip Fracture
Hip Fracture
Primary: Total Hip Bone Mineral Density (BMD) at Baseline, 6 and 12 Months After Hip Fracture. — -0.008; 0.005; -0.017; -0.012 g/cm^2 — p=0.05
N/A N=60 Fluid and Nutrition in Elective Hip Surgery
Hip Surgery Corrective
Primary: Change in Insulin Sensitivity (Percent) — -43; -38; -51 percent change of insulin sensitivity
N/A N=1,108 Using Alternative Implants for the Surgical Treatment of Hip Fractures (The FAITH Study)
Femoral Neck Fractures
Primary: Revision Surgery — 107; 117 Participants
N/A N=1,495 Comparing Total Hip Arthroplasty and Hemi-Arthroplasty on Secondary Procedures and Quality of Life in Adults With Displaced Hip Fractures
Hip Fractures · Femoral Neck Fractures
Primary: Number of Participants With Revision Surgery — 57; 60 Participants
Phase 2 N=25 Prevention of Skeletal Muscle Adaptations to Traumatic Knee Injury and Surgery
Anterior Cruciate Ligament Reconstruction
Primary: Cross-sectional Area of Skeletal Muscle Fibers (All Fibers) — 2827; 3318; 2206; 2376 micrometer squared — p=<0.05
Phase 3 N=122 Effect of Teriparatide on Hip Fracture Healing
Femur Neck Fracture
Primary: Percentage of Participants With No Revision Surgery at 12 Months After Internal Fixation of a Low-Trauma Femoral Neck Fracture — 87; 86 percentage of participants
N/A N=40 Muscle Regrowth During Physical Rehabilitation and Amino Acid Supplementation
Osteoarthritis
Primary: Stair Time up — 7; 8 seconds
N/A N=95 Identifying Therapeutic Targets of Accelerated Sarcopenia
Sarcopenia · Diabetes Mellitus · Aging
Primary: Leg Lean Mass — 0.35; -0.55; -0.80; -0.44 kg — p=<0.01
N/A N=71 Musculoskeletal Plasticity After Spinal Cord Injury
Spinal Cord Injuries
Primary: Acute Gene Regulation: MSTN — 5.49; 4.76 arbitrary units — p=<0.001
N/A N=17 Piloting Prehabilitation Before Abdominal Surgery
Frailty
Primary: Recruitment Rate — 17 Participants
N/A N=37 Forearm Immobilization, Metabolic Health, and Muscle Loss
Healthy
Primary: Percent Change in Forearm Glucose Uptake — -73; 127; -95 Percent change in clamp FGU with immob
N/A N=204 Vitamin D Levels in Frail Elderly Patients With a Hip Fracture
Hip Fracture · Vitamin D Deficiency
Primary: Number of Participants With Suboptimal and Optimal Levels of Vitamin D (Serum-25(OH)D) — 106; 42; 15; 41 Participants
N/A N=38 Strength Training for Skeletal Muscle Adaptation After Stroke
Stroke
Primary: Change in 1-repetition Maximum (RM) Muscle Strength (Leg Press, Paretic Side) — 126.1; 11.3 lbs
N/A N=80 Surgical Treatment of Hip Fractures Under Peripheral Regional Anesthesia
Hip Fractures
Primary: Success Rate (Supplemental Medication) — 22; 20; 3 Participants
N/A N=53 Mobilizing Evidence Into Action to Improve Outcomes of Vulnerable Seniors
Hip Fractures · Femoral Fractures
Primary: Short Physical Performance Battery — 8.24; 9.08 score on a scale
N/A N=95 Improving Rehabilitation Outcomes After Total Hip Arthroplasty
Total Hip Arthroplasty · Osteoarthritis
Primary: 6 Minute Walk Test (6MW) — 252.4; 207.0 meters
Phase 4 N=104 Comparison of the Efficiency of Femur Nerve Block and Intravenous Analgesia Treatment in Hip Fracture Patients
Hip Fractures · Analgesia · Femoral Nerve
Primary: Pain Score Change — 4; 2 units on a scale
N/A N=33 Novel Intervention to Influence Muscle Plasticity in Veterans
Spinal Cord Injuries
Primary: HF Muscle Force — 23.9; 30.9 Newtons (N)
Phase 2 N=20 Evaluation of rGH Therapy to Prevent Muscle Atrophy in Patients With ACL Tears
Rupture of Anterior Cruciate Ligament
Primary: Normative Isokinetic Knee Extension Strength, Measured in Newton Meters (Nm) at 26 Weeks Post-op — 0.881; 0.681 Nm — p=0.0498
N/A N=37 Exercise to Prevent Muscle Mass and Functional Loss in Elderly Dialysis Patients
Chronic Kidney Disease
Primary: Maximal Oxygen Uptake — 14.5; 15.1 ml/kg/min
Phase 3 N=39 Second Study of the Effect of Teriparatide on Hip Fracture Healing
Femur Neck Fracture
Primary: Percentage of Participants With No Revision Surgery at 12 Months After Internal Fixation of a Low-Trauma Femoral Neck Fracture — 74; 93 Percentage of participants
Phase 2 N=10 Healthy Body, Healthy Bones After Bariatric Surgery Trial
Bariatric Surgery Candidate · Bone Loss · Bone Resorption
Primary: Change in Hip Bone Mineral Density (BMD) — 0; -.03 g/cm2
N/A N=68 Walking Skill Training Program Effects in Patients With Total Hip Arthroplasty
Arthroplasty, Replacement, Hip · Exercise Therapy
Primary: 6 Minutes Walk Test (6MWT) — 513; 462; 535; 483 meters