Phase 4 N=47 Nicotine Replacement Therapy in the Intensive Care Unit
Delirium · Psychomotor Agitation · Substance Withdrawal Syndrome
Primary: 30-day Mortality — 9.5; 7.7 percentage of patients
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 3 N=322 Nicotine Mouth Film for Craving Relief.
Smoking Cessation
Primary: The Change From Pre-dose Post-provocation in Craving Score at 50 Seconds — -14.15; -9.26 mm — p=0.0141
N/A N=80 Low Nicotine Cigarettes Plus Electronic Cigarettes
Tobacco Dependence
Primary: Urinary NNAL (4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol) — 505.6; 459.1; 373.3; 180.5 pg/mg creatinine — p=0.017
N/A N=64 Cigarette and E-cigarette Nicotine Content in an Electronic Tobacco Marketplace (ETM)
Tobacco Use
Primary: Number of Cigarettes Purchased — 154.7; 119.2 average number of cigarettes
N/A N=36 Treatment for Nicotine Addiction in Women
Nicotine Dependence
Primary: Withdrawal Symptoms (MNWS Score) — 13.33; 9.40; 11.95; 13.29 score on a scale — p=0.18
Phase 3 N=52 Highdose Nicotine Patch Therapy for Smokeless Tobacco Use
Smokeless Tobacco Use
Primary: End of Treatment (Week 8) Point Prevalence Abstinence — 11; 6 participants — p=0.05
N/A N=17 Varenicline and Nicotine Interactions in Humans (VA)
Smoking Cessation
Primary: Subjective Responses to Intravenous Nicotine — 23; 38; 51; 14 millimeters — p=<0.05
Phase 2 N=14 Nicotine Vaccination and Nicotinic Receptor Occupancy
Nicotine Dependence
Primary: Mean of the Average Nicotine Binding % at Scan 1 and Scan 2 — 54.9; 49.1 percentage of average nicotine binding — p=<0.05
Early Phase 1 N=34 Nicotine Reinforcement and Aversion in Young Adult Light Smokers
Nicotine Addiction
Primary: DEQ - Pleasurable — 2.14; 2.05; 1.98; 2.37 score on a scale
N/A N=12 Pharmacokinetics of Nicotine Film in Smokers
Smoking Cessation
Primary: Peak Plasma Nicotine Concentrations Following Ingestion of a Single (Phase 1) or Repeated (Phase 2) Doses of Nicotine Film — 5.78; 20.5; 8.71; 8.80 ng/mL
Early Phase 1 N=23 Nicotine Delivery Rate and Its Abuse Potential: Impact of Menthol
Nicotine Dependence
Primary: Peak Changes on Items of the Drug Effects Questionnaire (DEQ) - Stimulatory Effects — 7.03; 37.48; 41.91; 28.22 score on a scale
Phase 2 N=40 Pharmacokinetic Study of 4 mg Nicotine Lozenge.
Smoking Cessation
Primary: Area Under the Curve From Time 0 to t, AUC (0-t) — 89.14; 87.38; 86.60; 91.97 nanograms (ng)*hours (h)/milliliter (mL)
N/A N=36 Palatability of Experimental Cigarettes - Study 2
Smoking
Primary: Change in UrineTotal Nicotine Equivalent (TNE) Between Baseline and Week 1 — -16.2; -7.6; 1.3 nmols/ml
Phase 3 N=270 Nicotine Lozenges for Treatment of Smokeless Tobacco Addiction
Smokeless Tobacco Use
Primary: Prolonged Smokeless Tobacco Abstinence at 3 Months — 65; 41 Participants — p=<0.05
Phase 1 N=200 Oral Tolerability Of Two Nicotine Dosage Forms
Healthy Volunteer Smokers
Primary: Percentage of Participants With Oral Soft Tissue Related Adverse Events at Week 1 — 2.3; 12.6 Percentage
N/A N=56 Medicinal Nicotine for Preventing Cue Induced Craving
Tobacco Use Disorder
Primary: Craving Symptom Severity Score Assessed Via Questionnaire — 0.52; 0.57; 0.31 units on a scale — p=0.25
Phase 4 N=127 Nicotine Patch for Marijuana Withdrawal
Marijuana Dependence
Primary: Profile of Mood Scale Total Negative Affect (Tension + Depression + Anger) — 8.52; 8.096; 5.14; 4.615 units on a scale
N/A N=45 Single-dose Nicotine Pharmacokinetics With a New Oral Nicotine Replacement Product
Tobacco Dependence
Primary: Maximum Plasma Concentration — 3.04; 4.94; 8.63; 6.44 (ng/ml)
Early Phase 1 N=16 Nicotine's Potential Abuse With Menthol
Nicotine Dependence
Primary: Drug Effect Questionnaire - Stimulatory Effects — 39.37; 33.48; 32.35; 33.23 units on a scale — p=0.93
N/A N=98 Medicinal Nicotine for Preventing Stress Induced Craving and Withdrawal Symptoms
Tobacco Use Disorder
Primary: Craving — 5.17; 2.45; -1.05; -1.34 units on a scale
N/A N=25 Nicotine Receptor Levels and Smoking Cessation
Smoking Cessation · Nicotine Addiction
Primary: Acetylcholinergic Nicotine Receptor Availability as Determined by 2FA -PET Brain Imaging. — 17.5; 26.8 Distribution Volume Ratio (Vt/fp) — p=0.037
Phase 4 N=20 Nicotine as an Adjuvant Analgesic for Third Molar Surgery
Dental Crowding
Primary: Pain Reported by Patient — 1.6; 2.9 score on a scale
N/A N=136 Reduced Nicotine Content Cigarettes and Tobacco Switching Behaviors
Tobacco Addiction · Dual Tobacco Use
Primary: Number of Days Using Alternative Products — 14; 26; 20 Number of days
N/A N=213 Very Low Nicotine Content Cigarettes and E-Cigarettes in Promoting Smoking Cessation in Daily and Intermittent Cigarette Smokers
Cigarette Smoking-Related Carcinoma · Tobacco-Related Carcinoma
Primary: Usual Brand Cigarettes Per Day — 15.803; 2.1563; 1.8353; 1.4931 Cigarettes per Day
N/A N=26 Nicotine Flux, a Potentially Powerful Tool for Regulating Nicotine Delivery From Electronic Cigarettes
Nicotine Vaping
Primary: Change in Maximum Arterial Blood Nicotine Delivery (Cmax) — 3.75; 2.48; 8.12; 2.96 ng/ml
Phase 4 N=137 Nicotine Replacement for Smoking Cessation During Pregnancy
Nicotine Dependence · Smoking Cessation
Primary: Number of Participants Who Self Report an Average of Zero Cigarettes Smoked Per Day in Preceding 7 Days — 12; 7 Participants
Phase 2 N=46 Neural Substrates in Nicotine Withdrawal
Tobacco Use Disorder
Primary: Measure of Brain Activity: Blood Oxygen Level Dependent (BOLD) fMRI Signal Change During the "N-back" Working Memory Task (Brain Region: Right Dorsolateral Prefrontal…
N/A N=31 Impact of Exclusive Use of Low Nicotine Cigarettes on Compensatory Smoking
Smoking
Primary: Breath Sample (Expired Carbon Monoxide) — 18.77; 31.07; 25.38; 30.49 parts per million — p=0.92
N/A N=78 Nicotine and Behavior in Adult ADHD
ADHD
Primary: ADHD Symptoms — 71.2; 78.4; 47.4; 55.5 Percent of item endorsement — p=<0.025
Phase 2 N=7 Nicotine Treatment of Cognitive Decline in Down Syndrome
Down Syndrome · Mild Cognitive Impairment
Primary: Tolerability of Nicotine Intervention — 1; 3 Participants