Phase 2 N=24 Brivaracetam to Reduce Neuropathic Pain in Chronic Spinal Cord Injury
Spinal Cord Injuries
Primary: Brief Pain Inventory, Worst Pain — 8.9; 9.7 score on scale
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 3 N=44 Brivaracetam to Reduce Neuropathic Pain in Chronic SCI: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Spinal Cord Injuries · Neuropathic Pain
Primary: The International Spinal Cord Injury Pain Data Set (ISCIPBDS) (Version 2.0) - Change in Average Worst Neuropathic Pain Intensity — -0.5; -0.5 points
Phase 3 N=220 A 17-Week Trial To Assess Pregabalin For The Treatment Of Nerve Pain Due To Spinal Cord Injury
Neuralgia · Spinal Cord Injuries
Primary: Duration Adjusted Average Change (DAAC) of Mean Pain Score — -1.66; -1.07 score on scale — p=0.0032
N/A N=11 Capsaicin 8% Patch for Spinal Cord Injury Neuropathic Pain
Spinal Cord Injuries · Neuropathic Pain
Primary: Change in Pain Relief With Visual Analog (VAS) Pain Scale — 3.586; 5.494; 4.041; 5.677 score on a scale
Phase 3 N=116 A Study of Cannabis Based Medicine Extracts and Placebo in Patients With Pain Due to Spinal Cord Injury
Pain
Primary: Change From Baseline in Mean Central Neuropathic Pain 11-Point Numerical Rating Scale Scores at the End of Treatment (up to 51 Days). — -0.74; -0.69 units on a scale…
Phase 2 N=25 A Safety, Tolerability and Efficacy Study of V158866 in Central Neuropathic Pain Following Spinal Cord Injury
Neuropathic Pain Due to Spinal Cord Injury
Primary: Mean Pain Intensity (NRS) — 5.93; 5.89 units on a scale — p=0.834
Phase 3 N=65 An Implantable Spinal Cord Stimulation Pain Management System
Chronic Pain · Pain, Intractable · Pain
Primary: Change in Visual Analog Scale (VAS) Score From Baseline to 2 Week Post Initial Fitting. — 35 participants with > 50% VAS improvement
Phase 2 N=26 Clinical Neuropharmacology of Pain in Spinal Cord Injury- Dextromethorphan/Lidocaine Combination Clinical Trial
Central Neuropathic Pain · Allodynia · Spinal Cord Injury
Primary: Percent Change in Peak Pain Intensity — -2.5; -7.9; -11.2; -19.2 percentage change from baseline — p=0.0322
Phase 4 N=27 Evaluation of Initiation Time on the Efficacy of Gabapentin in Treating Neuropathic Pain in SCI
Spinal Cord Injuries · Neuropathic Pain
Primary: Neuropathic Pain — 13.3; 15.6 units on a scale — p=0.67
N/A N=4 Epidural Spinal Cord Stimulation for Sensory Restoration and Phantom Limb Pain in Upper-Limb Amputees
Phantom Limb
Primary: Stimulation Thresholds to a Variety of Stimulus Parameters — 2.13 milliamps
N/A N=86 Pregabalin for the Treatment of Pain After Posterior Spinal Fusions
Lumbar Spinal Fusions
Primary: Patient Controlled Analgesia (PCA) Hydromorphone Usage — 44; 39 mL
Phase 2 N=26 Clinical Neuropharmacology of Pain in Spinal Cord Injury- Dextromethorphan Dose Response Clinical Trial
Central Neuropathic Pain · Allodynia · Spinal Cord Injury
Primary: Mean Pain Intensity (Percent Change From Baseline) — -0.006; -0.018; -0.073; -0.24 Percent change from baseline
N/A N=25 Sensory Testing of Multiple Forms of Spinal Cord Stimulation for Pain
Chronic Pain · Failed Back Surgery Syndrome · Complex Regional Pain Syndromes
Primary: Spinal Cord Stimulation (SCS)-Induced Changes in Temporal Summation (TS) — 3.67; 3.33; 3.67; 3.33 score on a scale — p=0.2375
Phase 3 N=140 Evaluation in the Treatment of Neuropathic Pain Post Breast Surgery
Breast Cancer Patient
Primary: Change in Neuropathic Pain Score at 2 Months (Numeric Rating Scale 0-10) — 4.1; 4.6 units on a scale
Phase 2 N=4 Neuromodulation Techniques After SCI
Spinal Cord Injury
Primary: 10-meter Walking Speed (m/Sec) — 0.165; 0.215; 0.13; 0.13 speed (m/sec)
Phase 3 N=42 Vaporized Cannabis and Spinal Cord Injury Pain
Spinal Cord Injuries · Spinal Cord Diseases
Primary: Number of Participants Achieving a Reduction in Pain Intensity of 30% or More — 18; 26; 35 participants — p=<.05
N/A N=12 Combined Peripheral (BreEStim) and Central Electrical Stimulation (tDCS) for Neuropathic Pain Management - Spinal Cord Injury
Pain Management
Primary: Pain as Assessed by Visual Analogue Scale (VAS) — 6.0; 5.9; 5.4; 5.3 units on a scale
N/A N=8 Peripheral Sensory Input in Central Post Stroke Pain (CPSP)
Central Post Stroke Pain
Primary: Reduction in Spontaneous Pain Intensity After a Peripheral Nerve Block. — 6.5; 0.0 units on a scale
N/A N=15 Changes in Cerebral Blood Flow in Patients Treated With Spinal Cord Stimulation for Low Back and Leg Pain
Pain · Low Back Pain · Leg Pain
Primary: Cerebral Blood Flow and VAS With Optimal Paresthesia Coverage Compared With SCS Off
Phase 3 N=212 Safety and Efficacy of Oral Fampridine-SR for the Treatment of Spasticity Resulting From Spinal Cord Injury
Spinal Cord Injury · Muscle Spasticity
Primary: Double-blind Change From Baseline in Ashworth Score Evaluating Spasticity — -0.19; -0.15 units on a scale
N/A N=13 Effects of Transcutaneous Spinal Direct Current Stimulation in Incomplete Spinal Cord Injury
Incomplete Spinal Cord Injury
Primary: Percent Change in Hmax — 27.85; 8.43; -4.91; 16.20 percent change in Hmax
N/A N=27 Spinal Cord Stimulation in Patients With Post-Laminectomy Syndrome in Testing Phase
Laminectomy · Post-laminectomy Syndrome · Spinal Cord Syndrome
Primary: Comparing Visual Analogue Scale (VAS) — 9.3; 8.6; 5.7; 4.9 score on a scale — p=0.112
N/A N=18 High Rate Spinal Cord Stimulation (SCS) for Chronic Pain
Chronic Pain
Primary: Change in Back Pain Intensity — 20.9; 25.6 Percent Change From Baseline — p=0.74
Phase 4 N=304 Spinal Cord Stimulation for Low Back Pain
Chronic Pain
Primary: Effectiveness of SCS Stimulation in Reducing Back Pain Associated With Failed Back Surgery Syndrome After 12 Months of Use.
N/A N=18 Spinal Cord Stimulation to Augment Activity Based Therapy
Transcutaneous Spinal Stimulation · Walking · Spasticity
Primary: Change in Walking Function - 10m Walk Walking Speed (m/s) — 0.06; 0.16 speed difference in meters per second
Phase 3 N=204 Safety and Efficacy of Oral Fampridine-Sustained Release (SR) for the Treatment of Spasticity Resulting From Spinal Cord Injury
Spinal Cord Injury · Muscle Spasticity
Primary: Double-blind Change From Baseline in Ashworth Score Evaluating Spasticity — -0.28; -0.16 units on a scale
N/A N=40 Optimal Stimulation Programming for Spinal Peripheral Neuromodulation
Chronic Pain
Primary: Numeric Rating Scale (Pain) — 5.2; 5.2; 5.3 units on a scale
N/A N=3 Spinal Cord Stimulation in Spinal Muscular Atrophy
Spinal Muscular Atrophy Type 3 · Spinal Muscular Atrophy Type 4
Primary: Muscle Weakness — 2; 3 Participants
N/A N=17 Palliative Strategies in Spinal Cord Injury (SCI)
Spinal Cord Injury
Primary: Muscle Mass Via Dual-Energy X-ray Absortiometry (DEXA)Scan Data — 6104.45; 6355.3 grams — p=.318
N/A N=8 Effects of Bodily Illusion and tDCS on SCI-related Neuropathic Pain
Neuropathic Pain
Primary: Change in Neuropathic Pain Severity — -7.3; 8.5 score on a scale