N/A N=22 Study on the Development of Opioid Induced Hyperalgesia (OIH) After Exposure to Alfentanil
Hyperalgesia
Primary: Pain Tolerance — 105.3; 19.2 seconds
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=27 The Effects of Minocycline in Opioid-maintained Patients
Opioid Dependence · Pain
Primary: Pain Threshold — 18.72; 24.78; 16.16; 24.37 seconds
N/A N=113 Perioperative Opioid-induced Hyperalgesia and Its Prevention With Ketamine and Methadone
Post Operative Pain · Hyperalgesia
Primary: the Extent of Hyperalgesia Area Proximal to Surgical Wound — 19.5; 14.68; 15.28; 11.04 cm
N/A N=79 Effect of Ketamine on Opioid-Induced Hyperalgesia
Pain · Chronic Pain · Hyperalgesia
Primary: Change in Temperature of Pain Threshold — -0.02; -0.61; -0.61; -0.77 Degrees Celsius — p=0.274
Phase 2 N=26 Hyperalgesia in Methadone-Maintained Patients: Can it be Treated?
Opioid-Induced Hyperalgesia
Primary: Change in Pain Threshold Time From Baseline to Week 5 — 2.95; -3.49 seconds
N/A N=93 Reduced Opioid Analgesic Requirements Via Improved Endogenous Opioid Function
Chronic Pain
Primary: Mean of the Change in Morphine Dosage (in mg) Required to Achieve 25% Reduction in Thermal Evoked Pain Responses Relative to Baseline (Pre-intervention) Placebo…
N/A N=7 Opioid Taper Study
Chronic Pain
Primary: Pain Perception Measured Using the Cold-pressor Test (CPT) — 24.01; 42.02 seconds
Phase 2 N=39 Intraoperative Nitrous Oxide and Postoperative Pain for Patients With Current Opioid Treatment
Chronic Pain
Primary: Post-operative Morphine Consumption — 54.6; 44.8 mg — p=0.5
N/A N=56 Study of Pain Processing in Subjects Suffering From Obstructive Sleep Apnea
Sleep Apnea, Obstructive
Primary: Experimental Cold-induced Pain - IGFBP-1 — 0.0025 [sec/(mcg/mL)] /pg/mL — p=<0.05
Phase 4 N=20 The Effect of Intranasal Oxytocin on Pain Sensitivity and Threshold
Healthy
Primary: Hot and Cold Thermal Sensory Threshold for Pain at Baseline in Degrees Celsius. — 43.93; 43.0; 14.81; 13.33 degrees Celsius — p=.47
N/A N=9 Aprepitant Effects on Oxycodone Response
Narcotic Abuse
Primary: Abuse Liability Proxy — 0.197; 0.483; 0.159; 7.678 units on a scale (points 0-100) — p=<.05
N/A N=94 Opioid Sparing Potential of Light-Induced Analgesia
Pain
Primary: Change in Pain Level — 1.15; -0.04; 1.07 score on a scale
N/A N=180 Effect of Butorphanol Combined With Flurbiprofen Axetil on Preventing Hyperalgesia Induced by Remifentanil in Patients
Pain · Anesthesia
Primary: Mechanical Hyperalgesia Threshold on the Dominant Inner Forearm — 60.57; 78.29; 68.50; 79.7 g
N/A N=29 Signs and Symptoms of Opioid-associated Iatrogenic Withdrawal in Critically Ill Adults
Substance Withdrawal Syndrome
Primary: Description of Signs and Symptoms of OIWS in Patients Who Scored Positive for Withdrawal Syndrome (OIWS) According to Diagnostic and Statistical Manual of Mental…
Phase 3 N=288 Placebo-controlled Trial With OROS Hydromorphone Hydrochloride to Treat Patients With Moderate to Severe Pain Induced by Osteoarthritis of the Hip or the Knee
Pain · Osteoarthritis, Hip · Osteoarthritis, Knee
Primary: Analgesic Effect as Assessed by Brief Pain Inventory (BPI) Item 5 Score (Pain on Average) — 6.4; 6.4; 6.5; 6.6 units on a scale — p=0.1212
Phase 2 N=10 Study on the Effect of a Beta Blocker on Increased Sensitivity to Pain in Humans Caused by Opioids
Hyperalgesia
Primary: Percent Change From Baseline in Size (Area) of Secondary Hyperalgesia After Cessation of Remifentanil Infusion, a Measure of Opioid-induced Hyperalgesia (OIH). — -28…
Phase 2 N=51 Prescription Opioid Abuse Among Pain Patients: Predictors of Relapse
Opioid Dependence
Primary: Number of Participants Retained in Study — 18 participants
N/A N=237 Heritability of Opioid Effects: A Twin Study
Pain
Primary: Heat Pain Threshold — 49.6; 48.6 degrees centigrade
Phase 4 N=54 Low Dose Ketamine Study on Opioid Tolerance and Hyperalgesia
Idiopathic Scoliosis · Spondylolisthesis
Primary: Morphine Equivalent Consumption (mg/kg) — 1.3; 1.36; 1.28; 1.275 mg/kg
Phase 1 N=9 Opioid Antagonism in Hypogonadotropic Hypogonadism
Hypogonadotropic Hypogonadism · Low Testosterone
Primary: Average Change in Mean Luteinizing Hormone (LH) Value — 1.571 IU/L
Phase 2 N=84 Effects of Testosterone Replacement on Pain Sensitivity and Pain Perception
Pain · Hypogonadism
Primary: Brief Pain Inventory (BPI) at Week 14 — 10.2; 9.7; 5.3; 5.1 units on a scale
Phase 4 N=172 Opioid Analgesia for MAB
MAB · Pain
Primary: Overall Maximum Self-reported Pain Score — 8; 8 units on a scale
N/A N=133 5HT3 Antagonists to Treat Opioid Withdrawal and to Prevent the Progression of Physical Dependence
Opioid Withdrawal · Physical Dependence
Primary: Change in Objective Opioid Withdrawal Score (OOWS) From Baseline (Prevention of Opioid Withdrawal) — 3.6; 3.6 units on a scale — p=0.87
N/A N=15 Functional Magnetic Resonance Imaging of Opioid Withdrawal in Healthy Human Volunteers
Substance-Related Disorders
Primary: Brain Regions With Increases or Decreases in Amplitude of Low Frequency Fluctuations (ALFF) Associated With Ondansetron Administration — 0.519; 0.562; 0.478; 0.486…
Phase 4 N=180 Minimal Opioid Use After Total Hip Replacement (THR)
Osteoarthritis, Hip
Primary: Opioid Use — 30; 22.5; 15 Oral Morphine Equivalent (mg)
N/A N=100 Perioperative Pain Management In Spine Surgery Patients: Part I
Pain
Primary: Immediate Postoperative Pain Control — 6.6; 6.8 score on a scale
Phase 3 N=343 A Double-blind Study of Controlled Release OROS Hydromorphone Compared to Placebo in Patients With Chronic Osteoarthritis (OA) Pain
Chronic Pain
Primary: Patient Diary-derived Numeric Rating Scale (NRS) Pain Intensity Change From Baseline to Week 12 or Final Visit of the Double-blind Phase — 0.6; 0.6 units on a scale
Phase 3 N=260 An Efficacy and Safety Study of Oral Osmotic Therapeutic System (OROS) Hydromorphone Hydrochloride (HCl) in Participants With Cancer Related Pain
Pain
Primary: Change From Baseline in Worst Pain in the Past 24 Hours Assessed by Brief Pain Inventory (BPI) Short Form Questionnaire Score at Day 29 — 6.7; 6.9; -1.8; -1.8 Units on a…
Phase 2 N=820 Veterans' Pain Care Organizational Improvement Comparative Effectiveness Study
Chronic Pain
Primary: Pain Response — 58; 54 Participants
Phase 3 N=58 Open-Label Safety and Tolerability Study of Oxymorphone for Acute Postoperative Pain in Pediatric Subjects.
Postoperative Pain
Primary: Summary of Visual Analog Scales (VAS) of Pain Intensity Change From Baseline by Treatment Group With Single Dose of Oxymorphone IR Tablet and Multiple Dose of…