N/A N=164 Extracardiac Complications After Cardiac Surgery
Acute Lung Injury · Sepsis · Infections
Primary: Acute Lung Injury After Cardiac Surgery — 20 participants — p=<0.05
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 3 N=600 Cardiovascular Safety of Xenon in General Anaesthesia, in Patient With Cardiovascular Risk in Non Cardiac Surgery
Elevated Cardiac Risk · Coronary Arteries Disease Risk
Primary: Number of Participants With Myocardial Necrosis (MN) — 57; 54 participants — p=0.0052
N/A N=483 Perioperative Management of Patients With Coronary Stents Undergoing Noncardiac Surgery
Acute Coronary Syndrome · Coronary Stent Occlusion · Surgery
Primary: Major Adverse Cardiac and Cerebrovascular Events (MACCEs) — 63 participants
Phase 4 N=130 Prevention of Atrial Fibrillation Following Noncardiac Thoracic Surgery
Atrial Fibrillation
Primary: Incidence of Atrial Fibrillation Requiring Treatment — 9; 21 participants — p=0.02
N/A N=180 GDT by Cardiac Index Trending Via a Radial Arterial Line in General Surgery
Reduction of Length of Hospitality Stay, Reduction of Perioperative Complications
Primary: Postoperative Complications — 52; 72 numbers of complications
N/A N=80 Nitroglycerin Infusion During Cardiac Surgery
Lactic Acidosis · Blood Glucose, High
Primary: Plasma Lactate Level, Before Incision — 1.1; 1.0 mmol/L — p=0.618
Phase 4 N=67 Sitagliptin in Non-Diabetic Patients Undergoing Cardiac Surgery
Coronary Artery Disease
Primary: Number of Participants With Stress Hyperglycemic Events in the Intensive Care Unit (ICU) — 22; 25 Participants
Phase 4 N=798 Ancillary Effects of Dexmedetomidine Sedation After Cardiac Surgery
Heart Disease
Primary: Number of Patients With Atrial Arrhythmia — 121; 134 Participants — p=0.34
Phase 4 N=314 Effects of Microplegia on Transfusion Rates After Cardiac Surgery
Aortic Valve Disease · Mitral Valve Disease
Primary: Intraoperative and Postoperative Transfusions — 2.43; 2.97; 4.42; 3.50 units of blood per participant — p=0.354
Phase 4 N=70 Pilot - Peri-operative Beta Blockade
Adrenergic Beta-Receptor Blockader · Troponin Levels · Cardiomyopathy, Post-surgical
Primary: Difference in hscTnI Values — 3.4; 2.8 ng/L
Phase 4 N=7,112 The ENIGMA II Trial:Nitrous Oxide Anaesthesia and Cardiac Morbidity After Major Surgery: a Randomised Controlled Trial
Coronary Artery Disease
Primary: The Primary Endpoint is a Composite of Death and Cardiovascular Events (Clinical and Silent MI, Cardiac Failure, Cardiac Arrest, Pulmonary Embolism, and Stroke) Measured…
Phase 2 N=200 Use of Antithrombin in Cardiac Surgery With Cardiopulmonary Bypass
Acquired Antithrombin III Deficiency · Coronary Artery Bypass
Primary: Postoperative ATIII Levels at the ICU Admission — 94.06; 64.70 IU — p=<0.0001
Phase 3 N=201 Risk of Oxygen During Cardiac Surgery Trial
Cardiac Surgery
Primary: Intraoperative Systemic Oxidative Damage — 69; 83 pg/ml
Phase 4 N=291 Chronic Angiotensin Converting Enzyme Inhibitors in Intermediate Risk Surgery
Hypotension on Induction
Primary: Number of Participants With Interoperative Hypotension — 76; 95 Participants — p=0.03
N/A N=1,439 Epidemiology of Severe Peroperative Bleeding During Scheduled Surgery
Surgery · Blood Loss
Primary: Unanticipated Bleeding — 0; 100; 0 percentage of participants
Phase 4 N=60 The Use of Paravertebral Block for Cardiac Surgery
Mitral Valve Insufficiency
Primary: Postoperative Fentanyl — 4.51; 6.14 microgram/kilogram
N/A N=297 Natriuretic Peptides - Predictors of In-hospital and Long-term Major Adverse Cardiac Events After Emergency Surgery?
Surgery
Primary: Occurence of Adverse Cardiac Events — 91 participants
N/A N=80 Lidocaine 5% Patch (Lidoderm) for the Prevention of Acute and Chest Pain Following Robotic Valve Surgery
Perioperative Chest Pain
Primary: Pain Disability Index Score (PDI) at Six Months Following Surgical Procedure — 26; 30; 12; 13 units on a scale — p=0.28
Phase 4 N=100 Effect of Neuromuscular Blockade on Pulmonary Complications in Elective Cardiac Surgery
Neuromuscular Blockade · Postoperative Complications
Primary: Number of Participants With Postoperative Pulmonary Complications — 8; 8 Participants — p=1.00
Phase 3 N=722 Evaluation of N1539 Following Major Surgery
Pain, Post-operative
Primary: Number of Subjects With Adverse Events — 339; 119 Participants
Phase 2 N=48 Does Continued Use of Clopidogrel Into Surgery Cause Increased Perioperative Bleeding?
Clopidogrel
Primary: Bleeding-related Re-hospitalization — 1; 1 participants
Phase 3 N=10,010 PeriOperative ISchemic Evaluation-2 Trial
Cardiovascular Disease
Primary: Composite of All-cause Mortality and Nonfatal MI — 173; 194; 178; 161 participants
N/A N=5,056 Perioperative Hypothermia and Myocardial Injury After Non-cardiac Surgery
Perioperative Care · Surgery--Complications · Hypothermia; Anesthesia
Primary: Number of Participants With a Composite Outcome Consisted of Myocardial Injury After Non-cardiac Surgery (MINS), Non-fatal Cardiac Arrest, and All-cause Mortality — 239…
N/A N=266,499 Polypharmacy and Outcomes After Elective Noncardiac Surgery
Polypharmacy · Surgical Procedure, Operative · Morality
Primary: Mortality — 4356; 1919 Participants
N/A N=40 Intraoperative Echocardiography in Low-Risk CABG Surgery
Heart Diseases · Coronary Artery Disease · Chest Pain
Primary: Enrollment and Randomization Feasibility — 40 Participants
Phase 4 N=647 Multicenter Infection Surveillance Study Following Open Heart Surgery
Surgery · Pneumonia · Surgical Site Infection
Primary: Hospital Acquired Pneumonia — 8; 18 participants
N/A N=446 PCORI-1502-27462 Navigating High Risk Surgery: Empowering Older Adults to Ask Questions That Inform Decisions About Surgical Treatment
Communication
Primary: Patient Engagement in Decision Making Measured by Clinic Visit Transcript Coding for Number of and Types of Questions Raised — 68; 55; 95; 89 Participants — p=0.353
Phase 2 N=49 Anesthetics to Prevent Lung Injury in Cardiac Surgery
Inflammatory Lung Injury · Ischemia-Reperfusion Lung Injury · Postoperative Pulmonary Complications
Primary: Bronchoalveolar Lavage (BAL) Concentration of TNF Alpha (pg/mL) — 0.53; 0.53; 22.06; 102.04 pg/mL
Phase 3 N=2,203 Outcomes Following Myocardial Revascularization: On and Off Cardiopulmonary Bypass
Ischemic Heart Disease
Primary: Short-term End Point — 61; 77 participants
N/A N=251 Efficacy of Post-operative Antibiotic Prophylaxis for Thoracic Surgery Requiring Tube Thoracostomy
Antibiotic Prophylaxis
Primary: Number of Participants Who Experienced At Least One Postoperative Infectious Complication — 13; 8 Participants — p=.26