Phase 4 N=14 ABRA Abdominal Closure System in Open Abdomen Management
Open Abdomen
Primary: Primary Closure Rate — 75; 67 % of participants
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Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=283 Open Abdomen Study Comparing ABThera™ Open Abdomen Negative Pressure Therapy System and Barker's Vacuum Packing Technique
Open Abdomen
Primary: Number of Participants With Primary Fascial Closure — 139; 69 Participants — p=0.06
N/A N=18 Vacuum Assisted Therapy in Emergent Contaminated Abdominal Surgeries
Gastrointestinal Injury · Complicated Diverticulitis
Primary: Rate of Surgical Site Infection — 5 Participants
N/A N=39 Damage Control Laparotomy
Other Injury of Other Intra-abdominal Organs, Initial Encounter
Primary: Number of Participants Who Died or Had Major Abdominal Complication (MAC) — 6; 12; 6; 8 Participants
N/A N=124 Modified "Open Intraperitoneal Mesh" Technique of Incisional Ventral Hernia Repair
Incisional Ventral Hernia · Recurrent Ventral Hernia
Primary: Number of Early Postoperative Complications (Wound Infections, Seroma, Hematoma) — 9; 21; 2; 92 participants
N/A N=529 Laparotomy vs. Drainage for Infants With Necrotizing Enterocolitis
Infant, Newborn · Infant, Low Birth Weight · Infant, Small for Gestational Age
Primary: Death or Neurodevelopmental Impairment (NDI) — 44; 46; 27; 28 Participants — p=0.03
N/A N=16 OxyGenesys Dissolved Oxygen Dressing; Abdominoplasty at Northwestern University
Wounds
Primary: Healing in Days. — 13.1; 12.5 days
N/A N=104 Open Complex Ventral Incisional Hernia Repair Using Biosynthetic Material for Midline Fascial Closure Reinforcement
Ventral Incisional Hernia
Primary: Hernia Recurrence Rate — 17.3 % of subjects with recurrent hernia
N/A N=7 Direct Peritoneal Resuscitation Effects in the Damage Control Patient
Traumatic Injury
Primary: Number of Participants With Morbidity — 0; 0 number of participants
N/A N=30 Seprafilm in Open Abdomens: a Study of Wound and Adhesion Characteristics in Trauma Damage Control Patients
Open Abdomen · Abdominal Adhesions · Trauma
Primary: Adhesion Characteristics — 1.06; 1.08; 1.13; 1.08 Scores on a scale
N/A N=70 The neoClose Abdominal Closure vs Carter-Thomason Trial
Surgical Port Site Hernia
Primary: Technical Effectiveness as Assessed by Number of Sutures Required to Complete Closure at the Camera Port Site — 2; 1.84 number of sutures
Phase 2 N=20 Alteplase for Percutaneous Treatment of Loculated Abdominopelvic Abscesses
Abdominal Abscess · Pelvic Abscess
Primary: Percentage of Patients Requiring Surgical Debridement for a Persistent Abscess Within 30 Days Following Initial Drainage — 3; 7 participants
N/A N=4 Efficacy Study to Evaluate Laparoscopic Fascial Closure Device
Hernia, Abdominal
Primary: Count of Participants With Successful Port Site Closure Using Port Close Device — 3 Participants
N/A N=41 Damage Control for Duodenal and Combined Duodenal-Pancreatic Injuries
Injury of Duodenum · Pancreatic Injury
Primary: Duodenal-related Complications — 13; 11; 8; 19 percentage of subjects
N/A N=7 Feasibility of Translumenal Endoscopic Omental Patch Closure of Perforated Viscus
Peptic Ulcer
Primary: Number of Participants Completing Natural Orifice Translumenal Endoscopic Surgical (NOTES) Repair — 2; 1 participants
N/A N=613 Immediate Management of the Patient With Rupture : Open Versus Endovascular Repair
Abdominal Aortic Aneurysm
Primary: Mortality — 111; 112; 133; 130 Participants
N/A N=10 Natural Orifice Transgastric Endoscopic (NOTES) Transgastric Diagnostic Peritoneoscopy With Laparoscopic Assistance
Abdominal Adhesions
Primary: Completion of Diagnostic Peritineoscopy — 8 Participants
N/A N=539 Treatment Study of Vacuum Assisted Closure for Postsurgical Subcutaneous Abdominal Wound Healing Impairments
Wound Healing Disorder · Impaired Wound Healing · Abdominal Wound Healing Disorder
Primary: Time to Complete Wound Closure — 36.1; 39.1 Days
N/A N=31 Device to Assist With Abdominal Access During Laparoscopic Surgery
Laparoscopic Surgery
Primary: Surgeon Satisfaction Survey — 4; 4; 4; 4 score on a scale
N/A N=21 Vacuum-Assisted Dressings (V-AD) in the Management of Open Chest Wounds
Open Chest Wounds
Primary: Duration of Negative Pressure Wound Therapy (NWPT) — 8 Days
N/A N=89 A Study to Evaluate Two Different Surgical Methods for Treatment for Abdominal Wall Diastasis
Abdominal Hernias and Other Abdominal Wall Conditions · Post-operative Pain · Recurrence
Primary: Recurrence of Diastasis One Year Post-operatively That Indicated by CT Scan or Clinical Investigation. — 2; 3; 26 Participants
N/A N=34 Mesh Fixation and Closure of Peritoneum Following Laparoscopic Hernia Repair Using N-butyl Cyanoacrylate
Hernia, Inguinal
Primary: Number of Participants With Safe Fixation of Mesh and Closure of Peritoneum by Clinical Investigation During Hospital Stay and Telephone Interview at Six Weeks…
N/A N=4 Temporary Aortic Occlusion With the Abdominal Tourniquet for Refractory Postpartum Haemorrhage: A Proof-of-Concept Study in a War-Affected Region
Postpartum Haemorrhage (PPH)
Primary: Time to Bleeding Control After AAJT-S Device Application — 2 Minutes
N/A N=10 Post Market Clinical Follow Up Study of Avance Foam Abdominal Dressing Kit in Open Abdomen
Open Abdomen
Primary: To Evaluate the Performance of the Dressing Kit as Part of a Negative Pressure System in Post Market Clinical Follow-up Settings — 4; 3; 2; 1 number of surgeons
N/A N=66 Laparoscopic Peritoneal Lavage vs Laparoscopic Sigmoidectomy in Perforated Acute Diverticulitis: a Multicenter Prospective Observational Study (STELLA Study)
Acute Diverticulitis
Primary: Short-term Morbidity — 8; 1 Participants
Phase 3 N=56 Early Short-term Antibiotic Therapy in Penetrating Abdominal Trauma, 3 vs 7 Days
SURGICAL SITE INFECTION
Primary: Surgical Site Infection — 6; 3 participants — p=<0.05
N/A N=35 Feasibility Study of The Use of FLEX HD® Surgical Implant or STRATTICE® Reconstructive Tissue Matrix in The Closure of Abdominal Wall Defects With Component Separation in Clean or Contaminated Cases
Hernia Repair With Compartment Syndrome
Primary: Hernia Recurrence — 11; 12 percentage of patients
N/A N=75 Xen Matrix™ AB Surgical Graft in Ventral or Incisional Midline Hernias
Incisional Hernia
Primary: Number of Participants With Wound Occurrences Up to 45 Days Post Implantation — 11 Participants
N/A N=278 Post-operative Patient Positioning Device for Improvement of Post-Operative Pain
Pain, Postoperative
Primary: Total Morphine Milliequivalent (MME) Use Postoperatively After Cesarean Delivery — 52; 68 Morphine milligram equivalents
N/A N=81 Negative Pressure Wound Therapy in Obese Gynecologic Oncology Patients
Postoperative Complications · Obesity · Gynecologic Neoplasms
Primary: Number of Participants Who Experience Wound Complications (Wound Dehiscence or Infection) — 25; 33; 12; 9 Participants — p=0.27