N/A N=100 Evaluation of a Night Spectacle Correction Concerning an Improvement of Mesopic Vision Quality
Myopia-Night Blindness
Primary: Night Myopia — -0.30; -0.32 D
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 2 N=97 Low-dose Atropine for the Prevention of Myopia Progression in Danish Children
Myopia
Primary: Axial Length at 36 Months — 25.28; 25.25; 25.33 mm
N/A N=45 Effectiveness of Orthokeratology in Myopia Control
Myopia
Primary: Axial Length — 25.32; 26.08 mm
Phase 3 N=118 Correction of Myopia Evaluation Trial 2
Myopia
Primary: Distribution of Change in Spherical Equivalent Refractive Error From Baseline to 3 Years — 6; 3; 11; 8 participants
Phase 3 N=43 A Study to Assess the Impact and Adverse Events of Topical Eyedrops of AGN-190584 on Night-driving Performance in Participants, 40 to 55 Years of Age
Presbyopia
Primary: Overall Composite Driving Z Score Approximately 1 Hour After Study Intervention Instillation — 0.118; -0.121 Z-score — p=0.0006
Phase 3 N=144 Safety and Efficacy of Nyxol (0.75% Phentolamine Ophthalmic Solution) in Subjects With Dim Light Vision Disturbances
Dim Light Vision Disturbances
Primary: Percent of Subjects With 3 Lines mLCVA Improvement in Study Eye — 9; 2 Participants
N/A N=248 Examination of Myopia Progression and Soft Bifocal Contact Lens Myopia Control
Myopia
Primary: The Statistical Correlation Between Three-year Change in Choroidal Thickness and Three-year Change in Axial Length — 0.18 mm axial length — p=<0.001
Phase 2 N=24 Single Dose Study of Phentolamine Mesylate Eye Drops in Patients With Severe Night Vision Disturbances
Decrease in Night Vision · Disturbance; Vision, Loss
Primary: Contrast Sensitivity — 0.6; 0.8; 0.9; 0.7 Patches
N/A N=100 Myopia Assessment of Two Manufacturing Processes
Juvenile Myopia
Primary: Change in Axial Length Progression From Baseline — 0.046; 0.047 mm
N/A N=86 Bifocal Soft Contact Lenses and Their Effect on Myopia Progression in Children and Adolescents.
Myopia · Esophoria · Fixation Disparity
Primary: Changes in Cycloplegic Autorefraction in One Year. — -0.22; -0.78 Diopters
N/A N=15 Blue Blockers at Night and Insomnia Symptoms
Insomnia · Sleep
Primary: Pittsburgh Insomnia Rating Scale-65 (PIRS65) Total Score — 72.64 units on a scale
N/A N=144 An Evaluation of the Effectiveness of Dual Focus Soft Contact Lenses in Slowing Mypoia Progression
Myopia
Primary: Change in Refractive Error Relative to Baseline — -0.18; -0.58 Diopters
N/A N=294 Bifocal Lenses In Nearsighted Kids
Refractive Errors
Primary: Refractive Error Progression — -3.46; -3.32; -2.84 Diopters — p=<0.01
N/A N=71 Topical Application of Low-concentration (0.01%) Atropine on the Human Eye With Fast and Slow Myopia Progression Rate
Myopia
Primary: Annualized Changes in Refractive Error (SER) — -0.70; -0.66 Dioptre/year
N/A N=75 Visual Performance of Soft Contact Lenses With Myopia Control Optics
Visual Acuity
Primary: Binocular Visual Performance (LogMAR) — -0.10; -0.10; -0.07; -0.11 logMAR
Phase 3 N=187 Low-Dose Atropine for Treatment of Myopia
Myopia
Primary: Treatment Group Comparison of Change in Spherical Equivalent Refractive Error. — 0; 0; 1; 0 Participants
N/A N=183 Myopia Control With the Multi-segment Lens
Myopia
Primary: Cycloplegic Refraction Change in SER — -0.93; -0.38 Diopters (D)
Phase 3 N=576 CHAMP: Study of NVK-002 in Children With Myopia
Myopia
Primary: Number of Subjects' Eyes That Show < 0.50 D Myopia Progression (SER, Spherical Equivalent Refraction) at the Month 36 Visit — 79; 106; 61 participants' eyes
N/A N=92 Evaluation of the Efficacy in Decreasing Myopia Progression of the Proposed Ophthalmic Lens Prototypes
Myopia
Primary: Axial Lenght Increase — 0.27; 0.37 mm
N/A N=49 Bifocal & Atropine in Myopia (BAM) Study
Refractive Errors
Primary: Refractive Error Progression — -3.50 Diopter — p=0.70
N/A N=31 The Safety and Effectiveness of Breath-O Lenses
Myopia · Safety Issues
Primary: Corneal Biomechanics in Terms of Corneal Hysteresis and Resistance Factor — 11.12; 11.10; 10.37; 11.20 mmHg
N/A N=152 Controlling Myopia Progression With Soft Contact Lenses
Myopia
Primary: Axial Length (Axial Elongation) — 0.158; 0.144; 0.121; 0.242 millimeter (mm)
Early Phase 1 N=8 Vitamin A Palmitate Supplementation in People With Age-Related Macular Degeneration (and Without Reticular Pseudodrusen) and Delayed Dark Adaptation
AMD
Primary: Change in Dark Adaptation Rod Intercept Time (RIT) From Baseline in the Study Eye at the Treatment Completion Visit (Month 2 for Cohort 1 and Month 1 for Cohort 2)…
Phase 2 N=163 A Study of the Concurrent Use of AGN-190584 and AGN-199201 in Participants With Presbyopia
Presbyopia
Primary: Weighted Average Change From Baseline in Mesopic, High Contrast Uncorrected Near Visual Acuity (UNVA) Letters — 1.12; 3.83; 5.26; 5.42 letters correctly read — p=0.0029
N/A N=84 Accommodative Relief for Uncomfortable Non-Presbyopes
Asthenopia
Primary: Contact Lens Dry Eye Questionnaire-8 (CLDEQ-8) Score — 14.3; 12.8; 19.0 scores on a scale — p=<0.001
Phase 2 N=31 Side Effects of Atropine (SEA) Study
Myopia
Primary: Diameter of the Pupil Measured With a Neuroptix Pupillometer — 4.9; 5.1; 5.9; 5.9 millimeters — p=0.002
N/A N=35 Enhancement of Emmetropization in Highly Hyperopic Infants
Hyperopia
Primary: Central Cycloplegic Refractive Error With Retinoscopy — 1.6; 1.2; 2.8 Diopters
N/A N=137 Controlling Myopia Progression With Soft Contact Lenses
Myopia
Primary: Spherical Equivalent Refraction — -0.326; -0.460; -0.430; -0.898 diopter (D)
Phase 2 N=65 Safety and Efficacy of AGN-199201 and AGN-190584 in Patients With Presbyopia
Presbyopia
Primary: Percentage of Participants With at Least a 2 Line Improvement From Baseline in Uncorrected Near Visual Acuity (UNVA) in the Non-Dominant Eye — 46.7; 70.6; 56.3; 68.8…
Phase 3 N=122 VEGF Trap-Eye in Choroidal Neovascularization Secondary to Pathologic Myopia (mCNV)
Myopia, Pathological
Primary: Mean Change in Best Corrected Visual Acuity (BCVA) as Measured by Early Treatment Diabetic Retinopathy Study (ETDRS) From Baseline to Week 24 - Last Observation Carried…