Clinical Trial Search

Primary: Pain Intensity — 5.82; 4.92 score on a scale

Primary: Number of Subjects With Daily Headache Who Have Continuous Headache — 18; 27 participants

Primary: Persistent Headache Pain Free at 24 Hours — 26; 19 Participants

Primary: Number of Participants Who Report Moderate or Severe Pain Within 24 Hours of Emergency Department(ED) Discharge — 53; 6; 20 Participants

Primary: Reduction in Headache Intensity — 6; 4; 1; 3 Participants

Primary: Headache Days in Each Treatment Period Month — 7.1; 10.88; 7.05; 9.47 Number of Headache days

Primary: Numerical Rating Scale — 4.1; 4.3 units on a scale

Primary: Change in Headache Relief — 23 percentage of headaches resolved — p=.079

Primary: Change in the Number of Moderate to Severe Headache Days Within a 28 Day Average Period in Six Months Compared to Baseline — 4.4; 4.7 Moderate to severe headache days…

Primary: Change in Headache Days/Month After 4 Years Compared to Baseline — 6.6 headache days/month

Primary: Comparison of the Headache Pain Free Attack Rates at 15 Minutes Following the Treatment — 495; 400; 67; 46 Number of attacks

Primary: Number of Participants With Sustained Headache Relief — 12 Participants

Primary: Presence or Absence of Prophylactic Medication for Headache/Migraine — 166; 227; 18; 48 Participants

Primary: Migraine Days Per Month — -8; -4; -3; -3 migraine days per month

Primary: Proportion of Patients Who Were Discharged Pain Free That Have a Recurrence of Headache Within 48 Hours. — 13; 14 Participants

Primary: Frequency of Moderate or Severe Headache After Emergency Department (ED) Discharge — 31; 29; 42; 44 Participants — p=0.751

Primary: Change From Baseline in the Number of Moderate-to-Severe Headache Days Per Month — -2.5; 2.3; -3.9; 1.2 Days per Month

Primary: Change in Frequency of Migraine Days During the Last 28 Day Interval of the Treatment Period as Compared to the 28 Day Baseline Period. — 4.5 days

Primary: Headache Severity 2 Hours Post Treatment — 2.18; 2.09; 0.85; 1.17 units on a scale

Primary: Visual Analog Scale — 8.3; 8.4; 5.3; 5.3 units on a scale

Primary: Change in Monthly Migraine Days (MMD) From Baseline to the Last 28 Days of Treatment Period. — -5.67; -3.5 days — p=0.4267

Primary: Frequency of Headaches — 10 Participants — p=.101

Primary: Headache Days as Self-reported by Participants — 3.0; 3.3 days

Primary: Placebo-controlled Period: Change From Baseline in the Number of MMDs at Weeks 1 - 4 — -6.85; -3.66 days/month — p=<0.0001

Primary: Average Numeric Pain Score — 5.2; 5.8 score on a scale — p=0.7

Primary: The Percentage of Subjects in the Double-blind Period Who Are Pain Free at 2 Hours After Dosing as Reported by the Subject in the eDiary — 51.0; 30.8 Percentage of…

Primary: Migraine Functional Impairment as Measured by Score on the Headache Impact Test 6 (HIT6) Scale — 59; 56 units on a scale

Primary: A Change in the Frequency of Cluster Headache Attacks Per Week — -2.0; -7.6 CH attacks per week

Primary: Number of Participants With Adverse Events — 110; 85; 79 Participants

Primary: 0-10 Pain Scale on Which 0 = no Pain and 10= the Worst Pain Imaginable — 5.2; 3.8 units on a scale