N/A N=204 Oocyte Cryopreservation Registry (HOPE Registry)
Oocyte Cryopreservation
Primary: Thawing Cycle Level Live Birth Rate — 12.4; 15.0; 13.6 % of oocytes thawed per cycle
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=20 The Role of Cetrotide Acetate in Prevention of Ovarian Hyperstimulation Syndrome (OHSS) in Oocyte Donors
Ovarian Hyperstimulation Syndrome
Primary: Volume of Ascites in the Abdomen is Indicative of the Severity of OHSS — 10 cc (volume of ascites)
N/A N=29 Investigational Oocyte Cryopreservation for Medical and Non Medical Indications
Infertility, Female · Deferred Childbearing
Primary: Fertility Quality of Life Questionnaire Completed After One Year After Oocyte Cryopreservation for Non-medical Reasons — 9 Participants
Phase 3 N=27 Immunogenicity of Repeated Follicle Stimulating Hormone (FSH) Stimulation Cycles
Oocyte Donation
Primary: Number of Patients Producing Anti-FSH Antibodies. — 0 participants
N/A N=11 IVF Hyper-responders: Oocyte Vitrification Compared With Embryo Freezing
Infertility
Primary: Fetal Heart Activity 1 Month Post Embryo Transfer — 0; 4 participants with fetal heart activity
Phase 4 N=23 Maximal Stimulation and Delayed Fertilization for Diminished Ovarian Reserve: a Randomized Pilot Study
Infertility
Primary: Oocytes — 19; 47 oocytes
N/A N=96 Differential Regulation of VEGF, Cadherin, Angiopietin 2 by Trigger Oocyte Maturation With GnRHa vs hCG in Donors
Vascular Endothelial Growth Factor Overexpression
Primary: VEGF Protein and mRNA Levels — 1395; 1069; 1666 pg/ml — p=<0.001
Phase 4 N=48 Double Pick up in Poor Prognosis Women
Fertility Disorders
Primary: Number of MII Oocytes Retrieved Between the Two Arms — 4.1; 3.0 number of oocytes
N/A N=196 Effect of a Multivitamin Supplement With Probiotic (Seidivid Ferty4®) on Oocyte Retrieval and Quality
Reproductive Techniques, Assisted
Primary: Number of Oocytes Retrieved — 24.77; 22.57 oocytes retrieved — p=0.2629
N/A N=352 Endometrial Scratch Effect on Pregnancy Rates in Patients Undergoing Egg-donation IVF
EMBRYO IMPLANTATION
Primary: Positive Pregnancy Test — 112; 113 Participants
Phase 4 N=188 Concomitant Administration of FSH With HCG Improves Oocyte Maturation and Quality Double -Blinded Randomized Trial
Infertility
Primary: Mean Fertilization Proportion (2PN/Oocytes Collected) — 0.63; 0.55 proportion of oocytes fertilized
N/A N=49 Feasibility Study for Development of an Early Test for Ovarian Failure
Healthy · Premature Ovarian Failure
Primary: Follicle Stimulating Hormone Stimulated Serum Inhibin B Levels. — 50.7; 48.8; 96.6; 47.7 participants
N/A N=108 A Sibling Oocyte Study- Comparison of ZyMotTM Microfluidics Device to Density Gradient for Sperm Selection During ICSI
ART
Primary: Percentage of Good Quality Blastocyst Formation — 51.4; 51.7 percentage of embryos
Phase 4 N=442 Predictive Factors for Ovarian Stimulation Using a Fixed Daily Dose of 200 IU Recombinant FSH (Study 142003)(P05696)
Infertility
Primary: Total Number of Oocytes — 12.4; 12.1 Number of oocytes
Phase 3 N=105 Administration of Follicle-stimulating Hormone (FSH) and Low Dose Human Chorionic Gonadotropin (hCG) for Oocyte Maturity While Decreasing hCG Exposure in In Vitro Fertilization (IVF) Cycles
Infertility
Primary: Total Fertilization Proportion (i.e. Total Competent Proportion) — 0.59; 0.65 ratio
N/A N=30 Aspiration of Limited Number of Follicles to Prevent Severe Ovarian Hyperstimulation Syndrome
Infertility
Primary: Number of Participants of Severe Ovarian Hyperstimulation Syndrome — 2; 11 participants
Phase 4 N=30 Continuous Double Ovarian Stimulation.
Fertility Issues
Primary: Total Number of Retrieved Oocytes — 13.33; 11.87 oocytes
Phase 2 N=175 The Use of the Hormone Kisspeptin in 'in Vitro Fertilisation' (IVF) Treatment
Infertility
Primary: Percentage of Oocyte Maturation — 49; 36; 76; 103 percentage of expected oocyte yield — p=<0.05
Phase 2 N=10 Elagolix for Fertility Enhancement Clinical Trial
Endometriosis · Unexplained Infertility
Primary: Number of Live Births — 3; 1 live births
Phase 4 N=71 Co-administration of Low Dose hCG at the Time of GnRH Agonist Trigger or 35 Hours Later for the Prevention of OHSS
Ovarian Hyperstimulation Syndrome
Primary: Ongoing Pregnancy — 15; 19 participants
Phase 1 N=34 Bioequivalence Trial of Liquid Versus Freeze-Dried Pergoveris® in Pituitary Suppressed Healthy Premenopausal Female Subjects
Healthy
Primary: Baseline Corrected Area Under the Concentration-Time Curve From Zero to Last Quantifiable Concentration (AUC 0-t,Adj) for Follicle-Stimulating Hormone (FSH) — 3187.4…
N/A N=190 Cumulative Pregnancy Rate With Lower and Higher Gonadotropin Dose During IVF Among Poor Responders
Infertility · Ovarian Dysfunction
Primary: Cumulative Clinical Pregnancy Rate — 27; 17 Participants
Phase 3 N=397 To Investigate Efficacy and Safety of a Single Injection of Org 36286 for Ovarian Stimulation Using Daily Recombinant FSH as Reference (Ensure)(P05690/MK-8962-001)
Infertility
Primary: Number of Cumulus-oocyte-complexes Retrieved, Per Attempt — 13.3; 10.6 Number of cumulus-oocyte-complexes — p=<0.001
Phase 3 N=1,390 Frozen-thawed Embryo Transfer (FTET) Cycle Follow-up Protocol (P06031)
Infertility
Primary: Percentage of Participants With ≥1 Vital Pregnancy (Cumulative Vital Pregnancy Rate) — 31.1; 33.0 Percentage of Participants
Phase 3 N=348 Efficacy and Safety of FE 999049 in Controlled Ovarian Stimulation in Japanese Women
Infertility
Primary: Number of Oocytes Retrieved — 9.3; 10.5 Oocytes retrieved
Phase 3 N=900 Assessment of Multiple Intrauterine Gestations From Ovarian Stimulation
Pregnancy · Unexplained Infertility
Primary: Multiple Gestation Rate Following Recruitment of Multiple Follicular Development With an AI, as Compared to CC and FSH. — 9; 8; 34 number of multiples
Phase 3 N=372 Multi-centre Study to Compare Efficacy and Safety of AFOLIA and Gonal-f in Women for Assisted Reproductive Treatment
Infertility
Primary: Number of Oocytes Retrieved (Per Protocol Population) — 10.8; 10.6 Number of retrieved oocytes — p=0.0003
Phase 2 N=35 Oophorectomy, Estrogen Therapy and Cardiovascular Disease Risk in Young Women
Cardiovascular Risk Reduction
Primary: Arterial Stiffness — 10.1; 14.8; 6.4; 12.7 mm Hg
N/A N=257 Experience of Pain During Oocyte Retrieval- a Comparison Between Two Aspiration Needles
Infertility
Primary: Visual Analogue Scale — 21.0; 26.0 0-100 mm — p=0.04
Phase 3 N=52 A Prospective Study to Evaluate the Addition of Subcutaneous Recombinant Human-Luteinizing Hormone With Recombinant Human-Follicle Stimulating Hormone on Follicular Development in Women Undergoing Ovarian Stimulation for Assisted Reproductive Technologies
Infertility · Ovarian Stimulation
Primary: Mean Number of Metaphase II Oocytes Per Participant Who Underwent Ovum Pick up for Intra-cytoplasmic Sperm Injection (ICSI) — 9.5 Metaphase II Oocytes