N/A N=92 Past Pain Experience and Perception of Experimental Pain
Schizophrenia · Major Depression
Primary: Visual Analog Scale Evaluation for the Pre-fixed Pressure Test — 2.8; 2.1; 1.2 units on a scale — p=0.121
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=100 Mechanisms of Sleep Disruption Hyperalgesia
Sleep Deprivation · Pain
Primary: Spinal Sensitization as Assessed by Area of Secondary Hyperalgesia (2HA) After Two Nights of Uninterrupted Sleep and Two Nights of 8 Forced Awakenings — 1276.25…
N/A N=828 Multiple Areas of Pain (MAP)
Chronic Pain
Primary: Multi-site Pain Index — 0.52 units on a scale
N/A N=114 Behavioral Treatments for Chronic Pain
Intractable Pain
Primary: Brief Pain Inventory — 4.5; 5.1 units on a scale — p=.27
Early Phase 1 N=22 Developing Brain Stimulation as a Treatment for Chronic Pain in Opiate Dependent
Chronic Pain · Opiate Dependence · Lower Back Pain
Primary: Change in Quantitative Pain Testing Following Active TMS Compared to Baseline — 1.4; .3 Change from Baseline (degrees C) — p=.83
N/A N=38 Project Relief: Developing Brain Stimulation as a Treatment for Chronic Pain
Chronic Pain · Chronic Lower Back Pain · Back Pain
Primary: Changes in Patient Reported Pain and Discomfort — 47; 13; -30; -18 percent change from baseline
N/A N=49 Behavior During Experimentally Induced Pain
Schizophrenia · Major Depression
Primary: Indicators / Minute — 1.925; 0.23; 0.4; 0.45 indicators/minute — p=0.992
N/A N=24 Duloxetine for Treatment of Painful Temporomandibular Joint Disorder
Temporomandibular Joint Disorders
Primary: Spontaneous Pain as Measured by Visual Analog Scale at Baseline and at End of 6 Weeks. — 42.9; 51.4; 30.4; 44 units on a scale
Phase 4 N=81 Opioid Treatment for Chronic Low Back Pain and the Impact of Mood Symptoms
Chronic Low Back Pain · Degenerative Disc Disease · Depression
Primary: Percent Change in Average Daily Pain Score — 38.6; 30.0; 20.6 percent change — p=0.01
N/A N=95 Positive Affect as a Source of Resilience for Adults in Chronic Pain
Geriatric · Chronic Pain
Primary: Recruitment as Measured by Rates of Enrollment (Aim 1) — 120; 95; 22; 2 Participants
N/A N=36 Virtual Reality Guided Imagery for Chronic Pain
Complex Regional Pain Syndromes · Back Pain
Primary: Number of Participants Who Are Recruited But Not Enrolled as Documented in Participant Log — 60 Participants
N/A N=90 Internet Based Cognitive Behavioral Therapy in Pediatric Chronic Pancreatitis
Chronic Pancreatitis · Acute Recurrent Pancreatitis
Primary: Change in Adolescent Abdominal Pain Severity — 2.11; 1.74; 1.99; 1.61 scores on a scale
Phase 4 N=82 Placebo In Chronic Back Pain - Double-Blind Randomized Control Trial
Chronic Low Back Pain
Primary: Change in Pain Assessed by Visual Analogue Scale (VAS) — -0.03; -0.10; -0.21 percentage of change in pain
N/A N=151 Mind-body Treatments for Chronic Back Pain
Chronic Pain · Back Pain Lower Back Chronic · Back Pain, Low
Primary: Brief Pain Inventory-Short Form (BPI-SF) — 1.18; 2.84; 3.13 units on a scale
N/A N=294 Comprehensive vs. Assisted Management of Mood and Pain Symptoms
Pain · Depression · Anxiety
Primary: Composite Z-score of Pain-anxiety-depression Severity — -0.52; -0.65 units on a scale
Phase 4 N=94 Placebo In Chronic Back Pain (Phase 2)
Chronic Low Back Pain
Primary: Percent Change in Pain Assessed by Visual Analogue Scale (VAS) — -0.0145; -0.2082; -0.1109 percentage of pain change
N/A N=290 Literacy-Adapted Psychosocial Treatments for Chronic Pain --- "Learning About Mastering/My Pain"
Chronic Pain · Pain · Widespread Chronic Pain
Primary: Brief Pain Inventory-Intensity (BPI-Intensity) — 6.19; 5.42; 5.68; 5.95 units on a scale — p=.165
N/A N=116 Mindful Action for Pain
Chronic Pain
Primary: Brief Pain Inventory (BPI) Pain Interference Subscale Change — 6.77; 7.31; 7.38; 5.40 units on a scale
N/A N=850 Pain Program for Active Coping & Training
Chronic Non-malignant Pain
Primary: Pain Impact Assessed Using the 4-Item Version of Brief Pain Inventory-Short Form ("PEGS") — 6.485; 6.645; 5.486; 6.210 score on a scale
N/A N=525 Integrated Services for Pain: Interventions to Reduce Pain Effectively
Chronic Pain
Primary: Change From Baseline in Average Daily Opioid Dose in Morphine Milligram Equivalents (MME) at Month 12 — -11.6; -6.0 Morphine Milligram Equivalents (MME) — p=0.31
Phase 2 N=140 Comparison of Psychological and Pharmacological Treatments for Pain Due to Temporomandibular Joint Disorder (TMD)
Temporomandibular Joint Disorders
Primary: Average Pain — 4.7; 4.4; 4.5; 5.0 units on a scale — p=<.05
N/A N=69 Efficacy of Pain Neuroscience Education in Genito-Pelvic Pain/Penetration Disorder. A Randomized Controlled Trial.
Pain · Dysfunction Sexual
Primary: Visual Analogue Scale — 5.3; 5.8; 5.1; 3.8 score on a scale
N/A N=105 NEPAL (Neuromodulatory Examination of Pain and Mobility Across the Lifespan)
Musculoskeletal Pain · Pain, Chronic
Primary: Short Physical Performance Battery (SPPB) — 10.95; 10.82; 11.75 score on a scale — p=0.0561
N/A N=91 Living in Full Even With Pain Study
Musculoskeletal Pain · Chronic Pain
Primary: Change in Morphine Milligram Equivalent (MME) Average Daily Dose — 8; 4; 5; 5 participants — p=>.05
N/A N=163 Treating Chronic Pain in Buprenorphine Patients in Primary Care Settings
Opioid-Related Disorders
Primary: Pain Interference Based on the Brief Pain Inventory — 5.01; 4.67 units on a scale
N/A N=254 Neuromodulatory Treatments for Pain Management in TBI
Chronic Pain · Traumatic Brain Injury · Posttraumatic Stress Disorder
Primary: Change in Self-reported Pain Intensity — -1.02; -0.78; -1.03 score on a scale — p=0.2852
N/A N=20 VANISH for Chronic Low Back Pain
Chronic Low-back Pain
Primary: Assessment of Opioid Use Via Subject Report — 47.5; 21.75 morphine milligram equivalent
N/A N=21 Treatment of Insomnia Secondary to Chronic Pain
Insomnia · Pain
Primary: Insomnia Severity — 6.0; 12.8; 4.4; 13.0 units on a scale — p=0.010
Phase 4 N=86 Comparing Effectiveness of Duloxetine and Desipramine in Patients With Chronic Pain: A Pragmatic Trial Using Point of Care Randomization
Chronic Pain
Primary: Pain Intensity — 11; 29 Participants
N/A N=38 The Neurobiology of Expectancy and Pain Perception
Pain
Primary: Subjective Response to Pain (0-20 Visual Analogue Scale) — 10.7; 11; 11.2; 8.1 units on a scale