Clinical Trial Search

Primary: Percentage of Participants With at Least a 2 Line Improvement From Baseline in Uncorrected Near Visual Acuity (UNVA) in the Non-Dominant Eye — 46.7; 70.6; 56.3; 68.8…

Primary: Number of Participants With Confirmation of Failure Criteria — 5; 4; 11; 18 Participants — p=0.72

Primary: Weighted Average Change From Baseline in Mesopic, High Contrast Uncorrected Near Visual Acuity (UNVA) Letters — 1.12; 3.83; 5.26; 5.42 letters correctly read — p=0.0029

Primary: Contact Lens Dry Eye Questionnaire-8 (CLDEQ-8) Score — 14.3; 12.8; 19.0 scores on a scale — p=<0.001

Primary: Best Corrected Visual Acuity — -0.075; -0.080; -0.081; 0.227 logMAR

Primary: Percentage of Participants With a ≥ 3-line Improvement in Near Vision and no Loss ≥ 5 Letters Distance Vision — 48.68; 64.5; 11.49 percentage of participants — p=<0.0001

Primary: Percentage of Participants With a ≥ 3-line Improvement in Near Vision and no Loss ≥ 5 Letters Distance Vision — 57.38; 70.59; 7.85 percentage of participants — p=<0.0001

Primary: Weighted Average Change From Baseline in Uncorrected Near Visual Acuity (UNVA) Letters in the Nondominant Eye — 3.00; 4.96; 7.77; 7.54 letters correctly read — p=0.1663

Primary: Distribution of Change in Spherical Equivalent Refractive Error From Baseline to 3 Years — 6; 3; 11; 8 participants

Primary: Changes in Cycloplegic Autorefraction in One Year. — -0.22; -0.78 Diopters

Primary: Binocular Uncorrected Near (40 cm) Visual Acuity — 0.21; 0.39 logMAR

Primary: Mean Change From Baseline in Binocular Distance Corrected Near Visual Acuity (DCNVA) — 4.1; 4.3; 4.4 EDTRS letters

Primary: Night Myopia — -0.30; -0.32 D

Primary: DCNVA — 8; 1 Participants

Primary: Number of Participants With at Least One Treatment-Related TEAE — 101; 75; 17 Participants

Primary: Percent of Subjects With ≥ 15 Letters of Improvement in Photopic Binocular DCNVA and With < 5 Letters of Loss in Photopic Binocular BCDVA in Nyxol-treated Subjects — 27…

Primary: Central Cycloplegic Refractive Error With Retinoscopy — 1.6; 1.2; 2.8 Diopters

Primary: Binocular Uncorrected Near (40 cm) Visual Acuity. — 0.13 logMAR

Primary: Monocular Mesopic Contrast Sensitivity Without Glare (1.5, 3 Cycles/Degree) — 1.612; 1.582; 1.527; 1.658 log contrast sensitivity units

Primary: Percentage of Participants Gaining 3 Lines or More in Mesopic, High-Contrast, Binocular Distance-Corrected Near Visual Acuity (DCNVA) With No More Than 5-Letter Loss in…

Primary: CLUE Vision — 57.1 units on a scale

Primary: Proportion of Subjects With >=15 Letter Gain Without >=5 Letter Loss in Near Visual Acuity — 49.4; 35.0; 22.7 Percentage of participants — p=<.001

Primary: Objective Accommodative Response (in Diopters) on the Grand Seiko Autorefractor at 2.5 Diopters (40 cm) — 1.20; 1.03 Diopters

Primary: Percent of Subjects With ≥ 15 Letters of Improvement in Photopic Binocular DCNVA — 60.5; 30.0; 45.2; 27.3 percentage of subjects with ≥ 15 letters

Primary: Ocular Comfort Assessment Following Instillation at Baseline and the Day Prior to Each Study Visit — 3.2; 3.3; 2.4; 2.2 units on a scale

Primary: Proportion of Subjects With a >=15 Letter Gain Without a < 5 Letter Loss in Near Visual Acuity — 15; 15; 16 Participants

Primary: Binocular logMAR Visual Acuity — -0.098; -0.043; 0.0797 LogMAR

Primary: Uncorrected Visual Acuity (UCVA) — 0.05; -0.07; 0.15; 0.20 logMAR

Primary: Driving Reaction Time to Hazards (as Measured by Time to Brake, in Seconds) — 1.89; 1.88 seconds

Primary: Distance Visual Acuity — 0.41; 0.41; 0.40; 0.43 logMAR — p=0.92