Phase 3 N=24 Investigate Oral Bacteria in Adult Population
Oral Bacteria
Primary: Antimicrobial Species in Plaque(Actinomyces) — 0.023; 0.3881; 0.0538 log CFU (Colony forming units) — p=0.05
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 3 N=22 Efficacy of Salivary Bacteria and Post Brushing
Salivary Bacteria Levels
Primary: CFU (Colony Forming Units) — 7.18; 6.94 number of colony forming units — p=0.05
Phase 2 N=108 Effects of Probiotics on Oral Health
Periodontal Health · Dental Plaque Accumulation
Primary: Gingival Health — 0.46; 0.18 units on a scale — p=0.015
Phase 3 N=48 Reducing Bacteria That Cause Tooth Decay
Caries, Dental · Cariostatic Agents
Primary: Microbial Levels — 11; 7; 15; 15 Participants — p=0.35
Phase 4 N=128 Clinical Investigation to Examine Toothpaste Effect on Oral Bacteria
Oral Bacteria Levels in the Mouth
Primary: Anaerobic Bacteria — 8.40; 8.42; 8.43 colony forming units — p=>0.05
N/A N=15 Effect of Two Toothpastes on Bacteria in Saliva
Oral Health
Primary: Change From Baseline in Area Under the Curve Between 0 and 2 Hours (AUC [0-2] Hours) for Total Viable Counts (TVCs) of Bacteria in Saliva Using Traditional Plating…
Phase 3 N=6 Effect on Bacterial Glycolytic Acid Formation on Plaque
Dental Plaque
Primary: ph of Dental Plaque After Sucrose Challenge — 4.88; 5.04; 4.98 ph of dental plaque — p=0.05
N/A N=55 A Study to Evaluate the Effect of a Stannous Fluoride Toothpaste on the Oral Microbiome
Oral Health
Primary: Alpha Diversity at Baseline (Day 1) — 3.7; 3.5 Shannon index
Phase 2 N=75 Effect of Xylitol on Oral Microbiota in Children
Bacterial Infections
Primary: MS Counts of Stimulated Saliva — 4.86; 4.40; 4.29; 3.78 MS counts log CFU/ml
Phase 2 N=45 Inulin and S. Salivarius Reduce Halitosis
Halitosis · Tongue Diseases
Primary: Halitosis Measured by Organoleptic Test — 3.2; 3.2; 2.9; 1.4 score on a scale
N/A N=32 Induced Gingivitis & Intra-oral Imaging
Plaque Induced Gingivitis
Primary: Change From Baseline Gingivitis at Day 14 as Measured by Non-invasive Microimaging and Gingival Index. — 0.6; 0.15 units on a scale
Phase 2 N=175 Effect of Improved Oral Hygiene to Prevent Pneumonia in Hospitalized Patients
Pneumonia
Primary: Colonization of the Oral Cavity by Respiratory Pathogens (on Teeth/Denture/Buccal Mucosa) as Determined by Quantitative Cultures Expressed as Colony Forming Units (Cfu)…
Phase 4 N=49 Compare Anti-inflammatory Dentifrices
Gingivitis
Primary: Gingival Index (GI) — 1.04; 1.01 units on a scale — p=<0.05
Phase 2 N=44 The Effect of Chlorhexidine on the Oral and Lung Microbiota in Chronic Obstructive Pulmonary Disease
Chronic Obstructive Pulmonary Disease
Primary: Change in Sputum Bacteria Biomass — -0.24; -0.14 log10 molecules/uL/mL
Phase 4 N=155 Baseline Oral Health Study: UnCoVer the Connections to General Health
Cardiovascular Diseases · Diabetes Type 2
Primary: Impact of Treatment on Change in Oral Health Measures — 0.186; 0.190 millimeters (probing depth difference) — p=0.957
N/A N=42 Ecological Effect of Arginine Dentifrice on Oral Microbiota
Dental Caries · Oral Bacterial Infection · Microbiota
Primary: The Change of Abundance of Specific Oral Microbes After Intervention as Assessed by 16S rRNA Sequencing — 0.00756; 0.14636; 0.00629; 0.11956 percentage of bacteria
Phase 4 N=20 The Effect of Silver Diamine Fluoride (SDF) on Bacteria Involved in Root or Cervical Carious Lesions
Caries
Primary: Change in Bacterial Composition Before and One Month After SDF Application to Root or Cervical Caries Lesions — 1890087; 1959306 bacterial count
N/A N=100 Efficacy of an Antibacterial Toothpaste and Patients' Satisfaction
Caries · Gingivitis
Primary: Bacterial Count of Streptococcus Mutans (S. Mutans) — 4.261; 4.277 log CFU/ml
N/A N=96 Oral Tissue Tolerance of a Mouthrinse
Dental Health
Primary: Change in Tooth Color as Represented by ΔE at 8 Weeks Post Baseline From the CIElab Assessment — 0.909; 1.035 units on a scale — p=0.168
N/A N=414 Oral Hygiene in Assisted Living
Aging · Long-Term Care
Primary: Plaque Index Score for Long-Term Care (PI-LTC) - Baseline-Aim2 — 1.6; 1.6 score on a scale — p=0.77
N/A N=68 Comparison of Oral Hygiene & Root Resorption During Orthodontic Treatment
Orthodontic Pathological Resorption of External Root · Complication of Personal Oral Hygiene
Primary: Plaque Index — 0.5; 0.7; 0.7; 0.8 Plaque Index (PI)
Phase 3 N=60 Anticaries Effect of Xylitol,Probiotic and Chlorhexidine Mouth Rinses Among Individuals at High Risk
Cariostatic Agents · Mouthwashes
Primary: Change in Streptococcus Mutans Levels in Dental Plaque — 3.11; 0.93; 1.91; 2.23 log10CFU/g — p=0.123
Phase 2 N=246 To Evaluate Efficacy and Tolerability of Sodium Bicarbonate Toothpaste and Its Effect on Opportunistic or Resistant Organisms
Oral Hygiene
Primary: Number of Gingival Bleeding Sites at 24 Weeks — 13.24; 24.90 Number of bleeding sites — p=<0.0001
Phase 2 N=30 A Study to Evaluate the Microbiology, Safety and Tolerability of C16G2 Dental Strip Application
Dental Caries
Primary: Antimicrobial Activity of C16G2 — -0.2; -0.04; 0.005; 0.15 CFU/mL
Phase 3 N=73 Clinical Research Study Efficacy of a Prototype Oral Rinse
Dental Plaque
Primary: Gingival Index — 1.90; 1.84 Units on a scale — p=0.005
Phase 2 N=23 Effect of a Commercial Cosmetic Mouth Rinse on Plaque Re-growth
Healthy Subjects
Primary: Plaque Index of Test Mouth Rinse Versus Sterile Water After Day 4 of Treatment Administration — 3.03; 3.23 Score on a scale — p=0.0915
N/A N=746 Oral Hygiene and Maternity Outcomes Multicenter Study (OHMOM)
Gingivitis · Pregnancy
Primary: Change From Baseline in Löe-Silness Gingivitis Index — 0.141; 0.154 score on a scale
N/A N=90 A Comparative Study of Electric Toothbrushes for the Efficacy Plaque Removal and the Effect on Plaque Accumulation and Gingivitis.
Dental Plaque Induced Gingivitis · Dental Plaque
Primary: Plaque Index — 1.07; 1.19; 1.31; 1.11 units on a scale — p=0.1561
N/A N=200 A Clinical Study to Evaluate Effects of an Oral Rinse on Plaque and Gingivitis
Plaque
Primary: Plaque Index Score Per Participant at 6 Months — 2.12; 2.70; 2.23; 2.84 score on a scale — p=<0.0001
Phase 2 N=28 Evaluating Commercial Anti-Plaque Products and Oral Rinse
Dental Plaque
Primary: Plaque Index — 2.63; 2.65; 1.23 Units on a scale — p=0.05